{
  "url": "https://dantelabs.com/traits/pretibial-blistering",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "pretibial-blistering",
    "id": "HP:0012221",
    "name": "Pretibial blistering",
    "definition": "A type of blistering that affects the skin of the tibial region.",
    "synonyms": [
      "Pretibial epidermolysis bullosa"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "blistering-by-anatomical-location",
        "name": "Blistering by anatomical location",
        "url": "https://dantelabs.com/traits/blistering-by-anatomical-location"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cd151",
        "symbol": "CD151",
        "hgnc": "HGNC:1630",
        "name": "CD151 molecule (Raph blood group)",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd151"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt5"
      }
    ]
  }
}