{
  "url": "https://dantelabs.com/traits/optic-nerve-hypoplasia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "optic-nerve-hypoplasia",
    "id": "HP:0000609",
    "name": "Optic nerve hypoplasia",
    "definition": "Underdevelopment of the optic nerve.",
    "synonyms": [
      "Hypoplastic optic nerves",
      "Underdeveloped optic nerves"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-of-the-optic-nerve",
        "name": "Absent/small optic nerve",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-optic-nerve"
      },
      {
        "slug": "aplasia-hypoplasia-involving-the-central-nervous-system",
        "name": "Absent/underdeveloped central nervous system tissue",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-involving-the-central-nervous-system"
      }
    ],
    "narrower": [
      {
        "slug": "septo-optic-dysplasia",
        "name": "Septo-optic dysplasia",
        "genes": 24,
        "url": "https://dantelabs.com/traits/septo-optic-dysplasia"
      }
    ],
    "genes": [
      {
        "slug": "asns",
        "symbol": "ASNS",
        "hgnc": "HGNC:753",
        "name": "asparagine synthetase (glutamine-hydrolyzing)",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/asns"
      },
      {
        "slug": "cacna1c",
        "symbol": "CACNA1C",
        "hgnc": "HGNC:1390",
        "name": "calcium voltage-gated channel subunit alpha1 C",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1c"
      },
      {
        "slug": "chaserr",
        "symbol": "CHASERR",
        "hgnc": "HGNC:48626",
        "name": "CHD2 adjacent suppressive regulatory RNA",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chaserr"
      },
      {
        "slug": "eif4a2",
        "symbol": "EIF4A2",
        "hgnc": "HGNC:3284",
        "name": "eukaryotic translation initiation factor 4A2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif4a2"
      },
      {
        "slug": "fdxr",
        "symbol": "FDXR",
        "hgnc": "HGNC:3642",
        "name": "ferredoxin reductase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdxr"
      },
      {
        "slug": "gnpat",
        "symbol": "GNPAT",
        "hgnc": "HGNC:4416",
        "name": "glyceronephosphate O-acyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gnpat"
      },
      {
        "slug": "hmbs",
        "symbol": "HMBS",
        "hgnc": "HGNC:4982",
        "name": "hydroxymethylbilane synthase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmbs"
      },
      {
        "slug": "map2k2",
        "symbol": "MAP2K2",
        "hgnc": "HGNC:6842",
        "name": "mitogen-activated protein kinase kinase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map2k2"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "ptf1a",
        "symbol": "PTF1A",
        "hgnc": "HGNC:23734",
        "name": "pancreas associated transcription factor 1a",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ptf1a"
      },
      {
        "slug": "ptpn23",
        "symbol": "PTPN23",
        "hgnc": "HGNC:14406",
        "name": "protein tyrosine phosphatase non-receptor type 23",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn23"
      },
      {
        "slug": "rbsn",
        "symbol": "RBSN",
        "hgnc": "HGNC:20759",
        "name": "rabenosyn, RAB effector",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbsn"
      },
      {
        "slug": "rere",
        "symbol": "RERE",
        "hgnc": "HGNC:9965",
        "name": "arginine-glutamic acid dipeptide repeats",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rere"
      },
      {
        "slug": "scn8a",
        "symbol": "SCN8A",
        "hgnc": "HGNC:10596",
        "name": "sodium voltage-gated channel alpha subunit 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn8a"
      },
      {
        "slug": "snf8",
        "symbol": "SNF8",
        "hgnc": "HGNC:17028",
        "name": "SNF8 subunit of ESCRT-II",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snf8"
      },
      {
        "slug": "yme1l1",
        "symbol": "YME1L1",
        "hgnc": "HGNC:12843",
        "name": "YME1 like 1 ATPase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yme1l1"
      },
      {
        "slug": "arnt2",
        "symbol": "ARNT2",
        "hgnc": "HGNC:16876",
        "name": "aryl hydrocarbon receptor nuclear translocator 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arnt2"
      },
      {
        "slug": "bcl11a",
        "symbol": "BCL11A",
        "hgnc": "HGNC:13221",
        "name": "BCL11 transcription factor A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcl11a"
      },
      {
        "slug": "epg5",
        "symbol": "EPG5",
        "hgnc": "HGNC:29331",
