{
  "url": "https://dantelabs.com/traits/persistent-fever",
  "trait": {
    "bundleId": "2026.10.18-e609d43e",
    "release": "2026-09-01",
    "slug": "persistent-fever",
    "id": "HP:0033399",
    "name": "Persistent fever",
    "definition": "Fever that persists longer than expected for an acute infectious disease. No precise threshold exists, and the clinical interpretation of fever is context-dependent, but as a rule of thumb, this term refers to fever that persists longer than 2-3 weeks.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "fever",
        "name": "Fever",
        "url": "https://dantelabs.com/traits/fever"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "c1qb",
        "symbol": "C1QB",
        "hgnc": "HGNC:1242",
        "name": "complement C1q B chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1qb"
      },
      {
        "slug": "dclre1c",
        "symbol": "DCLRE1C",
        "hgnc": "HGNC:17642",
        "name": "DNA cross-link repair 1C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dclre1c"
      },
      {
        "slug": "rag1",
        "symbol": "RAG1",
        "hgnc": "HGNC:9831",
        "name": "recombination activating 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag1"
      },
      {
        "slug": "rag2",
        "symbol": "RAG2",
        "hgnc": "HGNC:9832",
        "name": "recombination activating 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rag2"
      },
      {
        "slug": "sco2",
        "symbol": "SCO2",
        "hgnc": "HGNC:10604",
        "name": "synthesis of cytochrome C oxidase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sco2"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "zap70",
        "symbol": "ZAP70",
        "hgnc": "HGNC:12858",
        "name": "zeta chain of T cell receptor associated protein kinase 70",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zap70"
      },
      {
        "slug": "znfx1",
        "symbol": "ZNFX1",
        "hgnc": "HGNC:29271",
        "name": "zinc finger NFX1-type containing 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znfx1"
      }
    ]
  }
}