{
  "url": "https://dantelabs.com/traits/tonic-seizure",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "tonic-seizure",
    "id": "HP:0032792",
    "name": "Tonic seizure",
    "definition": "A tonic seizure is a type of motor seizure characterized by unilateral or bilateral limb stiffening or elevation, often with neck stiffening.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "motor-seizure",
        "name": "Motor seizure",
        "url": "https://dantelabs.com/traits/motor-seizure"
      }
    ],
    "narrower": [
      {
        "slug": "generalized-tonic-seizure",
        "name": "Generalized tonic seizure",
        "genes": 71,
        "url": "https://dantelabs.com/traits/generalized-tonic-seizure"
      },
      {
        "slug": "focal-tonic-seizure",
        "name": "Focal tonic seizure",
        "genes": 40,
        "url": "https://dantelabs.com/traits/focal-tonic-seizure"
      }
    ],
    "genes": [
      {
        "slug": "arfgef1",
        "symbol": "ARFGEF1",
        "hgnc": "HGNC:15772",
        "name": "ARF guanine nucleotide exchange factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arfgef1"
      },
      {
        "slug": "arhgef9",
        "symbol": "ARHGEF9",
        "hgnc": "HGNC:14561",
        "name": "Cdc42 guanine nucleotide exchange factor 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgef9"
      },
      {
        "slug": "arid2",
        "symbol": "ARID2",
        "hgnc": "HGNC:18037",
        "name": "AT-rich interaction domain 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arid2"
      },
      {
        "slug": "arx",
        "symbol": "ARX",
        "hgnc": "HGNC:18060",
        "name": "aristaless related homeobox",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arx"
      },
      {
        "slug": "atp6v0c",
        "symbol": "ATP6V0C",
        "hgnc": "HGNC:855",
        "name": "ATPase H+ transporting V0 subunit c",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v0c"
      },
      {
        "slug": "baiap2",
        "symbol": "BAIAP2",
        "hgnc": "HGNC:947",
        "name": "BAR/IMD domain containing adaptor protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/baiap2"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "hgnc": "HGNC:1390",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1c"
      },
      {
        "slug": "clcn3",
        "symbol": "CLCN3",
        "hgnc": "HGNC:2021",
        "name": "Cl-/H+ antiporter 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clcn3"
      },
      {
        "slug": "cnksr2",
        "symbol": "CNKSR2",
        "hgnc": "HGNC:19701",
        "name": "connector enhancer of kinase suppressor of Ras 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cnksr2"
      },
      {
        "slug": "fgf12",
        "symbol": "FGF12",
        "hgnc": "HGNC:3668",
        "name": "fibroblast growth factor 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf12"
      },
      {
        "slug": "gabra5",
        "symbol": "GABRA5",
        "hgnc": "HGNC:4079",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra5"
      },
      {
        "slug": "gtf3c3",
        "symbol": "GTF3C3",
        "hgnc": "HGNC:4666",
        "name": "general transcription factor IIIC subunit 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf3c3"
      },
      {
        "slug": "hnrnpu",
        "symbol": "HNRNPU",
        "hgnc": "HGNC:5048",
        "name": "heterogeneous nuclear ribonucleoprotein U",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnrnpu"
      },
      {
        "slug": "inpp4a",
        "symbol": "INPP4A",
        "hgnc": "HGNC:6074",
        "name": "inositol polyphosphate-4-phosphatase type I A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp4a"
      },
      {
        "slug": "kcnc2",
        "symbol": "KCNC2",
        "hgnc": "HGNC:6234",
        "name": "potassium voltage-gated channel subfamily C member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnc2"
      },
      {
        "slug": "kcnt2",
        "symbol": "KCNT2",
        "hgnc": "HGNC:18866",
        "name": "potassium sodium-activated channel subfamily T member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnt2"
      },
      {
        "slug": "klhl20",
        "symbol": "KLHL20",
        "hgnc": "HGNC:25056",
        "name": "kelch like family member 20",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl20"
      },
      {
        "slug": "mccc1",
        "symbol": "MCCC1",
        "hgnc": "HGNC:6936",
        "name": "methylcrotonyl-CoA carboxylase subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mccc1"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "napb",
        "symbol": "NAPB",
        "hgnc": "HGNC:15751",
        "name": "NSF attachment protein beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/napb"
      },
      {
        "slug": "nexmif",
        "symbol": "NEXMIF",
        "hgnc": "HGNC:29433",
        "name": "neurite extension and migration factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nexmif"
      },
      {
        "slug": "phactr1",
        "symbol": "PHACTR1",
        "hgnc": "HGNC:20990",
