{
  "url": "https://dantelabs.com/traits/squamous-cell-carcinoma",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "squamous-cell-carcinoma",
    "id": "HP:0002860",
    "name": "Squamous cell carcinoma",
    "definition": "The presence of squamous cell carcinoma of the skin.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "neoplasm-of-the-skin",
        "name": "Skin cancer",
        "url": "https://dantelabs.com/traits/neoplasm-of-the-skin"
      }
    ],
    "narrower": [
      {
        "slug": "squamous-cell-carcinoma-of-the-skin",
        "name": "Squamous cell carcinoma of the skin",
        "genes": 23,
        "url": "https://dantelabs.com/traits/squamous-cell-carcinoma-of-the-skin"
      },
      {
        "slug": "oropharyngeal-squamous-cell-carcinoma",
        "name": "Oropharyngeal squamous cell carcinoma",
        "genes": 6,
        "url": "https://dantelabs.com/traits/oropharyngeal-squamous-cell-carcinoma"
      }
    ],
    "genes": [
      {
        "slug": "gjb2",
        "symbol": "GJB2",
        "hgnc": "HGNC:4284",
        "name": "gap junction protein beta 2",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gjb2"
      },
      {
        "slug": "sash1",
        "symbol": "SASH1",
        "hgnc": "HGNC:19182",
        "name": "SAM and SH3 domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sash1"
      },
      {
        "slug": "brd4",
        "symbol": "BRD4",
        "hgnc": "HGNC:13575",
        "name": "bromodomain containing 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brd4"
      },
      {
        "slug": "cib1",
        "symbol": "CIB1",
        "hgnc": "HGNC:16920",
        "name": "calcium and integrin binding 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cib1"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "frequent",
        "diseases": 6,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "mmp1",
        "symbol": "MMP1",
        "hgnc": "HGNC:7155",
        "name": "matrix metallopeptidase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp1"
      },
      {
        "slug": "nutm1",
        "symbol": "NUTM1",
        "hgnc": "HGNC:29919",
        "name": "NUT midline carcinoma family member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nutm1"
      },
      {
        "slug": "polh",
        "symbol": "POLH",
        "hgnc": "HGNC:9181",
        "name": "DNA polymerase eta",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polh"
      },
      {
        "slug": "aars1",
        "symbol": "AARS1",
        "hgnc": "HGNC:20",
        "name": "alanyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aars1"
      },
      {
        "slug": "blm",
        "symbol": "BLM",
        "hgnc": "HGNC:1058",
        "name": "BLM RecQ like helicase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blm"
      },
      {
        "slug": "cars1",
        "symbol": "CARS1",
        "hgnc": "HGNC:1493",
        "name": "cysteinyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cars1"
      },
      {
        "slug": "ctsc",
        "symbol": "CTSC",
        "hgnc": "HGNC:2528",
        "name": "cathepsin C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsc"
      },
      {
        "slug": "dbr1",
        "symbol": "DBR1",
        "hgnc": "HGNC:15594",
        "name": "debranching RNA lariats 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dbr1"
      },
      {
        "slug": "dock8",
        "symbol": "DOCK8",
        "hgnc": "HGNC:19191",
        "name": "dedicator of cytokinesis 8",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dock8"
      },
      {
        "slug": "ercc2",
        "symbol": "ERCC2",
        "hgnc": "HGNC:3434",
        "name": "ERCC excision repair 2, TFIIH core complex helicase subunit",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ercc2"
      },
      {
        "slug": "ercc3",
        "symbol": "ERCC3",
        "hgnc": "HGNC:3435",
        "name": "ERCC excision repair 3, TFIIH core complex helicase subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc3"
      },
      {
        "slug": "ercc4",
        "symbol": "ERCC4",
        "hgnc": "HGNC:3436",
        "name": "ERCC excision repair 4, endonuclease catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc4"
      },
      {
        "slug": "fdps",
        "symbol": "FDPS",
        "hgnc": "HGNC:3631",
        "name": "farnesyl diphosphate synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdps"
      },
      {
        "slug": "fermt1",
        "symbol": "FERMT1",
        "hgnc": "HGNC:15889",
        "name": "FERM domain containing kindlin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fermt1"
      },
      {
        "slug": "gtf2e2",
        "symbol": "GTF2E2",
        "hgnc": "HGNC:4651",
        "name": "general transcription factor IIE subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2e2"
      },
      {
        "slug": "gtf2h5",
        "symbol": "GTF2H5",
        "hgnc": "HGNC:21157",
        "name": "general transcription factor IIH subunit 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtf2h5"
      },
      {
        "slug": "il7",
        "symbol": "IL7",
        "hgnc": "HGNC:6023",
        "name": "interleukin 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il7"
