{
  "url": "https://dantelabs.com/traits/resting-tremor",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "resting-tremor",
    "id": "HP:0002322",
    "name": "Resting tremor",
    "definition": "A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.",
    "synonyms": [
      "Tremor at rest",
      "Rest tremor"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "tremor",
        "name": "Tremor",
        "url": "https://dantelabs.com/traits/tremor"
      }
    ],
    "narrower": [
      {
        "slug": "pill-rolling-tremor",
        "name": "Pill-rolling tremor",
        "genes": 8,
        "url": "https://dantelabs.com/traits/pill-rolling-tremor"
      }
    ],
    "genes": [
      {
        "slug": "atp6ap2",
        "symbol": "ATP6AP2",
        "hgnc": "HGNC:18305",
        "name": "ATPase H+ transporting accessory protein 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp6ap2"
      },
      {
        "slug": "epg5",
        "symbol": "EPG5",
        "hgnc": "HGNC:29331",
        "name": "ectopic P-granules 5 autophagy tethering factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epg5"
      },
      {
        "slug": "lrrc7",
        "symbol": "LRRC7",
        "hgnc": "HGNC:18531",
        "name": "leucine rich repeat containing 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc7"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "vps13c",
        "symbol": "VPS13C",
        "hgnc": "HGNC:23594",
        "name": "vacuolar protein sorting 13 homolog C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13c"
      },
      {
        "slug": "chchd2",
        "symbol": "CHCHD2",
        "hgnc": "HGNC:21645",
        "name": "coiled-coil-helix-coiled-coil-helix domain containing 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chchd2"
      },
      {
        "slug": "dnajc6",
        "symbol": "DNAJC6",
        "hgnc": "HGNC:15469",
        "name": "DnaJ heat shock protein family (Hsp40) member C6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc6"
      },
      {
        "slug": "podxl",
        "symbol": "PODXL",
        "hgnc": "HGNC:9171",
        "name": "podocalyxin like",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/podxl"
      },
      {
        "slug": "ptrhd1",
        "symbol": "PTRHD1",
        "hgnc": "HGNC:33782",
        "name": "peptidyl-tRNA hydrolase domain containing 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptrhd1"
      },
      {
        "slug": "rab39b",
        "symbol": "RAB39B",
        "hgnc": "HGNC:16499",
        "name": "RAB39B, member RAS oncogene family",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab39b"
      },
      {
        "slug": "synj1",
        "symbol": "SYNJ1",
        "hgnc": "HGNC:11503",
        "name": "synaptojanin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/synj1"
      },
      {
        "slug": "adcy5",
        "symbol": "ADCY5",
        "hgnc": "HGNC:236",
        "name": "adenylate cyclase 5",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/adcy5"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "dnajc13",
        "symbol": "DNAJC13",
        "hgnc": "HGNC:30343",
        "name": "DnaJ heat shock protein family (Hsp40) member C13",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc13"
      },
      {
        "slug": "eif4g1",
        "symbol": "EIF4G1",
        "hgnc": "HGNC:3296",
        "name": "eukaryotic translation initiation factor 4 gamma 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/eif4g1"
      },
      {
        "slug": "fbxo7",
        "symbol": "FBXO7",
        "hgnc": "HGNC:13586",
        "name": "F-box protein 7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo7"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "gigyf2",
        "symbol": "GIGYF2",
        "hgnc": "HGNC:11960",
        "name": "GRB10 interacting GYF protein 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gigyf2"
      },
      {
        "slug": "lrrk2",
        "symbol": "LRRK2",
        "hgnc": "HGNC:18618",
        "name": "leucine rich repeat kinase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lrrk2"
      },
      {
        "slug": "micu1",
        "symbol": "MICU1",
        "hgnc": "HGNC:1530",
        "name": "mitochondrial calcium uptake 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/micu1"
      },
      {
        "slug": "nr4a2",
        "symbol": "NR4A2",
        "hgnc": "HGNC:7981",
        "name": "nuclear receptor subfamily 4 group A member 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nr4a2"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "polg2",
        "symbol": "POLG2",
        "hgnc": "HGNC:9180",
        "name": "DNA polymerase gamma 2, accessory subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polg2"
      },
      {
        "slug": "prkn",
        "symbol": "PRKN",
        "hgnc": "HGNC:8607",
        "name": "parkin RBR E3 ubiquitin protein ligase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkn"
      },
      {
        "slug": "psap",
        "symbol": "PSAP",
        "hgnc": "HGNC:9498",
        "name": "prosaposin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psap"
      },
      {
        "slug": "ptpa",
        "symbol": "PTPA",
        "hgnc": "HGNC:9308",
        "name": "protein phosphatase 2 phosphatase activator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpa"
      },
      {
        "slug": "rab32",
        "symbol": "RAB32",
        "hgnc": "HGNC:9772",
        "name": "RAB32, member RAS oncogene family",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab32"
      },
      {
        "slug": "rab3a",
        "symbol": "RAB3A",
        "hgnc": "HGNC:9777",
        "name": "RAB3A, member RAS oncogene family",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab3a"
      },
      {
        "slug": "rrm2b",
        "symbol": "RRM2B",
        "hgnc": "HGNC:17296",
        "name": "ribonucleotide reductase regulatory TP53 inducible subunit M2B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrm2b"
      },
      {
