{
  "url": "https://dantelabs.com/traits/parkinsonism",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "parkinsonism",
    "id": "HP:0001300",
    "name": "Parkinsonism",
    "definition": "Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-extrapyramidal-motor-function",
        "name": "Abnormality of extrapyramidal motor function",
        "url": "https://dantelabs.com/traits/abnormality-of-extrapyramidal-motor-function"
      }
    ],
    "narrower": [
      {
        "slug": "parkinsonism-with-favorable-response-to-dopaminergic-medication",
        "name": "Parkinsonism with favorable response to dopaminergic medication",
        "genes": 32,
        "url": "https://dantelabs.com/traits/parkinsonism-with-favorable-response-to-dopaminergic-medication"
      }
    ],
    "genes": [
      {
        "slug": "atp6ap2",
        "symbol": "ATP6AP2",
        "hgnc": "HGNC:18305",
        "name": "ATPase H+ transporting accessory protein 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp6ap2"
      },
      {
        "slug": "cln3",
        "symbol": "CLN3",
        "hgnc": "HGNC:2074",
        "name": "CLN3 lysosomal/endosomal transmembrane protein, battenin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cln3"
      },
      {
        "slug": "csf1r",
        "symbol": "CSF1R",
        "hgnc": "HGNC:2433",
        "name": "colony stimulating factor 1 receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csf1r"
      },
      {
        "slug": "cst3",
        "symbol": "CST3",
        "hgnc": "HGNC:2475",
        "name": "cystatin C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cst3"
      },
      {
        "slug": "dctn1",
        "symbol": "DCTN1",
        "hgnc": "HGNC:2711",
        "name": "dynactin subunit 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dctn1"
      },
      {
        "slug": "dnajc13",
        "symbol": "DNAJC13",
        "hgnc": "HGNC:30343",
        "name": "DnaJ heat shock protein family (Hsp40) member C13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc13"
      },
      {
        "slug": "eif4g1",
        "symbol": "EIF4G1",
        "hgnc": "HGNC:3296",
        "name": "eukaryotic translation initiation factor 4 gamma 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/eif4g1"
      },
      {
        "slug": "fastkd5",
        "symbol": "FASTKD5",
        "hgnc": "HGNC:25790",
        "name": "FASTK mitochondrial RNA regulator 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fastkd5"
      },
      {
        "slug": "fbxo7",
        "symbol": "FBXO7",
        "hgnc": "HGNC:13586",
        "name": "F-box protein 7",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fbxo7"
      },
      {
        "slug": "fmr1",
        "symbol": "FMR1",
        "hgnc": "HGNC:3775",
        "name": "fragile X messenger ribonucleoprotein 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fmr1"
      },
      {
        "slug": "gba1",
        "symbol": "GBA1",
        "hgnc": "HGNC:4177",
        "name": "glucosylceramidase beta 1",
        "frequency": "obligate",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/gba1"
      },
      {
        "slug": "gigyf2",
        "symbol": "GIGYF2",
        "hgnc": "HGNC:11960",
        "name": "GRB10 interacting GYF protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gigyf2"
      },
      {
        "slug": "lrrk2",
        "symbol": "LRRK2",
        "hgnc": "HGNC:18618",
        "name": "leucine rich repeat kinase 2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lrrk2"
      },
      {
        "slug": "mpv17",
        "symbol": "MPV17",
        "hgnc": "HGNC:7224",
        "name": "mitochondrial inner membrane protein MPV17",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpv17"
      },
      {
        "slug": "nr4a2",
        "symbol": "NR4A2",
        "hgnc": "HGNC:7981",
        "name": "nuclear receptor subfamily 4 group A member 2",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/nr4a2"
      },
      {
        "slug": "pla2g6",
        "symbol": "PLA2G6",
        "hgnc": "HGNC:9039",
        "name": "phospholipase A2 group VI",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pla2g6"
      },
      {
        "slug": "polg",
        "symbol": "POLG",
        "hgnc": "HGNC:9179",
        "name": "DNA polymerase gamma, catalytic subunit",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/polg"
      },
      {
        "slug": "prkn",
        "symbol": "PRKN",
        "hgnc": "HGNC:8607",
        "name": "parkin RBR E3 ubiquitin protein ligase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkn"
      },
      {
        "slug": "ptrhd1",
        "symbol": "PTRHD1",
        "hgnc": "HGNC:33782",
        "name": "peptidyl-tRNA hydrolase domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptrhd1"
      },
      {
        "slug": "rab32",
