{
  "url": "https://dantelabs.com/traits/segmental-glomerulosclerosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "segmental-glomerulosclerosis",
    "id": "HP:0033495",
    "name": "Segmental glomerulosclerosis",
    "definition": "Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration and can include hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman capsule.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "glomerular-sclerosis",
        "name": "Glomerular sclerosis",
        "url": "https://dantelabs.com/traits/glomerular-sclerosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dgke",
        "symbol": "DGKE",
        "hgnc": "HGNC:2852",
        "name": "diacylglycerol kinase epsilon",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dgke"
      }
    ]
  }
}