        "slug": "slc25a4",
        "symbol": "SLC25A4",
        "hgnc": "HGNC:10990",
        "name": "solute carrier family 25 member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a4"
      },
      {
        "slug": "slc9a6",
        "symbol": "SLC9A6",
        "hgnc": "HGNC:11079",
        "name": "solute carrier family 9 member A6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc9a6"
      },
      {
        "slug": "snca",
        "symbol": "SNCA",
        "hgnc": "HGNC:11138",
        "name": "synuclein alpha",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/snca"
      },
      {
        "slug": "taf1",
        "symbol": "TAF1",
        "hgnc": "HGNC:11535",
        "name": "TATA-box binding protein associated factor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf1"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "uqcrc1",
        "symbol": "UQCRC1",
        "hgnc": "HGNC:12585",
        "name": "ubiquinol-cytochrome c reductase core protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uqcrc1"
      },
      {
        "slug": "vps35",
        "symbol": "VPS35",
        "hgnc": "HGNC:13487",
        "name": "VPS35 retromer complex component",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vps35"
      },
      {
        "slug": "aldh18a1",
        "symbol": "ALDH18A1",
        "hgnc": "HGNC:9722",
        "name": "aldehyde dehydrogenase 18 family member A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh18a1"
      },
      {
        "slug": "atp13a2",
        "symbol": "ATP13A2",
        "hgnc": "HGNC:30213",
        "name": "ATPase cation transporting 13A2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp13a2"
      },
      {
        "slug": "atp1a3",
        "symbol": "ATP1A3",
        "hgnc": "HGNC:801",
        "name": "ATPase Na+/K+ transporting subunit alpha 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp1a3"
      },
      {
        "slug": "cacna1g",
        "symbol": "CACNA1G",
        "hgnc": "HGNC:1394",
        "name": "calcium voltage-gated channel subunit alpha1 G",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1g"
      },
      {
        "slug": "cyp27a1",
        "symbol": "CYP27A1",
        "hgnc": "HGNC:2605",
        "name": "cytochrome P450 family 27 subfamily A member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp27a1"
      },
      {
        "slug": "dnmt1",
        "symbol": "DNMT1",
        "hgnc": "HGNC:2976",
        "name": "DNA methyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt1"
      },
      {
        "slug": "gch1",
        "symbol": "GCH1",
        "hgnc": "HGNC:4193",
        "name": "GTP cyclohydrolase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gch1"
      },
      {
        "slug": "kcnn2",
        "symbol": "KCNN2",
        "hgnc": "HGNC:6291",
        "name": "potassium calcium-activated channel subfamily N member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn2"
      },
      {
        "slug": "opa3",
        "symbol": "OPA3",
        "hgnc": "HGNC:8142",
        "name": "outer mitochondrial membrane lipid metabolism regulator OPA3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/opa3"
      },
      {
        "slug": "park7",
        "symbol": "PARK7",
        "hgnc": "HGNC:16369",
        "name": "Parkinsonism associated deglycase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/park7"
      },
      {
        "slug": "ttc19",
        "symbol": "TTC19",
        "hgnc": "HGNC:26006",
        "name": "tetratricopeptide repeat domain 19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc19"
      },
      {
        "slug": "vps13a",
        "symbol": "VPS13A",
        "hgnc": "HGNC:1908",
        "name": "vacuolar protein sorting 13 homolog A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps13a"
      },
      {
        "slug": "ftl",
        "symbol": "FTL",
        "hgnc": "HGNC:3999",
        "name": "ferritin light chain",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ftl"
      },
      {
        "slug": "man1b1",
        "symbol": "MAN1B1",
        "hgnc": "HGNC:6823",
        "name": "mannosidase alpha class 1B member 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/man1b1"
      },
      {
        "slug": "adh1c",
        "symbol": "ADH1C",
        "hgnc": "HGNC:251",
        "name": "alcohol dehydrogenase 1C (class I), gamma polypeptide",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adh1c"
      },
      {
        "slug": "atxn2",
        "symbol": "ATXN2",
        "hgnc": "HGNC:10555",
        "name": "ataxin 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn2"
      },
      {
        "slug": "atxn3",
        "symbol": "ATXN3",
        "hgnc": "HGNC:7106",
        "name": "ataxin 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn3"
      },
      {
        "slug": "atxn8os",
        "symbol": "ATXN8OS",
        "hgnc": "HGNC:10561",
        "name": "ATXN8 opposite strand lncRNA",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn8os"
      },
      {
        "slug": "fmr1",
        "symbol": "FMR1",
        "hgnc": "HGNC:3775",
        "name": "fragile X messenger ribonucleoprotein 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fmr1"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "mt-tt",
        "symbol": "MT-TT",
        "hgnc": "HGNC:7499",
        "name": "mitochondrially encoded tRNA-Thr (ACN)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tt"
      },
      {
        "slug": "pink1",
        "symbol": "PINK1",
        "hgnc": "HGNC:14581",
        "name": "PTEN induced kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pink1"
      },
      {
        "slug": "sncaip",
        "symbol": "SNCAIP",
        "hgnc": "HGNC:11139",
        "name": "synuclein alpha interacting protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sncaip"
      },
      {
        "slug": "tbp",
        "symbol": "TBP",
        "hgnc": "HGNC:11588",
        "name": "TATA-box binding protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbp"
      }
    ]
  }
}