{
  "url": "https://dantelabs.com/traits/palpebral-edema",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "palpebral-edema",
    "id": "HP:0100540",
    "name": "Fullness of eyelids",
    "label": "Palpebral edema",
    "definition": "Edema in the region of the eyelids.",
    "synonyms": [
      "Puffy eyelids",
      "Puffy lids",
      "Swelling of eyelids",
      "Edema of the eyelids",
      "Eyelid edema",
      "Eyelid oedema",
      "Oedema of the eyelids",
      "Palpebral oedema"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-eyelid-morphology",
        "name": "Abnormality of the eyelid",
        "url": "https://dantelabs.com/traits/abnormal-eyelid-morphology"
      },
      {
        "slug": "periorbital-edema",
        "name": "Periorbital edema",
        "url": "https://dantelabs.com/traits/periorbital-edema"
      }
    ],
    "narrower": [
      {
        "slug": "blepharochalasis",
        "name": "Blepharochalasis",
        "genes": 8,
        "url": "https://dantelabs.com/traits/blepharochalasis"
      },
      {
        "slug": "upper-eyelid-edema",
        "name": "Fullness of upper eyelid",
        "genes": 6,
        "url": "https://dantelabs.com/traits/upper-eyelid-edema"
      }
    ],
    "genes": [
      {
        "slug": "rin2",
        "symbol": "RIN2",
        "hgnc": "HGNC:18750",
        "name": "Ras and Rab interactor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rin2"
      },
      {
        "slug": "antxr1",
        "symbol": "ANTXR1",
        "hgnc": "HGNC:21014",
        "name": "ANTXR cell adhesion molecule 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/antxr1"
      },
      {
        "slug": "rbmx",
        "symbol": "RBMX",
        "hgnc": "HGNC:9910",
        "name": "RNA binding motif protein X-linked",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbmx"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "cachd1",
        "symbol": "CACHD1",
        "hgnc": "HGNC:29314",
        "name": "cache domain containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cachd1"
      },
      {
        "slug": "foxg1",
        "symbol": "FOXG1",
        "hgnc": "HGNC:3811",
        "name": "forkhead box G1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxg1"
      },
      {
        "slug": "frmd4a",
        "symbol": "FRMD4A",
        "hgnc": "HGNC:25491",
        "name": "FERM domain containing 4A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frmd4a"
      },
      {
        "slug": "gpr101",
        "symbol": "GPR101",
        "hgnc": "HGNC:14963",
        "name": "G protein-coupled receptor 101",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr101"
      },
      {
        "slug": "kctd1",
        "symbol": "KCTD1",
        "hgnc": "HGNC:18249",
        "name": "potassium channel tetramerization domain containing 1",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kctd1"
      },
      {
        "slug": "knstrn",
        "symbol": "KNSTRN",
        "hgnc": "HGNC:30767",
        "name": "kinetochore localized astrin (SPAG5) binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/knstrn"
      },
      {
        "slug": "med16",
        "symbol": "MED16",
        "hgnc": "HGNC:17556",
        "name": "mediator complex subunit 16",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med16"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "shank3",
        "symbol": "SHANK3",
        "hgnc": "HGNC:14294",
        "name": "SH3 and multiple ankyrin repeat domains 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shank3"
      },
      {
        "slug": "snx14",
        "symbol": "SNX14",
        "hgnc": "HGNC:14977",
        "name": "sorting nexin 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snx14"
      },
      {
        "slug": "sox18",
        "symbol": "SOX18",
        "hgnc": "HGNC:11194",
        "name": "SRY-box transcription factor 18",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/sox18"
      },
      {
        "slug": "tgfbi",
        "symbol": "TGFBI",
        "hgnc": "HGNC:11771",
        "name": "transforming growth factor beta induced",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfbi"
      },
      {
        "slug": "xpnpep2",
        "symbol": "XPNPEP2",
        "hgnc": "HGNC:12823",
        "name": "X-prolyl aminopeptidase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xpnpep2"
      },
      {
        "slug": "znhit3",
        "symbol": "ZNHIT3",
        "hgnc": "HGNC:12309",
        "name": "zinc finger HIT-type containing 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znhit3"
      },
      {
        "slug": "actb",
        "symbol": "ACTB",
        "hgnc": "HGNC:132",
        "name": "actin beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actb"
      },
      {
        "slug": "actg1",
        "symbol": "ACTG1",
        "hgnc": "HGNC:144",
        "name": "actin gamma 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actg1"
      },
      {
        "slug": "camta1",
        "symbol": "CAMTA1",
        "hgnc": "HGNC:18806",
        "name": "calmodulin binding transcription activator 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/camta1"
      },
      {
        "slug": "kptn",
        "symbol": "KPTN",
        "hgnc": "HGNC:6404",
        "name": "kaptin, actin binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kptn"
      },
      {
        "slug": "psph",
        "symbol": "PSPH",
        "hgnc": "HGNC:9577",
        "name": "phosphoserine phosphatase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psph"
      },
      {
        "slug": "slc35c1",
        "symbol": "SLC35C1",
        "hgnc": "HGNC:20197",
        "name": "solute carrier family 35 member C1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35c1"
      },
      {
        "slug": "pou4f1",
        "symbol": "POU4F1",
        "hgnc": "HGNC:9218",
        "name": "POU class 4 homeobox 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pou4f1"
      },
      {
        "slug": "sptbn1",
        "symbol": "SPTBN1",
        "hgnc": "HGNC:11275",
        "name": "spectrin beta, non-erythrocytic 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sptbn1"
      },
      {
        "slug": "gnptab",
        "symbol": "GNPTAB",
        "hgnc": "HGNC:29670",
        "name": "N-acetylglucosamine-1-phosphate transferase subunits alpha and beta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnptab"
      },
      {
        "slug": "pex2",
        "symbol": "PEX2",
        "hgnc": "HGNC:9717",
        "name": "peroxisomal biogenesis factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex2"
      },
      {
        "slug": "pex5",
        "symbol": "PEX5",
        "hgnc": "HGNC:9719",
        "name": "peroxisomal biogenesis factor 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex5"
      }
    ]
  }
}