        "name": "phosphatase and actin regulator 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phactr1"
      },
      {
        "slug": "pigw",
        "symbol": "PIGW",
        "hgnc": "HGNC:23213",
        "name": "phosphatidylinositol glycan anchor biosynthesis class W",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigw"
      },
      {
        "slug": "plcb1",
        "symbol": "PLCB1",
        "hgnc": "HGNC:15917",
        "name": "phospholipase C beta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plcb1"
      },
      {
        "slug": "plpbp",
        "symbol": "PLPBP",
        "hgnc": "HGNC:9457",
        "name": "pyridoxal phosphate binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plpbp"
      },
      {
        "slug": "pomk",
        "symbol": "POMK",
        "hgnc": "HGNC:26267",
        "name": "protein O-mannose kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomk"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "ptpn23",
        "symbol": "PTPN23",
        "hgnc": "HGNC:14406",
        "name": "protein tyrosine phosphatase non-receptor type 23",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn23"
      },
      {
        "slug": "scn2a",
        "symbol": "SCN2A",
        "hgnc": "HGNC:10588",
        "name": "sodium voltage-gated channel alpha subunit 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/scn2a"
      },
      {
        "slug": "slc25a12",
        "symbol": "SLC25A12",
        "hgnc": "HGNC:10982",
        "name": "solute carrier family 25 member 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a12"
      },
      {
        "slug": "sv2a",
        "symbol": "SV2A",
        "hgnc": "HGNC:20566",
        "name": "synaptic vesicle glycoprotein 2A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sv2a"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "tsen2",
        "symbol": "TSEN2",
        "hgnc": "HGNC:28422",
        "name": "tRNA splicing endonuclease subunit 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsen2"
      },
      {
        "slug": "uggt1",
        "symbol": "UGGT1",
        "hgnc": "HGNC:15663",
        "name": "UDP-glucose glycoprotein glucosyltransferase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uggt1"
      },
      {
        "slug": "unc13a",
        "symbol": "UNC13A",
        "hgnc": "HGNC:23150",
        "name": "unc-13 homolog A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13a"
      },
      {
        "slug": "vps53",
        "symbol": "VPS53",
        "hgnc": "HGNC:25608",
        "name": "VPS53 subunit of GARP complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps53"
      },
      {
        "slug": "alg13",
        "symbol": "ALG13",
        "hgnc": "HGNC:30881",
        "name": "ALG13 UDP-N-acetylglucosaminyltransferase subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg13"
      },
      {
        "slug": "atp6v0a1",
        "symbol": "ATP6V0A1",
        "hgnc": "HGNC:865",
        "name": "ATPase H+ transporting V0 subunit a1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v0a1"
      },
      {
        "slug": "atp6v1a",
        "symbol": "ATP6V1A",
        "hgnc": "HGNC:851",
        "name": "ATPase H+ transporting V1 subunit A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1a"
      },
      {
        "slug": "cacna1b",
        "symbol": "CACNA1B",
        "hgnc": "HGNC:1389",
        "name": "calcium voltage-gated channel subunit alpha1 B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1b"
      },
      {
        "slug": "cenpe",
        "symbol": "CENPE",
        "hgnc": "HGNC:1856",
        "name": "centromere protein E",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cenpe"
      },
      {
        "slug": "chaserr",
        "symbol": "CHASERR",
        "hgnc": "HGNC:48626",
        "name": "CHD2 adjacent suppressive regulatory RNA",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chaserr"
      },
      {
        "slug": "chd2",
        "symbol": "CHD2",
        "hgnc": "HGNC:1917",
        "name": "chromodomain helicase DNA binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd2"
      },
      {
        "slug": "cog3",
        "symbol": "COG3",
        "hgnc": "HGNC:18619",
        "name": "component of oligomeric golgi complex 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cog3"
      },
      {
        "slug": "cul3",
        "symbol": "CUL3",
        "hgnc": "HGNC:2553",
        "name": "cullin 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cul3"
      },
      {
        "slug": "cux2",
        "symbol": "CUX2",
        "hgnc": "HGNC:19347",
        "name": "cut like homeobox 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cux2"
      },
      {
        "slug": "d2hgdh",
        "symbol": "D2HGDH",
        "hgnc": "HGNC:28358",
        "name": "D-2-hydroxyglutarate dehydrogenase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/d2hgdh"
      },
      {
        "slug": "dennd5a",
        "symbol": "DENND5A",
        "hgnc": "HGNC:19344",
        "name": "DENN domain containing 5A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dennd5a"
      },
      {
