{
  "url": "https://dantelabs.com/traits/supraventricular-arrhythmia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "supraventricular-arrhythmia",
    "id": "HP:0005115",
    "name": "Supraventricular arrhythmia",
    "definition": "A type of arrhythmia that originates above the ventricles, whereby the electrical impulse propagates down the normal His Purkinje system similar to normal sinus rhythm.",
    "synonyms": [
      "Supraventricular arrhythmias"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "arrhythmia",
        "name": "Abnormal heart rate",
        "url": "https://dantelabs.com/traits/arrhythmia"
      }
    ],
    "narrower": [
      {
        "slug": "supraventricular-tachycardia",
        "name": "Supraventricular tachycardia",
        "genes": 43,
        "url": "https://dantelabs.com/traits/supraventricular-tachycardia"
      },
      {
        "slug": "premature-atrial-contractions",
        "name": "Premature atrial contractions",
        "genes": 9,
        "url": "https://dantelabs.com/traits/premature-atrial-contractions"
      },
      {
        "slug": "atrial-standstill",
        "name": "Atrial standstill",
        "genes": 7,
        "url": "https://dantelabs.com/traits/atrial-standstill"
      },
      {
        "slug": "atrial-arrhythmia",
        "name": "Atrial arrhythmia",
        "genes": 6,
        "url": "https://dantelabs.com/traits/atrial-arrhythmia"
      }
    ],
    "genes": [
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "col4a1",
        "symbol": "COL4A1",
        "hgnc": "HGNC:2202",
        "name": "collagen type IV alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a1"
      },
      {
        "slug": "des",
        "symbol": "DES",
        "hgnc": "HGNC:2770",
        "name": "desmin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/des"
      },
      {
        "slug": "actc1",
        "symbol": "ACTC1",
        "hgnc": "HGNC:143",
        "name": "actin alpha cardiac muscle 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actc1"
      },
      {
        "slug": "cdh23",
        "symbol": "CDH23",
        "hgnc": "HGNC:13733",
        "name": "cadherin related 23",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdh23"
      },
      {
        "slug": "cited2",
        "symbol": "CITED2",
        "hgnc": "HGNC:1987",
        "name": "Cbp/p300 interacting transactivator with ED-rich tail 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cited2"
      },
      {
        "slug": "ciz1",
        "symbol": "CIZ1",
        "hgnc": "HGNC:16744",
        "name": "CDKN1A interacting zinc finger protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciz1"
      },
      {
        "slug": "dnmt3b",
        "symbol": "DNMT3B",
        "hgnc": "HGNC:2979",
        "name": "DNA methyltransferase 3 beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3b"
      },
      {
        "slug": "dux4",
        "symbol": "DUX4",
        "hgnc": "HGNC:50800",
        "name": "double homeobox 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dux4"
      },
      {
        "slug": "dux4l1",
        "symbol": "DUX4L1",
        "hgnc": "HGNC:3082",
        "name": "double homeobox 4 like 1 (pseudogene)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dux4l1"
      },
      {
        "slug": "emd",
        "symbol": "EMD",
        "hgnc": "HGNC:3331",
        "name": "emerin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emd"
      },
      {
        "slug": "fhl1",
        "symbol": "FHL1",
        "hgnc": "HGNC:3702",
        "name": "four and a half LIM domains 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fhl1"
      },
      {
        "slug": "flnc",
        "symbol": "FLNC",
        "hgnc": "HGNC:3756",
        "name": "filamin C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flnc"
      },
      {
        "slug": "frg1",
        "symbol": "FRG1",
        "hgnc": "HGNC:3954",
        "name": "FSHD region gene 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frg1"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "hgnc": "HGNC:4173",
        "name": "GATA binding protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata4"
      },
      {
        "slug": "gata6",
        "symbol": "GATA6",
        "hgnc": "HGNC:4174",
        "name": "GATA binding protein 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata6"
      },
      {
        "slug": "kif20a",
        "symbol": "KIF20A",
        "hgnc": "HGNC:9787",
        "name": "kinesin family member 20A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif20a"
      },
      {
        "slug": "mt-atp6",
        "symbol": "MT-ATP6",
        "hgnc": "HGNC:7414",
        "name": "mitochondrially encoded ATP synthase membrane subunit 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-atp6"
      },
      {
        "slug": "myh6",
        "symbol": "MYH6",
        "hgnc": "HGNC:7576",
        "name": "myosin heavy chain 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh6"
      },
      {
        "slug": "mypn",
        "symbol": "MYPN",
        "hgnc": "HGNC:23246",
        "name": "myopalladin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mypn"
      },
      {
        "slug": "nkx2-5",
        "symbol": "NKX2-5",
        "hgnc": "HGNC:2488",
        "name": "NK2 homeobox 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nkx2-5"
      },
      {
        "slug": "smchd1",
        "symbol": "SMCHD1",
        "hgnc": "HGNC:29090",
        "name": "structural maintenance of chromosomes flexible hinge domain containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smchd1"
      },
      {
        "slug": "syne1",
        "symbol": "SYNE1",
        "hgnc": "HGNC:17089",
        "name": "spectrin repeat containing nuclear envelope protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syne1"
      },
      {
        "slug": "syne2",
        "symbol": "SYNE2",
        "hgnc": "HGNC:17084",
        "name": "spectrin repeat containing nuclear envelope protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syne2"
      },
      {
        "slug": "tbx20",
        "symbol": "TBX20",
        "hgnc": "HGNC:11598",
        "name": "T-box transcription factor 20",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx20"
      },
      {
        "slug": "tll1",
        "symbol": "TLL1",
        "hgnc": "HGNC:11843",
        "name": "tolloid like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tll1"
      },
      {
        "slug": "tmem43",
        "symbol": "TMEM43",
        "hgnc": "HGNC:28472",
        "name": "transmembrane protein 43",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem43"
      },
      {
        "slug": "tnni3",
        "symbol": "TNNI3",
        "hgnc": "HGNC:11947",
        "name": "troponin I3, cardiac type",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnni3"
      },
      {
        "slug": "tnnt2",
        "symbol": "TNNT2",
        "hgnc": "HGNC:11949",
        "name": "troponin T2, cardiac type",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnnt2"
      }
    ]
  }
}