{
  "url": "https://dantelabs.com/traits/sclerosing-cholangitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "sclerosing-cholangitis",
    "id": "HP:0030991",
    "name": "Sclerosing cholangitis",
    "definition": "Cholangitis associated with evident ductal fibrosis that develops as a consequence of long-standing bile duct inflammatory, obstruction, or ischemic injury; it can be obliterative or nonobliterative.",
    "synonyms": [
      "Fibrous cholangitis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "cholangitis",
        "name": "Bile duct inflammation",
        "url": "https://dantelabs.com/traits/cholangitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cldn1",
        "symbol": "CLDN1",
        "hgnc": "HGNC:2032",
        "name": "claudin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn1"
      },
      {
        "slug": "dcdc2",
        "symbol": "DCDC2",
        "hgnc": "HGNC:18141",
        "name": "doublecortin domain containing 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dcdc2"
      },
      {
        "slug": "rel",
        "symbol": "REL",
        "hgnc": "HGNC:9954",
        "name": "REL proto-oncogene, NF-kB subunit",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rel"
      },
      {
        "slug": "ciita",
        "symbol": "CIITA",
        "hgnc": "HGNC:7067",
        "name": "class II major histocompatibility complex transactivator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciita"
      },
      {
        "slug": "itgav",
        "symbol": "ITGAV",
        "hgnc": "HGNC:6150",
        "name": "integrin subunit alpha V",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgav"
      },
      {
        "slug": "rfx5",
        "symbol": "RFX5",
        "hgnc": "HGNC:9986",
        "name": "regulatory factor X5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx5"
      },
      {
        "slug": "rfxank",
        "symbol": "RFXANK",
        "hgnc": "HGNC:9987",
        "name": "regulatory factor X associated ankyrin containing protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rfxank"
      },
      {
        "slug": "rfxap",
        "symbol": "RFXAP",
        "hgnc": "HGNC:9988",
        "name": "regulatory factor X associated protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfxap"
      },
      {
        "slug": "cd40lg",
        "symbol": "CD40LG",
        "hgnc": "HGNC:11935",
        "name": "CD40 ligand",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd40lg"
      },
      {
        "slug": "dock8",
        "symbol": "DOCK8",
        "hgnc": "HGNC:19191",
        "name": "dedicator of cytokinesis 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock8"
      },
      {
        "slug": "kif12",
        "symbol": "KIF12",
        "hgnc": "HGNC:21495",
        "name": "kinesin family member 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif12"
      },
      {
        "slug": "abcb4",
        "symbol": "ABCB4",
        "hgnc": "HGNC:45",
        "name": "ATP binding cassette subfamily B member 4",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb4"
      },
      {
        "slug": "map2k1",
        "symbol": "MAP2K1",
        "hgnc": "HGNC:6840",
        "name": "mitogen-activated protein kinase kinase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k1"
      },
      {
        "slug": "nras",
        "symbol": "NRAS",
        "hgnc": "HGNC:7989",
        "name": "NRAS proto-oncogene, GTPase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nras"
      }
    ]
  }
}