        "name": "ectopic P-granules 5 autophagy tethering factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epg5"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "hesx1",
        "symbol": "HESX1",
        "hgnc": "HGNC:4877",
        "name": "HESX homeobox 1",
        "frequency": "very-frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/hesx1"
      },
      {
        "slug": "mbtps2",
        "symbol": "MBTPS2",
        "hgnc": "HGNC:15455",
        "name": "membrane bound transcription factor peptidase, site 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbtps2"
      },
      {
        "slug": "prokr2",
        "symbol": "PROKR2",
        "hgnc": "HGNC:15836",
        "name": "prokineticin receptor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prokr2"
      },
      {
        "slug": "rel",
        "symbol": "REL",
        "hgnc": "HGNC:9954",
        "name": "REL proto-oncogene, NF-kB subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rel"
      },
      {
        "slug": "sox2",
        "symbol": "SOX2",
        "hgnc": "HGNC:11195",
        "name": "SRY-box transcription factor 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sox2"
      },
      {
        "slug": "sox3",
        "symbol": "SOX3",
        "hgnc": "HGNC:11199",
        "name": "SRY-box transcription factor 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox3"
      },
      {
        "slug": "tuba8",
        "symbol": "TUBA8",
        "hgnc": "HGNC:12410",
        "name": "tubulin alpha 8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tuba8"
      },
      {
        "slug": "xpo1",
        "symbol": "XPO1",
        "hgnc": "HGNC:12825",
        "name": "exportin 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xpo1"
      },
      {
        "slug": "aass",
        "symbol": "AASS",
        "hgnc": "HGNC:17366",
        "name": "aminoadipate-semialdehyde synthase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aass"
      },
      {
        "slug": "aldh1a2",
        "symbol": "ALDH1A2",
        "hgnc": "HGNC:15472",
        "name": "aldehyde dehydrogenase 1 family member A2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh1a2"
      },
      {
        "slug": "aldh1a3",
        "symbol": "ALDH1A3",
        "hgnc": "HGNC:409",
        "name": "aldehyde dehydrogenase 1 family member A3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aldh1a3"
      },
      {
        "slug": "ankrd11",
        "symbol": "ANKRD11",
        "hgnc": "HGNC:21316",
        "name": "ankyrin repeat domain 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ankrd11"
      },
      {
        "slug": "cct3",
        "symbol": "CCT3",
        "hgnc": "HGNC:1616",
        "name": "chaperonin containing TCP1 subunit 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cct3"
      },
      {
        "slug": "crppa",
        "symbol": "CRPPA",
        "hgnc": "HGNC:37276",
        "name": "CDP-L-ribitol pyrophosphorylase A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crppa"
      },
      {
        "slug": "ddhd2",
        "symbol": "DDHD2",
        "hgnc": "HGNC:29106",
        "name": "DDHD domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddhd2"
      },
      {
        "slug": "erf",
        "symbol": "ERF",
        "hgnc": "HGNC:3444",
        "name": "ETS2 repressor factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/erf"
      },
      {
        "slug": "fanci",
        "symbol": "FANCI",
        "hgnc": "HGNC:25568",
        "name": "FA complementation group I",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fanci"
      },
      {
        "slug": "fdft1",
        "symbol": "FDFT1",
        "hgnc": "HGNC:3629",
        "name": "farnesyl-diphosphate farnesyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fdft1"
      },
      {
        "slug": "glyctk",
        "symbol": "GLYCTK",
        "hgnc": "HGNC:24247",
        "name": "glycerate kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glyctk"
      },
      {
        "slug": "ift74",
        "symbol": "IFT74",
        "hgnc": "HGNC:21424",
        "name": "intraflagellar transport 74",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift74"
      },
      {
        "slug": "kcnk4",
        "symbol": "KCNK4",
        "hgnc": "HGNC:6279",
        "name": "potassium two pore domain channel subfamily K member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnk4"
      },
      {
        "slug": "kif14",
        "symbol": "KIF14",
        "hgnc": "HGNC:19181",
        "name": "kinesin family member 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif14"
      },
      {
        "slug": "knstrn",
        "symbol": "KNSTRN",
        "hgnc": "HGNC:30767",
