{
  "url": "https://dantelabs.com/traits/reduced-sperm-motility",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "reduced-sperm-motility",
    "id": "HP:0012207",
    "name": "Reduced sperm motility",
    "definition": "An abnormal reduction in the mobility of ejaculated sperm.",
    "synonyms": [
      "Asthenospermia",
      "Asthenozoospermia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-sperm-motility",
        "name": "Abnormal sperm motility",
        "url": "https://dantelabs.com/traits/abnormal-sperm-motility"
      }
    ],
    "narrower": [
      {
        "slug": "immotile-sperm",
        "name": "Immotile sperm",
        "genes": 17,
        "url": "https://dantelabs.com/traits/immotile-sperm"
      }
    ],
    "genes": [
      {
        "slug": "ak7",
        "symbol": "AK7",
        "hgnc": "HGNC:20091",
        "name": "adenylate kinase 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ak7"
      },
      {
        "slug": "ak9",
        "symbol": "AK9",
        "hgnc": "HGNC:33814",
        "name": "adenylate kinase 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ak9"
      },
      {
        "slug": "arl2bp",
        "symbol": "ARL2BP",
        "hgnc": "HGNC:17146",
        "name": "ARF like GTPase 2 binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arl2bp"
      },
      {
        "slug": "brdt",
        "symbol": "BRDT",
        "hgnc": "HGNC:1105",
        "name": "bromodomain testis associated",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brdt"
      },
      {
        "slug": "brwd1",
        "symbol": "BRWD1",
        "hgnc": "HGNC:12760",
        "name": "bromodomain and WD repeat domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brwd1"
      },
      {
        "slug": "catip",
        "symbol": "CATIP",
        "hgnc": "HGNC:25062",
        "name": "ciliogenesis associated TTC17 interacting protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/catip"
      },
      {
        "slug": "catsper1",
        "symbol": "CATSPER1",
        "hgnc": "HGNC:17116",
        "name": "cation channel sperm associated 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/catsper1"
      },
      {
        "slug": "catsper2",
        "symbol": "CATSPER2",
        "hgnc": "HGNC:18810",
        "name": "cation channel sperm associated 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/catsper2"
      },
      {
        "slug": "ccdc146",
        "symbol": "CCDC146",
        "hgnc": "HGNC:29296",
        "name": "coiled-coil domain containing 146",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc146"
      },
      {
        "slug": "ccdc34",
        "symbol": "CCDC34",
        "hgnc": "HGNC:25079",
        "name": "coiled-coil domain containing 34",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc34"
      },
      {
        "slug": "cep112",
        "symbol": "CEP112",
        "hgnc": "HGNC:28514",
        "name": "centrosomal protein 112",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep112"
      },
      {
        "slug": "cfap251",
        "symbol": "CFAP251",
        "hgnc": "HGNC:28506",
        "name": "cilia and flagella associated protein 251",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap251"
      },
      {
        "slug": "cfap410",
        "symbol": "CFAP410",
        "hgnc": "HGNC:1260",
        "name": "cilia and flagella associated protein 410",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap410"
      },
      {
        "slug": "cfap43",
        "symbol": "CFAP43",
        "hgnc": "HGNC:26684",
        "name": "cilia and flagella associated protein 43",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap43"
      },
      {
        "slug": "cfap47",
        "symbol": "CFAP47",
        "hgnc": "HGNC:26708",
        "name": "cilia and flagella associated protein 47",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap47"
      },
      {
        "slug": "cfap54",
        "symbol": "CFAP54",
        "hgnc": "HGNC:26456",
        "name": "cilia and flagella associated protein 54",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap54"
      },
      {
        "slug": "cfap57",
        "symbol": "CFAP57",
        "hgnc": "HGNC:26485",
        "name": "cilia and flagella associated protein 57",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap57"
      },
      {
        "slug": "cfap58",
        "symbol": "CFAP58",
        "hgnc": "HGNC:26676",
        "name": "cilia and flagella associated protein 58",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap58"
      },
      {
        "slug": "cfap69",
        "symbol": "CFAP69",
        "hgnc": "HGNC:26107",