      },
      {
        "slug": "lama3",
        "symbol": "LAMA3",
        "hgnc": "HGNC:6483",
        "name": "laminin subunit alpha 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lama3"
      },
      {
        "slug": "lamb3",
        "symbol": "LAMB3",
        "hgnc": "HGNC:6490",
        "name": "laminin subunit beta 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb3"
      },
      {
        "slug": "lamc2",
        "symbol": "LAMC2",
        "hgnc": "HGNC:6493",
        "name": "laminin subunit gamma 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamc2"
      },
      {
        "slug": "mplkip",
        "symbol": "MPLKIP",
        "hgnc": "HGNC:16002",
        "name": "M-phase specific PLK1 interacting protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mplkip"
      },
      {
        "slug": "mvd",
        "symbol": "MVD",
        "hgnc": "HGNC:7529",
        "name": "mevalonate diphosphate decarboxylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mvd"
      },
      {
        "slug": "mvk",
        "symbol": "MVK",
        "hgnc": "HGNC:7530",
        "name": "mevalonate kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mvk"
      },
      {
        "slug": "nthl1",
        "symbol": "NTHL1",
        "hgnc": "HGNC:8028",
        "name": "nth like DNA glycosylase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nthl1"
      },
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/recql4"
      },
      {
        "slug": "rnf113a",
        "symbol": "RNF113A",
        "hgnc": "HGNC:12974",
        "name": "ring finger protein 113A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf113a"
      },
      {
        "slug": "slc17a9",
        "symbol": "SLC17A9",
        "hgnc": "HGNC:16192",
        "name": "solute carrier family 17 member 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc17a9"
      },
      {
        "slug": "slx4",
        "symbol": "SLX4",
        "hgnc": "HGNC:23845",
        "name": "SLX4 structure-specific endonuclease subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slx4"
      },
      {
        "slug": "tars1",
        "symbol": "TARS1",
        "hgnc": "HGNC:11572",
        "name": "threonyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tars1"
      },
      {
        "slug": "tmc6",
        "symbol": "TMC6",
        "hgnc": "HGNC:18021",
        "name": "transmembrane channel like 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmc6"
      },
      {
        "slug": "tmc8",
        "symbol": "TMC8",
        "hgnc": "HGNC:20474",
        "name": "transmembrane channel like 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmc8"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "hgnc": "HGNC:13829",
        "name": "Wnt family member 10A",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wnt10a"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      },
      {
        "slug": "aagab",
        "symbol": "AAGAB",
        "hgnc": "HGNC:25662",
        "name": "alpha and gamma adaptin binding protein",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aagab"
      },
      {
        "slug": "anapc1",
        "symbol": "ANAPC1",
        "hgnc": "HGNC:19988",
        "name": "anaphase promoting complex subunit 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/anapc1"
      },
      {
        "slug": "col14a1",
        "symbol": "COL14A1",
        "hgnc": "HGNC:2191",
        "name": "collagen type XIV alpha 1 chain",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col14a1"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "gjb6",
        "symbol": "GJB6",
        "hgnc": "HGNC:4288",
        "name": "gap junction protein beta 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gjb6"
      },
      {
        "slug": "uros",
        "symbol": "UROS",
        "hgnc": "HGNC:12592",
        "name": "uroporphyrinogen III synthase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uros"
      },
      {
        "slug": "cdkn2a",
        "symbol": "CDKN2A",
        "hgnc": "HGNC:1787",
        "name": "cyclin dependent kinase inhibitor 2A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2a"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "dkc1",
        "symbol": "DKC1",
        "hgnc": "HGNC:2890",
        "name": "dyskerin pseudouridine synthase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dkc1"
      },
      {
        "slug": "ing1",
        "symbol": "ING1",
        "hgnc": "HGNC:6062",
        "name": "inhibitor of growth family member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ing1"
      },
      {
        "slug": "nlrp1",
        "symbol": "NLRP1",
        "hgnc": "HGNC:14374",
        "name": "NLR family pyrin domain containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nlrp1"
      },
      {
        "slug": "psenen",
        "symbol": "PSENEN",
        "hgnc": "HGNC:30100",
        "name": "presenilin enhancer, gamma-secretase subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psenen"
      },
      {
        "slug": "tnfrsf10b",
        "symbol": "TNFRSF10B",
        "hgnc": "HGNC:11905",
        "name": "TNF receptor superfamily member 10b",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf10b"
      }
    ]
  }
}