{
  "url": "https://dantelabs.com/traits/severe-lactic-acidosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "severe-lactic-acidosis",
    "id": "HP:0004900",
    "name": "Severe lactic acidosis",
    "definition": "A severe form of lactic acidemia.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "lactic-acidosis",
        "name": "Increased lactate in body",
        "url": "https://dantelabs.com/traits/lactic-acidosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cox16",
        "symbol": "COX16",
        "hgnc": "HGNC:20213",
        "name": "cytochrome c oxidase assembly factor COX16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox16"
      },
      {
        "slug": "ndufs4",
        "symbol": "NDUFS4",
        "hgnc": "HGNC:7711",
        "name": "NADH:ubiquinone oxidoreductase subunit S4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs4"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "tsfm",
        "symbol": "TSFM",
        "hgnc": "HGNC:12367",
        "name": "Ts translation elongation factor, mitochondrial",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsfm"
      },
      {
        "slug": "uqcc3",
        "symbol": "UQCC3",
        "hgnc": "HGNC:34399",
        "name": "ubiquinol-cytochrome c reductase complex assembly factor 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcc3"
      },
      {
        "slug": "bcs1l",
        "symbol": "BCS1L",
        "hgnc": "HGNC:1020",
        "name": "BCS1 ubiquinol-cytochrome c reductase complex chaperone",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcs1l"
      },
      {
        "slug": "mt-te",
        "symbol": "MT-TE",
        "hgnc": "HGNC:7479",
        "name": "mitochondrially encoded tRNA-Glu (GAA/G)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-te"
      },
      {
        "slug": "mt-tt",
        "symbol": "MT-TT",
        "hgnc": "HGNC:7499",
        "name": "mitochondrially encoded tRNA-Thr (ACN)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tt"
      },
      {
        "slug": "trmu",
        "symbol": "TRMU",
        "hgnc": "HGNC:25481",
        "name": "tRNA mitochondrial 2-thiouridylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmu"
      },
      {
        "slug": "lrpprc",
        "symbol": "LRPPRC",
        "hgnc": "HGNC:15714",
        "name": "leucine rich pentatricopeptide repeat containing",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrpprc"
      },
      {
        "slug": "ndufs2",
        "symbol": "NDUFS2",
        "hgnc": "HGNC:7708",
        "name": "NADH:ubiquinone oxidoreductase core subunit S2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs2"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "pdha1",
        "symbol": "PDHA1",
        "hgnc": "HGNC:8806",
        "name": "pyruvate dehydrogenase E1 subunit alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdha1"
      },
      {
        "slug": "slc25a26",
        "symbol": "SLC25A26",
        "hgnc": "HGNC:20661",
        "name": "solute carrier family 25 member 26",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a26"
      }
    ]
  }
}