        "symbol": "RAB32",
        "hgnc": "HGNC:9772",
        "name": "RAB32, member RAS oncogene family",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab32"
      },
      {
        "slug": "rab39b",
        "symbol": "RAB39B",
        "hgnc": "HGNC:16499",
        "name": "RAB39B, member RAS oncogene family",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rab39b"
      },
      {
        "slug": "rnu2-2",
        "symbol": "RNU2-2",
        "hgnc": "HGNC:10152",
        "name": "RNA, U2 small nuclear 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu2-2"
      },
      {
        "slug": "slc18a2",
        "symbol": "SLC18A2",
        "hgnc": "HGNC:10935",
        "name": "solute carrier family 18 member A2",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc18a2"
      },
      {
        "slug": "slc9a6",
        "symbol": "SLC9A6",
        "hgnc": "HGNC:11079",
        "name": "solute carrier family 9 member A6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc9a6"
      },
      {
        "slug": "snca",
        "symbol": "SNCA",
        "hgnc": "HGNC:11138",
        "name": "synuclein alpha",
        "frequency": "obligate",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/snca"
      },
      {
        "slug": "synj1",
        "symbol": "SYNJ1",
        "hgnc": "HGNC:11503",
        "name": "synaptojanin 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/synj1"
      },
      {
        "slug": "vps35",
        "symbol": "VPS35",
        "hgnc": "HGNC:13487",
        "name": "VPS35 retromer complex component",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vps35"
      },
      {
        "slug": "app",
        "symbol": "APP",
        "hgnc": "HGNC:620",
        "name": "amyloid beta precursor protein",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/app"
      },
      {
        "slug": "atp13a2",
        "symbol": "ATP13A2",
        "hgnc": "HGNC:30213",
        "name": "ATPase cation transporting 13A2",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/atp13a2"
      },
      {
        "slug": "coasy",
        "symbol": "COASY",
        "hgnc": "HGNC:29932",
        "name": "Coenzyme A synthase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coasy"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "frequency": "very-frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "psen2",
        "symbol": "PSEN2",
        "hgnc": "HGNC:9509",
        "name": "presenilin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen2"
      },
      {
        "slug": "slc6a3",
        "symbol": "SLC6A3",
        "hgnc": "HGNC:11049",
        "name": "solute carrier family 6 member 3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc6a3"
      },
      {
        "slug": "sorl1",
        "symbol": "SORL1",
        "hgnc": "HGNC:11185",
        "name": "sortilin related receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sorl1"
      },
      {
        "slug": "tomm40",
        "symbol": "TOMM40",
        "hgnc": "HGNC:18001",
        "name": "translocase of outer mitochondrial membrane 40",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tomm40"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "wars2",
        "symbol": "WARS2",
        "hgnc": "HGNC:12730",
        "name": "tryptophanyl tRNA synthetase 2, mitochondrial",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wars2"
      },
      {
        "slug": "acbd6",
        "symbol": "ACBD6",
        "hgnc": "HGNC:23339",
        "name": "acyl-CoA binding domain containing 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acbd6"
      },
      {
        "slug": "aopep",
        "symbol": "AOPEP",
        "hgnc": "HGNC:1361",
        "name": "aminopeptidase O (putative)",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aopep"
      },
      {
        "slug": "atp1a3",
        "symbol": "ATP1A3",
        "hgnc": "HGNC:801",
        "name": "ATPase Na+/K+ transporting subunit alpha 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atp1a3"
      },
      {
        "slug": "c19orf12",
        "symbol": "C19orf12",
        "hgnc": "HGNC:25443",
        "name": "chromosome 19 open reading frame 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c19orf12"
      },
      {
        "slug": "chchd10",
        "symbol": "CHCHD10",
        "hgnc": "HGNC:15559",
        "name": "coiled-coil-helix-coiled-coil-helix domain containing 10",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chchd10"
      },
      {
        "slug": "coq2",
        "symbol": "COQ2",
        "hgnc": "HGNC:25223",
        "name": "coenzyme Q2, polyprenyltransferase",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/coq2"
      },
      {
        "slug": "eif2ak2",
        "symbol": "EIF2AK2",
        "hgnc": "HGNC:9437",