        "slug": "dmxl2",
        "symbol": "DMXL2",
        "hgnc": "HGNC:2938",
        "name": "Dmx like 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmxl2"
      },
      {
        "slug": "dnm1",
        "symbol": "DNM1",
        "hgnc": "HGNC:2972",
        "name": "dynamin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnm1"
      },
      {
        "slug": "dock7",
        "symbol": "DOCK7",
        "hgnc": "HGNC:19190",
        "name": "dedicator of cytokinesis 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock7"
      },
      {
        "slug": "elfn1",
        "symbol": "ELFN1",
        "hgnc": "HGNC:33154",
        "name": "extracellular leucine rich repeat and fibronectin type III domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elfn1"
      },
      {
        "slug": "fbxo28",
        "symbol": "FBXO28",
        "hgnc": "HGNC:29046",
        "name": "F-box protein 28",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo28"
      },
      {
        "slug": "fzr1",
        "symbol": "FZR1",
        "hgnc": "HGNC:24824",
        "name": "fizzy and cell division cycle 20 related 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fzr1"
      },
      {
        "slug": "gabbr2",
        "symbol": "GABBR2",
        "hgnc": "HGNC:4507",
        "name": "gamma-aminobutyric acid type B receptor subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabbr2"
      },
      {
        "slug": "gabra1",
        "symbol": "GABRA1",
        "hgnc": "HGNC:4075",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra1"
      },
      {
        "slug": "hid1",
        "symbol": "HID1",
        "hgnc": "HGNC:15736",
        "name": "HID1 domain containing",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hid1"
      },
      {
        "slug": "hivep2",
        "symbol": "HIVEP2",
        "hgnc": "HGNC:4921",
        "name": "HIVEP zinc finger 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hivep2"
      },
      {
        "slug": "kcnq2",
        "symbol": "KCNQ2",
        "hgnc": "HGNC:6296",
        "name": "potassium voltage-gated channel subfamily Q member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq2"
      },
      {
        "slug": "kdm5c",
        "symbol": "KDM5C",
        "hgnc": "HGNC:11114",
        "name": "lysine demethylase 5C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm5c"
      },
      {
        "slug": "lnpk",
        "symbol": "LNPK",
        "hgnc": "HGNC:21610",
        "name": "lunapark, ER junction formation factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lnpk"
      },
      {
        "slug": "mast3",
        "symbol": "MAST3",
        "hgnc": "HGNC:19036",
        "name": "microtubule associated serine/threonine kinase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mast3"
      },
      {
        "slug": "mthfs",
        "symbol": "MTHFS",
        "hgnc": "HGNC:7437",
        "name": "methenyltetrahydrofolate synthetase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfs"
      },
      {
        "slug": "nsf",
        "symbol": "NSF",
        "hgnc": "HGNC:8016",
        "name": "N-ethylmaleimide sensitive factor, vesicle fusing ATPase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nsf"
      },
      {
        "slug": "pcdh12",
        "symbol": "PCDH12",
        "hgnc": "HGNC:8657",
        "name": "protocadherin 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcdh12"
      },
      {
        "slug": "ppp3ca",
        "symbol": "PPP3CA",
        "hgnc": "HGNC:9314",
        "name": "protein phosphatase 3 catalytic subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp3ca"
      },
      {
        "slug": "rnu2-2",
        "symbol": "RNU2-2",
        "hgnc": "HGNC:10152",
        "name": "RNA, U2 small nuclear 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu2-2"
      },
      {
        "slug": "rusc2",
        "symbol": "RUSC2",
        "hgnc": "HGNC:23625",
        "name": "RUN and SH3 domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rusc2"
      },
      {
        "slug": "scn1a",
        "symbol": "SCN1A",
        "hgnc": "HGNC:10585",
        "name": "sodium voltage-gated channel alpha subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1a"
      },
      {
        "slug": "sqor",
        "symbol": "SQOR",
        "hgnc": "HGNC:20390",
        "name": "sulfide quinone oxidoreductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sqor"
      },
      {
        "slug": "synj1",
        "symbol": "SYNJ1",
        "hgnc": "HGNC:11503",
        "name": "synaptojanin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/synj1"
      },
      {
        "slug": "szt2",
        "symbol": "SZT2",
        "hgnc": "HGNC:29040",
        "name": "SZT2 subunit of KICSTOR complex",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/szt2"
      },
      {
        "slug": "adnp",
        "symbol": "ADNP",
        "hgnc": "HGNC:15766",
        "name": "activity dependent neuroprotector homeobox",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adnp"
      },
      {
        "slug": "atp1a3",
        "symbol": "ATP1A3",
        "hgnc": "HGNC:801",