        "name": "kinetochore localized astrin (SPAG5) binding protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/knstrn"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "nfix",
        "symbol": "NFIX",
        "hgnc": "HGNC:7788",
        "name": "nuclear factor I X",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfix"
      },
      {
        "slug": "pax6",
        "symbol": "PAX6",
        "hgnc": "HGNC:8620",
        "name": "paired box 6",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/pax6"
      },
      {
        "slug": "pik3cd",
        "symbol": "PIK3CD",
        "hgnc": "HGNC:8977",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3cd"
      },
      {
        "slug": "pogz",
        "symbol": "POGZ",
        "hgnc": "HGNC:18801",
        "name": "pogo transposable element derived with ZNF domain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pogz"
      },
      {
        "slug": "puf60",
        "symbol": "PUF60",
        "hgnc": "HGNC:17042",
        "name": "poly(U) binding splicing factor 60",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/puf60"
      },
      {
        "slug": "rnf113a",
        "symbol": "RNF113A",
        "hgnc": "HGNC:12974",
        "name": "ring finger protein 113A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf113a"
      },
      {
        "slug": "rragc",
        "symbol": "RRAGC",
        "hgnc": "HGNC:19902",
        "name": "Ras related GTP binding C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rragc"
      },
      {
        "slug": "setd2",
        "symbol": "SETD2",
        "hgnc": "HGNC:18420",
        "name": "SET domain containing 2, histone lysine methyltransferase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setd2"
      },
      {
        "slug": "spop",
        "symbol": "SPOP",
        "hgnc": "HGNC:11254",
        "name": "speckle type BTB/POZ protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spop"
      },
      {
        "slug": "zswim6",
        "symbol": "ZSWIM6",
        "hgnc": "HGNC:29316",
        "name": "zinc finger SWIM-type containing 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zswim6"
      },
      {
        "slug": "armc9",
        "symbol": "ARMC9",
        "hgnc": "HGNC:20730",
        "name": "armadillo repeat containing 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/armc9"
      },
      {
        "slug": "atad3a",
        "symbol": "ATAD3A",
        "hgnc": "HGNC:25567",
        "name": "ATPase family AAA domain containing 3A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atad3a"
      },
      {
        "slug": "b3galnt2",
        "symbol": "B3GALNT2",
        "hgnc": "HGNC:28596",
        "name": "beta-1,3-N-acetylgalactosaminyltransferase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b3galnt2"
      },
      {
        "slug": "cask",
        "symbol": "CASK",
        "hgnc": "HGNC:1497",
        "name": "calcium/calmodulin dependent serine protein kinase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cask"
      },
      {
        "slug": "cep85l",
        "symbol": "CEP85L",
        "hgnc": "HGNC:21638",
        "name": "centrosomal protein 85L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep85l"
      },
      {
        "slug": "col25a1",
        "symbol": "COL25A1",
        "hgnc": "HGNC:18603",
        "name": "collagen type XXV alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col25a1"
      },
      {
        "slug": "dot1l",
        "symbol": "DOT1L",
        "hgnc": "HGNC:24948",
        "name": "DOT1 like histone lysine methyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dot1l"
      },
      {
        "slug": "eefsec",
        "symbol": "EEFSEC",
        "hgnc": "HGNC:24614",
        "name": "eukaryotic elongation factor, selenocysteine-tRNA specific",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eefsec"
      },
      {
        "slug": "fkrp",
        "symbol": "FKRP",
        "hgnc": "HGNC:17997",
        "name": "fukutin related protein",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fkrp"
      },
      {
        "slug": "foxc1",
        "symbol": "FOXC1",
        "hgnc": "HGNC:3800",
        "name": "forkhead box C1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxc1"
      },
      {
        "slug": "gabbr1",
        "symbol": "GABBR1",
        "hgnc": "HGNC:4070",
        "name": "gamma-aminobutyric acid type B receptor subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gabbr1"
      },
      {
        "slug": "gatad2b",
        "symbol": "GATAD2B",
        "hgnc": "HGNC:30778",
        "name": "GATA zinc finger domain containing 2B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gatad2b"
      },
      {
        "slug": "gli2",
        "symbol": "GLI2",
        "hgnc": "HGNC:4318",