        "name": "eukaryotic translation initiation factor 2 alpha kinase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2ak2"
      },
      {
        "slug": "fus",
        "symbol": "FUS",
        "hgnc": "HGNC:4010",
        "name": "FUS RNA binding protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fus"
      },
      {
        "slug": "gabra1",
        "symbol": "GABRA1",
        "hgnc": "HGNC:4075",
        "name": "gamma-aminobutyric acid type A receptor subunit alpha1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabra1"
      },
      {
        "slug": "gabrg2",
        "symbol": "GABRG2",
        "hgnc": "HGNC:4087",
        "name": "gamma-aminobutyric acid type A receptor subunit gamma2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabrg2"
      },
      {
        "slug": "gch1",
        "symbol": "GCH1",
        "hgnc": "HGNC:4193",
        "name": "GTP cyclohydrolase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gch1"
      },
      {
        "slug": "impdh2",
        "symbol": "IMPDH2",
        "hgnc": "HGNC:6053",
        "name": "inosine monophosphate dehydrogenase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/impdh2"
      },
      {
        "slug": "jam2",
        "symbol": "JAM2",
        "hgnc": "HGNC:14686",
        "name": "junctional adhesion molecule 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/jam2"
      },
      {
        "slug": "mapt",
        "symbol": "MAPT",
        "hgnc": "HGNC:6893",
        "name": "microtubule associated protein tau",
        "frequency": "frequent",
        "diseases": 7,
        "url": "https://dantelabs.com/genes/mapt"
      },
      {
        "slug": "naa60",
        "symbol": "NAA60",
        "hgnc": "HGNC:25875",
        "name": "N-alpha-acetyltransferase 60, NatF catalytic subunit",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/naa60"
      },
      {
        "slug": "pank2",
        "symbol": "PANK2",
        "hgnc": "HGNC:15894",
        "name": "pantothenate kinase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pank2"
      },
      {
        "slug": "pcdh19",
        "symbol": "PCDH19",
        "hgnc": "HGNC:14270",
        "name": "protocadherin 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcdh19"
      },
      {
        "slug": "ppp2r2b",
        "symbol": "PPP2R2B",
        "hgnc": "HGNC:9305",
        "name": "protein phosphatase 2 regulatory subunit Bbeta",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ppp2r2b"
      },
      {
        "slug": "prkar1b",
        "symbol": "PRKAR1B",
        "hgnc": "HGNC:9390",
        "name": "protein kinase cAMP-dependent type I regulatory subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkar1b"
      },
      {
        "slug": "prkra",
        "symbol": "PRKRA",
        "hgnc": "HGNC:9438",
        "name": "protein activator of interferon induced protein kinase EIF2AK2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prkra"
      },
      {
        "slug": "prnp",
        "symbol": "PRNP",
        "hgnc": "HGNC:9449",
        "name": "prion protein (Kanno blood group)",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prnp"
      },
      {
        "slug": "scn1a",
        "symbol": "SCN1A",
        "hgnc": "HGNC:10585",
        "name": "sodium voltage-gated channel alpha subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1a"
      },
      {
        "slug": "scn1b",
        "symbol": "SCN1B",
        "hgnc": "HGNC:10586",
        "name": "sodium voltage-gated channel beta subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1b"
      },
      {
        "slug": "scn2a",
        "symbol": "SCN2A",
        "hgnc": "HGNC:10588",
        "name": "sodium voltage-gated channel alpha subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn2a"
      },
      {
        "slug": "scn9a",
        "symbol": "SCN9A",
        "hgnc": "HGNC:10597",
        "name": "sodium voltage-gated channel alpha subunit 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn9a"
      },
      {
        "slug": "slc39a14",
        "symbol": "SLC39A14",
        "hgnc": "HGNC:20858",
        "name": "solute carrier family 39 member 14",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc39a14"
      },
      {
        "slug": "sqstm1",
        "symbol": "SQSTM1",
        "hgnc": "HGNC:11280",
        "name": "sequestosome 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sqstm1"
      },
      {
        "slug": "stub1",
        "symbol": "STUB1",
        "hgnc": "HGNC:11427",
        "name": "STIP1 homology and U-box containing protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stub1"
      },
      {
        "slug": "tardbp",
        "symbol": "TARDBP",
        "hgnc": "HGNC:11571",
        "name": "TAR DNA binding protein",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tardbp"
      },
      {
        "slug": "tbk1",