        "name": "cilia and flagella associated protein 69",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap69"
      },
      {
        "slug": "cfap91",
        "symbol": "CFAP91",
        "hgnc": "HGNC:24010",
        "name": "cilia and flagella associated protein 91",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap91"
      },
      {
        "slug": "ct55",
        "symbol": "CT55",
        "hgnc": "HGNC:26047",
        "name": "cancer/testis antigen 55",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ct55"
      },
      {
        "slug": "dnah1",
        "symbol": "DNAH1",
        "hgnc": "HGNC:2940",
        "name": "dynein axonemal heavy chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah1"
      },
      {
        "slug": "dnah10",
        "symbol": "DNAH10",
        "hgnc": "HGNC:2941",
        "name": "dynein axonemal heavy chain 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah10"
      },
      {
        "slug": "dnah12",
        "symbol": "DNAH12",
        "hgnc": "HGNC:2943",
        "name": "dynein axonemal heavy chain 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah12"
      },
      {
        "slug": "dnah17",
        "symbol": "DNAH17",
        "hgnc": "HGNC:2946",
        "name": "dynein axonemal heavy chain 17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah17"
      },
      {
        "slug": "dnah2",
        "symbol": "DNAH2",
        "hgnc": "HGNC:2948",
        "name": "dynein axonemal heavy chain 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah2"
      },
      {
        "slug": "dnah7",
        "symbol": "DNAH7",
        "hgnc": "HGNC:18661",
        "name": "dynein axonemal heavy chain 7",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah7"
      },
      {
        "slug": "dnah8",
        "symbol": "DNAH8",
        "hgnc": "HGNC:2952",
        "name": "dynein axonemal heavy chain 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah8"
      },
      {
        "slug": "dnali1",
        "symbol": "DNALI1",
        "hgnc": "HGNC:14353",
        "name": "dynein axonemal light intermediate chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnali1"
      },
      {
        "slug": "dnhd1",
        "symbol": "DNHD1",
        "hgnc": "HGNC:26532",
        "name": "dynein heavy chain domain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnhd1"
      },
      {
        "slug": "fsip2",
        "symbol": "FSIP2",
        "hgnc": "HGNC:21675",
        "name": "fibrous sheath interacting protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fsip2"
      },
      {
        "slug": "hydin",
        "symbol": "HYDIN",
        "hgnc": "HGNC:19368",
        "name": "HYDIN axonemal central pair apparatus protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hydin"
      },
      {
        "slug": "kcnu1",
        "symbol": "KCNU1",
        "hgnc": "HGNC:18867",
        "name": "potassium calcium-activated channel subfamily U member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnu1"
      },
      {
        "slug": "rsph4a",
        "symbol": "RSPH4A",
        "hgnc": "HGNC:21558",
        "name": "radial spoke head component 4A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph4a"
      },
      {
        "slug": "rsph9",
        "symbol": "RSPH9",
        "hgnc": "HGNC:21057",
        "name": "radial spoke head component 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph9"
      },
      {
        "slug": "slc26a8",
        "symbol": "SLC26A8",
        "hgnc": "HGNC:14468",
        "name": "solute carrier family 26 member 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a8"
      },
      {
        "slug": "spag17",
        "symbol": "SPAG17",
        "hgnc": "HGNC:26620",
        "name": "sperm associated antigen 17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spag17"
      },
      {
        "slug": "ssx1",
        "symbol": "SSX1",
        "hgnc": "HGNC:11335",
        "name": "SSX family member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ssx1"
      },
      {
        "slug": "stk36",
        "symbol": "STK36",
        "hgnc": "HGNC:17209",
        "name": "serine/threonine kinase 36",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk36"
      },
      {
        "slug": "strc",
        "symbol": "STRC",
        "hgnc": "HGNC:16035",
        "name": "stereocilin",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/strc"
      },
      {
        "slug": "sun5",
        "symbol": "SUN5",
        "hgnc": "HGNC:16252",
        "name": "Sad1 and UNC84 domain containing 5",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sun5"
      },
      {
        "slug": "ttc29",
        "symbol": "TTC29",
        "hgnc": "HGNC:29936",