        "name": "GLI family zinc finger 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gli2"
      },
      {
        "slug": "gmppb",
        "symbol": "GMPPB",
        "hgnc": "HGNC:22932",
        "name": "GDP-mannose pyrophosphorylase B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gmppb"
      },
      {
        "slug": "gria4",
        "symbol": "GRIA4",
        "hgnc": "HGNC:4574",
        "name": "glutamate ionotropic receptor AMPA type subunit 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gria4"
      },
      {
        "slug": "hnrnpk",
        "symbol": "HNRNPK",
        "hgnc": "HGNC:5044",
        "name": "heterogeneous nuclear ribonucleoprotein K",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnrnpk"
      },
      {
        "slug": "inpp4a",
        "symbol": "INPP4A",
        "hgnc": "HGNC:6074",
        "name": "inositol polyphosphate-4-phosphatase type I A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp4a"
      },
      {
        "slug": "kif21a",
        "symbol": "KIF21A",
        "hgnc": "HGNC:19349",
        "name": "kinesin family member 21A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif21a"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "hgnc": "HGNC:6487",
        "name": "laminin subunit beta 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb2"
      },
      {
        "slug": "lhx3",
        "symbol": "LHX3",
        "hgnc": "HGNC:6595",
        "name": "LIM homeobox 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx3"
      },
      {
        "slug": "lhx4",
        "symbol": "LHX4",
        "hgnc": "HGNC:21734",
        "name": "LIM homeobox 4",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lhx4"
      },
      {
        "slug": "mab21l1",
        "symbol": "MAB21L1",
        "hgnc": "HGNC:6757",
        "name": "mab-21 like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mab21l1"
      },
      {
        "slug": "macf1",
        "symbol": "MACF1",
        "hgnc": "HGNC:13664",
        "name": "microtubule actin crosslinking factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/macf1"
      },
      {
        "slug": "mef2c",
        "symbol": "MEF2C",
        "hgnc": "HGNC:6996",
        "name": "myocyte enhancer factor 2C",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mef2c"
      },
      {
        "slug": "nde1",
        "symbol": "NDE1",
        "hgnc": "HGNC:17619",
        "name": "nudE neurodevelopment protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nde1"
      },
      {
        "slug": "nefl",
        "symbol": "NEFL",
        "hgnc": "HGNC:7739",
        "name": "neurofilament light chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nefl"
      },
      {
        "slug": "nr2f1",
        "symbol": "NR2F1",
        "hgnc": "HGNC:7975",
        "name": "nuclear receptor subfamily 2 group F member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr2f1"
      },
      {
        "slug": "otud5",
        "symbol": "OTUD5",
        "hgnc": "HGNC:25402",
        "name": "OTU deubiquitinase 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otud5"
      },
      {
        "slug": "phox2a",
        "symbol": "PHOX2A",
        "hgnc": "HGNC:691",
        "name": "paired like homeobox 2A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phox2a"
      },
      {
        "slug": "pomgnt1",
        "symbol": "POMGNT1",
        "hgnc": "HGNC:19139",
        "name": "protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomgnt1"
      },
      {
        "slug": "pomk",
        "symbol": "POMK",
        "hgnc": "HGNC:26267",
        "name": "protein O-mannose kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomk"
      },
      {
        "slug": "pomt1",
        "symbol": "POMT1",
        "hgnc": "HGNC:9202",
        "name": "protein O-mannosyltransferase 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pomt1"
      },
      {
        "slug": "pomt2",
        "symbol": "POMT2",
        "hgnc": "HGNC:19743",
        "name": "protein O-mannosyltransferase 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pomt2"
      },
      {
        "slug": "pou1f1",
        "symbol": "POU1F1",
        "hgnc": "HGNC:9210",
        "name": "POU class 1 homeobox 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pou1f1"
      },
      {
        "slug": "ppp1cb",
        "symbol": "PPP1CB",
        "hgnc": "HGNC:9282",
        "name": "protein phosphatase 1 catalytic subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1cb"
      },
      {
        "slug": "ppp2r1a",
        "symbol": "PPP2R1A",
        "hgnc": "HGNC:9302",
        "name": "protein phosphatase 2 scaffold subunit Aalpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp2r1a"
      },
      {
        "slug": "prop1",
        "symbol": "PROP1",