        "symbol": "TBK1",
        "hgnc": "HGNC:11584",
        "name": "TANK binding kinase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbk1"
      },
      {
        "slug": "tbp",
        "symbol": "TBP",
        "hgnc": "HGNC:11588",
        "name": "TATA-box binding protein",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/tbp"
      },
      {
        "slug": "th",
        "symbol": "TH",
        "hgnc": "HGNC:11782",
        "name": "tyrosine hydroxylase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/th"
      },
      {
        "slug": "tspoap1",
        "symbol": "TSPOAP1",
        "hgnc": "HGNC:16831",
        "name": "TSPO associated protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tspoap1"
      },
      {
        "slug": "vcp",
        "symbol": "VCP",
        "hgnc": "HGNC:12666",
        "name": "valosin containing protein",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/vcp"
      },
      {
        "slug": "vps13a",
        "symbol": "VPS13A",
        "hgnc": "HGNC:1908",
        "name": "vacuolar protein sorting 13 homolog A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/vps13a"
      },
      {
        "slug": "wdr45",
        "symbol": "WDR45",
        "hgnc": "HGNC:28912",
        "name": "WD repeat domain 45",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wdr45"
      },
      {
        "slug": "afg3l2",
        "symbol": "AFG3L2",
        "hgnc": "HGNC:315",
        "name": "AFG3 like matrix AAA peptidase subunit 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/afg3l2"
      },
      {
        "slug": "als2",
        "symbol": "ALS2",
        "hgnc": "HGNC:443",
        "name": "alsin Rho guanine nucleotide exchange factor ALS2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/als2"
      },
      {
        "slug": "ap5z1",
        "symbol": "AP5Z1",
        "hgnc": "HGNC:22197",
        "name": "adaptor related protein complex 5 subunit zeta 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ap5z1"
      },
      {
        "slug": "arvcf",
        "symbol": "ARVCF",
        "hgnc": "HGNC:728",
        "name": "ARVCF delta catenin family member",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arvcf"
      },
      {
        "slug": "atxn2",
        "symbol": "ATXN2",
        "hgnc": "HGNC:10555",
        "name": "ataxin 2",
        "frequency": "occasional",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/atxn2"
      },
      {
        "slug": "atxn3",
        "symbol": "ATXN3",
        "hgnc": "HGNC:7106",
        "name": "ataxin 3",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/atxn3"
      },
      {
        "slug": "cbs",
        "symbol": "CBS",
        "hgnc": "HGNC:1550",
        "name": "cystathionine beta-synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbs"
      },
      {
        "slug": "chmp2b",
        "symbol": "CHMP2B",
        "hgnc": "HGNC:24537",
        "name": "charged multivesicular body protein 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chmp2b"
      },
      {
        "slug": "comt",
        "symbol": "COMT",
        "hgnc": "HGNC:2228",
        "name": "catechol-O-methyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/comt"
      },
      {
        "slug": "cp",
        "symbol": "CP",
        "hgnc": "HGNC:2295",
        "name": "ceruloplasmin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cp"
      },
      {
        "slug": "cyp27a1",
        "symbol": "CYP27A1",
        "hgnc": "HGNC:2605",
        "name": "cytochrome P450 family 27 subfamily A member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp27a1"
      },
      {
        "slug": "dnajc12",
        "symbol": "DNAJC12",
        "hgnc": "HGNC:28908",
        "name": "DnaJ heat shock protein family (Hsp40) member C12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc12"
      },
      {
        "slug": "erlin1",
        "symbol": "ERLIN1",
        "hgnc": "HGNC:16947",
        "name": "ER lipid raft associated 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erlin1"
      },
      {
        "slug": "ftl",
        "symbol": "FTL",
        "hgnc": "HGNC:3999",
        "name": "ferritin light chain",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ftl"
      },
      {
        "slug": "gne",
        "symbol": "GNE",
        "hgnc": "HGNC:23657",
        "name": "glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gne"
      },
      {
        "slug": "gp1bb",
        "symbol": "GP1BB",
        "hgnc": "HGNC:4440",
        "name": "glycoprotein Ib platelet subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gp1bb"
      },
      {
        "slug": "grn",
        "symbol": "GRN",
        "hgnc": "HGNC:4601",
        "name": "granulin precursor",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/grn"
      },
      {
        "slug": "hira",