        "name": "ATPase Na+/K+ transporting subunit alpha 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp1a3"
      },
      {
        "slug": "cacna1a",
        "symbol": "CACNA1A",
        "hgnc": "HGNC:1388",
        "name": "calcium voltage-gated channel subunit alpha1 A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1a"
      },
      {
        "slug": "cep85l",
        "symbol": "CEP85L",
        "hgnc": "HGNC:21638",
        "name": "centrosomal protein 85L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep85l"
      },
      {
        "slug": "cntnap2",
        "symbol": "CNTNAP2",
        "hgnc": "HGNC:13830",
        "name": "contactin associated protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cntnap2"
      },
      {
        "slug": "gabrg2",
        "symbol": "GABRG2",
        "hgnc": "HGNC:4087",
        "name": "gamma-aminobutyric acid type A receptor subunit gamma2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabrg2"
      },
      {
        "slug": "glul",
        "symbol": "GLUL",
        "hgnc": "HGNC:4341",
        "name": "glutamate-ammonia ligase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glul"
      },
      {
        "slug": "gnb1",
        "symbol": "GNB1",
        "hgnc": "HGNC:4396",
        "name": "G protein subunit beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnb1"
      },
      {
        "slug": "grik2",
        "symbol": "GRIK2",
        "hgnc": "HGNC:4580",
        "name": "glutamate ionotropic receptor kainate type subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grik2"
      },
      {
        "slug": "kcnq5",
        "symbol": "KCNQ5",
        "hgnc": "HGNC:6299",
        "name": "potassium voltage-gated channel subfamily Q member 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq5"
      },
      {
        "slug": "mdga2",
        "symbol": "MDGA2",
        "hgnc": "HGNC:19835",
        "name": "MAM domain containing glycosylphosphatidylinositol anchor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdga2"
      },
      {
        "slug": "nacc1",
        "symbol": "NACC1",
        "hgnc": "HGNC:20967",
        "name": "nucleus accumbens associated 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nacc1"
      },
      {
        "slug": "pacs2",
        "symbol": "PACS2",
        "hgnc": "HGNC:23794",
        "name": "phosphofurin acidic cluster sorting protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pacs2"
      },
      {
        "slug": "pi4k2a",
        "symbol": "PI4K2A",
        "hgnc": "HGNC:30031",
        "name": "phosphatidylinositol 4-kinase type 2 alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pi4k2a"
      },
      {
        "slug": "ppfibp1",
        "symbol": "PPFIBP1",
        "hgnc": "HGNC:9249",
        "name": "PPFIB scaffold protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppfibp1"
      },
      {
        "slug": "scn8a",
        "symbol": "SCN8A",
        "hgnc": "HGNC:10596",
        "name": "sodium voltage-gated channel alpha subunit 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn8a"
      },
      {
        "slug": "slc38a3",
        "symbol": "SLC38A3",
        "hgnc": "HGNC:18044",
        "name": "solute carrier family 38 member 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc38a3"
      },
      {
        "slug": "spout1",
        "symbol": "SPOUT1",
        "hgnc": "HGNC:26933",
        "name": "SPOUT domain containing methyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spout1"
      },
      {
        "slug": "st3gal3",
        "symbol": "ST3GAL3",
        "hgnc": "HGNC:10866",
        "name": "ST3 beta-galactoside alpha-2,3-sialyltransferase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/st3gal3"
      },
      {
        "slug": "stx1b",
        "symbol": "STX1B",
        "hgnc": "HGNC:18539",
        "name": "syntaxin 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx1b"
      },
      {
        "slug": "tmem147",
        "symbol": "TMEM147",
        "hgnc": "HGNC:30414",
        "name": "transmembrane protein 147",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem147"
      },
      {
        "slug": "trim8",
        "symbol": "TRIM8",
        "hgnc": "HGNC:15579",
        "name": "tripartite motif containing 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim8"
      },
      {
        "slug": "ufsp2",
        "symbol": "UFSP2",
        "hgnc": "HGNC:25640",
        "name": "UFM1 specific peptidase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ufsp2"
      },
      {
        "slug": "gabra3",
        "symbol": "GABRA3",
        "hgnc": "HGNC:4077",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra3"
      },
      {
        "slug": "gria2",
        "symbol": "GRIA2",
        "hgnc": "HGNC:4572",
        "name": "glutamate ionotropic receptor AMPA type subunit 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gria2"
      },
      {
        "slug": "ubr5",
        "symbol": "UBR5",
        "hgnc": "HGNC:16806",
        "name": "ubiquitin protein ligase E3 component n-recognin 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubr5"
      }
    ]
  }
}