{
  "url": "https://dantelabs.com/traits/tracheal-stenosis",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "tracheal-stenosis",
    "id": "HP:0002777",
    "name": "Narrowing of windpipe",
    "label": "Tracheal stenosis",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-tracheal-morphology",
        "name": "Abnormal tracheal morphology",
        "url": "https://dantelabs.com/traits/abnormal-tracheal-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "laryngotracheal-stenosis",
        "name": "Laryngotracheal stenosis",
        "genes": 5,
        "url": "https://dantelabs.com/traits/laryngotracheal-stenosis"
      },
      {
        "slug": "tracheal-atresia",
        "name": "Tracheal atresia",
        "genes": 4,
        "url": "https://dantelabs.com/traits/tracheal-atresia"
      }
    ],
    "genes": [
      {
        "slug": "bub1",
        "symbol": "BUB1",
        "hgnc": "HGNC:1148",
        "name": "BUB1 mitotic checkpoint serine/threonine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bub1"
      },
      {
        "slug": "hoxd13",
        "symbol": "HOXD13",
        "hgnc": "HGNC:5136",
        "name": "homeobox D13",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxd13"
      },
      {
        "slug": "rmrp",
        "symbol": "RMRP",
        "hgnc": "HGNC:10031",
        "name": "RNA component of mitochondrial RNA processing endoribonuclease",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rmrp"
      },
      {
        "slug": "dhcr7",
        "symbol": "DHCR7",
        "hgnc": "HGNC:2860",
        "name": "7-dehydrocholesterol reductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhcr7"
      },
      {
        "slug": "hyls1",
        "symbol": "HYLS1",
        "hgnc": "HGNC:26558",
        "name": "HYLS1 centriolar and ciliogenesis associated",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hyls1"
      },
      {
        "slug": "rspo2",
        "symbol": "RSPO2",
        "hgnc": "HGNC:28583",
        "name": "R-spondin 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rspo2"
      },
      {
        "slug": "tbx4",
        "symbol": "TBX4",
        "hgnc": "HGNC:11603",
        "name": "T-box transcription factor 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx4"
      },
      {
        "slug": "wnt3",
        "symbol": "WNT3",
        "hgnc": "HGNC:12782",
        "name": "Wnt family member 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt3"
      },
      {
        "slug": "adamtsl2",
        "symbol": "ADAMTSL2",
        "hgnc": "HGNC:14631",
        "name": "ADAMTS like 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/adamtsl2"
      },
      {
        "slug": "arsl",
        "symbol": "ARSL",
        "hgnc": "HGNC:719",
        "name": "arylsulfatase L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arsl"
      },
      {
        "slug": "ddrgk1",
        "symbol": "DDRGK1",
        "hgnc": "HGNC:16110",
        "name": "DDRGK domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddrgk1"
      },
      {
        "slug": "fbn1",
        "symbol": "FBN1",
        "hgnc": "HGNC:3603",
        "name": "fibrillin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbn1"
      },
      {
        "slug": "foxi1",
        "symbol": "FOXI1",
        "hgnc": "HGNC:3815",
        "name": "forkhead box I1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxi1"
      },
      {
        "slug": "fras1",
        "symbol": "FRAS1",
        "hgnc": "HGNC:19185",
        "name": "Fraser extracellular matrix complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fras1"
      },
      {
        "slug": "frem2",
        "symbol": "FREM2",
        "hgnc": "HGNC:25396",
        "name": "FRAS1 related extracellular matrix 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frem2"
      },
      {
        "slug": "grip1",
        "symbol": "GRIP1",
        "hgnc": "HGNC:18708",
        "name": "glutamate receptor interacting protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grip1"
      },
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "ltbp3",
        "symbol": "LTBP3",
        "hgnc": "HGNC:6716",
        "name": "latent transforming growth factor beta binding protein 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ltbp3"
      },
      {
        "slug": "pcnt",
        "symbol": "PCNT",
        "hgnc": "HGNC:16068",
        "name": "pericentrin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcnt"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "hgnc": "HGNC:8818",
        "name": "solute carrier family 26 member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a4"
      },
      {
        "slug": "sox9",
        "symbol": "SOX9",
        "hgnc": "HGNC:11204",
        "name": "SRY-box transcription factor 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox9"
      },
      {
        "slug": "zeb2",
        "symbol": "ZEB2",
        "hgnc": "HGNC:14881",
        "name": "zinc finger E-box binding homeobox 2",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/zeb2"
      },
      {
        "slug": "ebp",
        "symbol": "EBP",
        "hgnc": "HGNC:3133",
        "name": "EBP cholestenol delta-isomerase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebp"
      },
      {
        "slug": "flnb",
        "symbol": "FLNB",
        "hgnc": "HGNC:3755",
        "name": "filamin B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flnb"
      },
      {
        "slug": "idua",
        "symbol": "IDUA",
        "hgnc": "HGNC:5391",
        "name": "alpha-L-iduronidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idua"
      },
      {
        "slug": "map3k7",
        "symbol": "MAP3K7",
        "hgnc": "HGNC:6859",
        "name": "mitogen-activated protein kinase kinase kinase 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k7"
      }
    ]
  }
}