        "symbol": "HIRA",
        "hgnc": "HGNC:4916",
        "name": "histone cell cycle regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hira"
      },
      {
        "slug": "hivep2",
        "symbol": "HIVEP2",
        "hgnc": "HGNC:4921",
        "name": "HIVEP zinc finger 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hivep2"
      },
      {
        "slug": "jmjd1c",
        "symbol": "JMJD1C",
        "hgnc": "HGNC:12313",
        "name": "jumonji domain containing 1C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jmjd1c"
      },
      {
        "slug": "jph3",
        "symbol": "JPH3",
        "hgnc": "HGNC:14203",
        "name": "junctophilin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jph3"
      },
      {
        "slug": "kcnn2",
        "symbol": "KCNN2",
        "hgnc": "HGNC:6291",
        "name": "potassium calcium-activated channel subfamily N member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnn2"
      },
      {
        "slug": "kif5a",
        "symbol": "KIF5A",
        "hgnc": "HGNC:6323",
        "name": "kinesin family member 5A",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kif5a"
      },
      {
        "slug": "lyst",
        "symbol": "LYST",
        "hgnc": "HGNC:1968",
        "name": "lysosomal trafficking regulator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lyst"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "myorg",
        "symbol": "MYORG",
        "hgnc": "HGNC:19918",
        "name": "myogenesis regulating glycosidase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/myorg"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "pdgfb",
        "symbol": "PDGFB",
        "hgnc": "HGNC:8800",
        "name": "platelet derived growth factor subunit B",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdgfb"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "rreb1",
        "symbol": "RREB1",
        "hgnc": "HGNC:10449",
        "name": "ras responsive element binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rreb1"
      },
      {
        "slug": "rrp12",
        "symbol": "RRP12",
        "hgnc": "HGNC:29100",
        "name": "ribosomal RNA processing 12 homolog",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rrp12"
      },
      {
        "slug": "sec24c",
        "symbol": "SEC24C",
        "hgnc": "HGNC:10705",
        "name": "SEC24 homolog C, COPII component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec24c"
      },
      {
        "slug": "sigmar1",
        "symbol": "SIGMAR1",
        "hgnc": "HGNC:8157",
        "name": "sigma receptor chaperone 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sigmar1"
      },
      {
        "slug": "slc20a2",
        "symbol": "SLC20A2",
        "hgnc": "HGNC:10947",
        "name": "solute carrier family 20 member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc20a2"
      },
      {
        "slug": "sord",
        "symbol": "SORD",
        "hgnc": "HGNC:11184",
        "name": "sorbitol dehydrogenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sord"
      },
      {
        "slug": "spg11",
        "symbol": "SPG11",
        "hgnc": "HGNC:11226",
        "name": "SPG11 vesicle trafficking associated, spatacsin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/spg11"
      },
      {
        "slug": "sptlc1",
        "symbol": "SPTLC1",
        "hgnc": "HGNC:11277",
        "name": "serine palmitoyltransferase long chain base subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc1"
      },
      {
        "slug": "sptlc2",
        "symbol": "SPTLC2",
        "hgnc": "HGNC:11278",
        "name": "serine palmitoyltransferase long chain base subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptlc2"
      },
      {
        "slug": "syne1",
        "symbol": "SYNE1",
        "hgnc": "HGNC:17089",
        "name": "spectrin repeat containing nuclear envelope protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syne1"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "tmem106b",
        "symbol": "TMEM106B",
        "hgnc": "HGNC:22407",
        "name": "transmembrane protein 106B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem106b"
      },
      {
        "slug": "trmt2b",
        "symbol": "TRMT2B",
        "hgnc": "HGNC:25748",
        "name": "tRNA methyltransferase 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trmt2b"
      },
      {
        "slug": "ubqln2",
        "symbol": "UBQLN2",
        "hgnc": "HGNC:12509",
        "name": "ubiquilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubqln2"
      },
      {
        "slug": "ubtf",
        "symbol": "UBTF",
        "hgnc": "HGNC:12511",
        "name": "upstream binding transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubtf"
      },
      {
        "slug": "ufd1",
        "symbol": "UFD1",