        "name": "tetratricopeptide repeat domain 29",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc29"
      },
      {
        "slug": "cfap61",
        "symbol": "CFAP61",
        "hgnc": "HGNC:15872",
        "name": "cilia and flagella associated protein 61",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap61"
      },
      {
        "slug": "ccdc39",
        "symbol": "CCDC39",
        "hgnc": "HGNC:25244",
        "name": "coiled-coil domain 39 molecular ruler complex subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc39"
      },
      {
        "slug": "klhl10",
        "symbol": "KLHL10",
        "hgnc": "HGNC:18829",
        "name": "kelch like family member 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl10"
      },
      {
        "slug": "lrrc23",
        "symbol": "LRRC23",
        "hgnc": "HGNC:19138",
        "name": "leucine rich repeat containing 23",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrrc23"
      },
      {
        "slug": "pdha2",
        "symbol": "PDHA2",
        "hgnc": "HGNC:8807",
        "name": "pyruvate dehydrogenase E1 subunit alpha 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdha2"
      },
      {
        "slug": "pmfbp1",
        "symbol": "PMFBP1",
        "hgnc": "HGNC:17728",
        "name": "polyamine modulated factor 1 binding protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmfbp1"
      },
      {
        "slug": "septin12",
        "symbol": "SEPTIN12",
        "hgnc": "HGNC:26348",
        "name": "septin 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/septin12"
      },
      {
        "slug": "stk33",
        "symbol": "STK33",
        "hgnc": "HGNC:14568",
        "name": "serine/threonine kinase 33",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk33"
      },
      {
        "slug": "usp26",
        "symbol": "USP26",
        "hgnc": "HGNC:13485",
        "name": "ubiquitin specific peptidase 26",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/usp26"
      },
      {
        "slug": "alg5",
        "symbol": "ALG5",
        "hgnc": "HGNC:20266",
        "name": "ALG5 dolichyl-phosphate beta-glucosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg5"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "bicc1",
        "symbol": "BICC1",
        "hgnc": "HGNC:19351",
        "name": "BicC family RNA binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicc1"
      },
      {
        "slug": "ccin",
        "symbol": "CCIN",
        "hgnc": "HGNC:1568",
        "name": "calicin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccin"
      },
      {
        "slug": "dnajb11",
        "symbol": "DNAJB11",
        "hgnc": "HGNC:14889",
        "name": "DnaJ heat shock protein family (Hsp40) member B11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb11"
      },
      {
        "slug": "ganab",
        "symbol": "GANAB",
        "hgnc": "HGNC:4138",
        "name": "glucosidase II alpha subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ganab"
      },
      {
        "slug": "gba2",
        "symbol": "GBA2",
        "hgnc": "HGNC:18986",
        "name": "glucosylceramidase beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gba2"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "pkd1",
        "symbol": "PKD1",
        "hgnc": "HGNC:9008",
        "name": "polycystin 1, transient receptor potential channel interacting",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd1"
      },
      {
        "slug": "pkd2",
        "symbol": "PKD2",
        "hgnc": "HGNC:9009",
        "name": "polycystin 2, transient receptor potential cation channel",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd2"
      },
      {
        "slug": "armc2",
        "symbol": "ARMC2",
        "hgnc": "HGNC:23045",
        "name": "armadillo repeat containing 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/armc2"
      },
      {
        "slug": "cfap298",
        "symbol": "CFAP298",
        "hgnc": "HGNC:1301",
        "name": "cilia and flagella associated protein 298",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap298"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "hgnc": "HGNC:11630",
        "name": "HNF1 homeobox B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1b"
      },
      {
        "slug": "spef2",
        "symbol": "SPEF2",
        "hgnc": "HGNC:26293",
        "name": "sperm flagellar and cilia associated 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spef2"
      },
      {
        "slug": "zmynd10",
        "symbol": "ZMYND10",
        "hgnc": "HGNC:19412",
        "name": "zinc finger MYND-type containing 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmynd10"
      }
    ]
  }
}