{
  "url": "https://dantelabs.com/traits/peripheral-dysmyelination",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "peripheral-dysmyelination",
    "id": "HP:0003469",
    "name": "Peripheral dysmyelination",
    "definition": "Defective structure and function of myelin sheaths. Dysmyelination is distinguished from demyleination where there is destruction or damage of previously normal myelination.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-peripheral-myelination",
        "name": "Abnormal peripheral myelination",
        "url": "https://dantelabs.com/traits/abnormal-peripheral-myelination"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mpz",
        "symbol": "MPZ",
        "hgnc": "HGNC:7225",
        "name": "myelin protein zero",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpz"
      },
      {
        "slug": "ercc6",
        "symbol": "ERCC6",
        "hgnc": "HGNC:3438",
        "name": "ERCC excision repair 6, chromatin remodeling factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc6"
      },
      {
        "slug": "ercc8",
        "symbol": "ERCC8",
        "hgnc": "HGNC:3439",
        "name": "ERCC excision repair 8, CSA ubiquitin ligase complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc8"
      },
      {
        "slug": "znhit3",
        "symbol": "ZNHIT3",
        "hgnc": "HGNC:12309",
        "name": "zinc finger HIT-type containing 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znhit3"
      }
    ]
  }
}