        "hgnc": "HGNC:9455",
        "name": "PROP paired-like homeobox 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/prop1"
      },
      {
        "slug": "recql4",
        "symbol": "RECQL4",
        "hgnc": "HGNC:9949",
        "name": "RecQ like helicase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/recql4"
      },
      {
        "slug": "rfx7",
        "symbol": "RFX7",
        "hgnc": "HGNC:25777",
        "name": "regulatory factor X7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx7"
      },
      {
        "slug": "rnf135",
        "symbol": "RNF135",
        "hgnc": "HGNC:21158",
        "name": "ring finger protein 135",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf135"
      },
      {
        "slug": "rnu4-2",
        "symbol": "RNU4-2",
        "hgnc": "HGNC:10193",
        "name": "RNA, U4 small nuclear 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu4-2"
      },
      {
        "slug": "rttn",
        "symbol": "RTTN",
        "hgnc": "HGNC:18654",
        "name": "rotatin",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rttn"
      },
      {
        "slug": "son",
        "symbol": "SON",
        "hgnc": "HGNC:11183",
        "name": "SON DNA and RNA binding protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/son"
      },
      {
        "slug": "stag2",
        "symbol": "STAG2",
        "hgnc": "HGNC:11355",
        "name": "STAG2 cohesin complex component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stag2"
      },
      {
        "slug": "trim44",
        "symbol": "TRIM44",
        "hgnc": "HGNC:19016",
        "name": "TRIM family member 44",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trim44"
      },
      {
        "slug": "tuba1a",
        "symbol": "TUBA1A",
        "hgnc": "HGNC:20766",
        "name": "tubulin alpha 1a",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tuba1a"
      },
      {
        "slug": "tubb2b",
        "symbol": "TUBB2B",
        "hgnc": "HGNC:30829",
        "name": "tubulin beta 2B class IIb",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb2b"
      },
      {
        "slug": "tubb3",
        "symbol": "TUBB3",
        "hgnc": "HGNC:20772",
        "name": "tubulin beta 3 class III",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tubb3"
      },
      {
        "slug": "wsb2",
        "symbol": "WSB2",
        "hgnc": "HGNC:19222",
        "name": "WD repeat and SOCS box containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wsb2"
      },
      {
        "slug": "zfx",
        "symbol": "ZFX",
        "hgnc": "HGNC:12869",
        "name": "zinc finger protein X-linked",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfx"
      },
      {
        "slug": "zic1",
        "symbol": "ZIC1",
        "hgnc": "HGNC:12872",
        "name": "Zic family zinc finger 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zic1"
      },
      {
        "slug": "zpr1",
        "symbol": "ZPR1",
        "hgnc": "HGNC:13051",
        "name": "ZPR1 zinc finger",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zpr1"
      },
      {
        "slug": "arsl",
        "symbol": "ARSL",
        "hgnc": "HGNC:719",
        "name": "arylsulfatase L",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arsl"
      },
      {
        "slug": "foxa2",
        "symbol": "FOXA2",
        "hgnc": "HGNC:5022",
        "name": "forkhead box A2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxa2"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "med16",
        "symbol": "MED16",
        "hgnc": "HGNC:17556",
        "name": "mediator complex subunit 16",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med16"
      },
      {
        "slug": "cenpf",
        "symbol": "CENPF",
        "hgnc": "HGNC:1857",
        "name": "centromere protein F",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cenpf"
      },
      {
        "slug": "dnmt3a",
        "symbol": "DNMT3A",
        "hgnc": "HGNC:2978",
        "name": "DNA methyltransferase 3 alpha",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnmt3a"
      },
      {
        "slug": "fktn",
        "symbol": "FKTN",
        "hgnc": "HGNC:3622",
        "name": "fukutin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fktn"
      },
      {
        "slug": "large1",
        "symbol": "LARGE1",
        "hgnc": "HGNC:6511",
        "name": "LARGE xylosyl- and glucuronyltransferase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/large1"
      },
      {
        "slug": "six6",
        "symbol": "SIX6",
        "hgnc": "HGNC:10892",
        "name": "SIX homeobox 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/six6"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wt1"
      }
    ]
  }
}