{
  "url": "https://dantelabs.com/traits/premature-arteriosclerosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "premature-arteriosclerosis",
    "id": "HP:0005177",
    "name": "Premature hardening of arteries",
    "label": "Premature arteriosclerosis",
    "definition": "Arteriosclerosis occurring at an age that is younger than usual.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "arteriosclerosis",
        "name": "Hardened artery wall",
        "url": "https://dantelabs.com/traits/arteriosclerosis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "abcg5",
        "symbol": "ABCG5",
        "hgnc": "HGNC:13886",
        "name": "ATP binding cassette subfamily G member 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg5"
      },
      {
        "slug": "abcg8",
        "symbol": "ABCG8",
        "hgnc": "HGNC:13887",
        "name": "ATP binding cassette subfamily G member 8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcg8"
      },
      {
        "slug": "apob",
        "symbol": "APOB",
        "hgnc": "HGNC:603",
        "name": "apolipoprotein B",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apob"
      },
      {
        "slug": "ldlr",
        "symbol": "LDLR",
        "hgnc": "HGNC:6547",
        "name": "low density lipoprotein receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldlr"
      },
      {
        "slug": "ldlrap1",
        "symbol": "LDLRAP1",
        "hgnc": "HGNC:18640",
        "name": "low density lipoprotein receptor adaptor protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldlrap1"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "pcsk9",
        "symbol": "PCSK9",
        "hgnc": "HGNC:20001",
        "name": "proprotein convertase subtilisin/kexin type 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcsk9"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      }
    ]
  }
}