{
  "url": "https://dantelabs.com/traits/palmar-pruritus",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "palmar-pruritus",
    "id": "HP:0031248",
    "name": "Itchy palm",
    "label": "Palmar pruritus",
    "definition": "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the palm(s) of the hand.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "pruritis-on-hand",
        "name": "Pruritis on hand",
        "url": "https://dantelabs.com/traits/pruritis-on-hand"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "abcb11",
        "symbol": "ABCB11",
        "hgnc": "HGNC:42",
        "name": "ATP binding cassette subfamily B member 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb11"
      },
      {
        "slug": "abcb4",
        "symbol": "ABCB4",
        "hgnc": "HGNC:45",
        "name": "ATP binding cassette subfamily B member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcb4"
      },
      {
        "slug": "atp8b1",
        "symbol": "ATP8B1",
        "hgnc": "HGNC:3706",
        "name": "ATPase phospholipid transporting 8B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp8b1"
      },
      {
        "slug": "nr1h4",
        "symbol": "NR1H4",
        "hgnc": "HGNC:7967",
        "name": "nuclear receptor subfamily 1 group H member 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr1h4"
      }
    ]
  }
}