{
  "url": "https://dantelabs.com/traits/third-degree-atrioventricular-block",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "third-degree-atrioventricular-block",
    "id": "HP:0001709",
    "name": "Complete heart block",
    "label": "Third degree atrioventricular block",
    "definition": "Third-degree atrioventricular (AV) block (also referred to as complete heart block) is the complete dissociation of the atria and the ventricles. Third-degree AV block exists when more P waves than QRS complexes exist and no relationship (no conduction) exists between them.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "atrioventricular-block",
        "name": "Interruption of electrical communication between upper and lower chambers of heart",
        "url": "https://dantelabs.com/traits/atrioventricular-block"
      }
    ],
    "narrower": [
      {
        "slug": "complete-heart-block-with-broad-qrs-complexes",
        "name": "Complete heart block with broad QRS complexes",
        "genes": 1,
        "url": "https://dantelabs.com/traits/complete-heart-block-with-broad-qrs-complexes"
      }
    ],
    "genes": [
      {
        "slug": "emd",
        "symbol": "EMD",
        "hgnc": "HGNC:3331",
        "name": "emerin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emd"
      },
      {
        "slug": "grin1",
        "symbol": "GRIN1",
        "hgnc": "HGNC:4584",
        "name": "glutamate ionotropic receptor NMDA type subunit 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grin1"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "mt-atp8",
        "symbol": "MT-ATP8",
        "hgnc": "HGNC:7415",
        "name": "mitochondrially encoded ATP synthase membrane subunit 8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-atp8"
      },
      {
        "slug": "mt-tl1",
        "symbol": "MT-TL1",
        "hgnc": "HGNC:7490",
        "name": "mitochondrially encoded tRNA-Leu (UUA/G) 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tl1"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "def6",
        "symbol": "DEF6",
        "hgnc": "HGNC:2760",
        "name": "DEF6 guanine nucleotide exchange factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/def6"
      },
      {
        "slug": "prkg2",
        "symbol": "PRKG2",
        "hgnc": "HGNC:9416",
        "name": "protein kinase cGMP-dependent 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkg2"
      },
      {
        "slug": "des",
        "symbol": "DES",
        "hgnc": "HGNC:2770",
        "name": "desmin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/des"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "myl4",
        "symbol": "MYL4",
        "hgnc": "HGNC:7585",
        "name": "myosin light chain 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myl4"
      },
      {
        "slug": "ptpn11",
        "symbol": "PTPN11",
        "hgnc": "HGNC:9644",
        "name": "protein tyrosine phosphatase non-receptor type 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn11"
      }
    ]
  }
}