        "hgnc": "HGNC:12520",
        "name": "ubiquitin recognition factor in ER associated degradation 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ufd1"
      },
      {
        "slug": "xpr1",
        "symbol": "XPR1",
        "hgnc": "HGNC:12827",
        "name": "xenotropic and polytropic retrovirus receptor 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/xpr1"
      },
      {
        "slug": "atn1",
        "symbol": "ATN1",
        "hgnc": "HGNC:3033",
        "name": "atrophin 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atn1"
      },
      {
        "slug": "cat",
        "symbol": "CAT",
        "hgnc": "HGNC:1516",
        "name": "catalase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cat"
      },
      {
        "slug": "pcbd1",
        "symbol": "PCBD1",
        "hgnc": "HGNC:8646",
        "name": "pterin-4 alpha-carbinolamine dehydratase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcbd1"
      },
      {
        "slug": "scarb2",
        "symbol": "SCARB2",
        "hgnc": "HGNC:1665",
        "name": "scavenger receptor class B member 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scarb2"
      },
      {
        "slug": "twnk",
        "symbol": "TWNK",
        "hgnc": "HGNC:1160",
        "name": "twinkle mtDNA helicase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twnk"
      },
      {
        "slug": "adh1c",
        "symbol": "ADH1C",
        "hgnc": "HGNC:251",
        "name": "alcohol dehydrogenase 1C (class I), gamma polypeptide",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adh1c"
      },
      {
        "slug": "apoe",
        "symbol": "APOE",
        "hgnc": "HGNC:613",
        "name": "apolipoprotein E",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apoe"
      },
      {
        "slug": "atxn8os",
        "symbol": "ATXN8OS",
        "hgnc": "HGNC:10561",
        "name": "ATXN8 opposite strand lncRNA",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn8os"
      },
      {
        "slug": "c9orf72",
        "symbol": "C9orf72",
        "hgnc": "HGNC:28337",
        "name": "C9orf72-SMCR8 complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c9orf72"
      },
      {
        "slug": "dnajc5",
        "symbol": "DNAJC5",
        "hgnc": "HGNC:16235",
        "name": "DnaJ heat shock protein family (Hsp40) member C5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc5"
      },
      {
        "slug": "dnajc6",
        "symbol": "DNAJC6",
        "hgnc": "HGNC:15469",
        "name": "DnaJ heat shock protein family (Hsp40) member C6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc6"
      },
      {
        "slug": "mpo",
        "symbol": "MPO",
        "hgnc": "HGNC:7218",
        "name": "myeloperoxidase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpo"
      },
      {
        "slug": "mt-tt",
        "symbol": "MT-TT",
        "hgnc": "HGNC:7499",
        "name": "mitochondrially encoded tRNA-Thr (ACN)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mt-tt"
      },
      {
        "slug": "pde10a",
        "symbol": "PDE10A",
        "hgnc": "HGNC:8772",
        "name": "phosphodiesterase 10A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pde10a"
      },
      {
        "slug": "pink1",
        "symbol": "PINK1",
        "hgnc": "HGNC:14581",
        "name": "PTEN induced kinase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pink1"
      },
      {
        "slug": "plau",
        "symbol": "PLAU",
        "hgnc": "HGNC:9052",
        "name": "plasminogen activator, urokinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plau"
      },
      {
        "slug": "pts",
        "symbol": "PTS",
        "hgnc": "HGNC:9689",
        "name": "6-pyruvoyltetrahydropterin synthase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pts"
      },
      {
        "slug": "slc30a10",
        "symbol": "SLC30A10",
        "hgnc": "HGNC:25355",
        "name": "solute carrier family 30 member 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc30a10"
      },
      {
        "slug": "sncaip",
        "symbol": "SNCAIP",
        "hgnc": "HGNC:11139",
        "name": "synuclein alpha interacting protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sncaip"
      },
      {
        "slug": "sncb",
        "symbol": "SNCB",
        "hgnc": "HGNC:11140",
        "name": "synuclein beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sncb"
      },
      {
        "slug": "tmem240",
        "symbol": "TMEM240",
        "hgnc": "HGNC:25186",
        "name": "transmembrane protein 240",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem240"
      },
      {
        "slug": "tnr",
        "symbol": "TNR",
        "hgnc": "HGNC:11953",
        "name": "tenascin R",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnr"
      }
    ]
  }
}