{
  "url": "https://dantelabs.com/traits/neonatal-hypoglycemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "neonatal-hypoglycemia",
    "id": "HP:0001998",
    "name": "Low blood sugar in newborn",
    "label": "Neonatal hypoglycemia",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "hypoglycemia",
        "name": "Low blood sugar",
        "url": "https://dantelabs.com/traits/hypoglycemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "nsd1",
        "symbol": "NSD1",
        "hgnc": "HGNC:14234",
        "name": "nuclear receptor binding SET domain protein 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nsd1"
      },
      {
        "slug": "otx2",
        "symbol": "OTX2",
        "hgnc": "HGNC:8522",
        "name": "orthodenticle homeobox 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/otx2"
      },
      {
        "slug": "slc25a20",
        "symbol": "SLC25A20",
        "hgnc": "HGNC:1421",
        "name": "solute carrier family 25 member 20",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc25a20"
      },
      {
        "slug": "tbx19",
        "symbol": "TBX19",
        "hgnc": "HGNC:11596",
        "name": "T-box transcription factor 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx19"
      },
      {
        "slug": "yars1",
        "symbol": "YARS1",
        "hgnc": "HGNC:12840",
        "name": "tyrosyl-tRNA synthetase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yars1"
      },
      {
        "slug": "akt2",
        "symbol": "AKT2",
        "hgnc": "HGNC:392",
        "name": "AKT serine/threonine kinase 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/akt2"
      },
      {
        "slug": "cyp11a1",
        "symbol": "CYP11A1",
        "hgnc": "HGNC:2590",
        "name": "cytochrome P450 family 11 subfamily A member 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cyp11a1"
      },
      {
        "slug": "hadh",
        "symbol": "HADH",
        "hgnc": "HGNC:4799",
        "name": "hydroxyacyl-CoA dehydrogenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hadh"
      },
      {
        "slug": "hnf1a",
        "symbol": "HNF1A",
        "hgnc": "HGNC:11621",
        "name": "HNF1 homeobox A",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnf1a"
      },
      {
        "slug": "hnf4a",
        "symbol": "HNF4A",
        "hgnc": "HGNC:5024",
        "name": "hepatocyte nuclear factor 4 alpha",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hnf4a"
      },
      {
        "slug": "msl3",
        "symbol": "MSL3",
        "hgnc": "HGNC:7370",
        "name": "MSL complex subunit 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msl3"
      },
      {
        "slug": "cox10",
        "symbol": "COX10",
        "hgnc": "HGNC:2260",
        "name": "cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cox10"
      },
      {
        "slug": "hsd3b2",
        "symbol": "HSD3B2",
        "hgnc": "HGNC:5218",
        "name": "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd3b2"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "madd",
        "symbol": "MADD",
        "hgnc": "HGNC:6766",
        "name": "MAP kinase activating death domain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/madd"
      },
      {
        "slug": "nos3",
        "symbol": "NOS3",
        "hgnc": "HGNC:7876",
        "name": "nitric oxide synthase 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nos3"
      },
      {
        "slug": "serac1",
        "symbol": "SERAC1",
        "hgnc": "HGNC:21061",
        "name": "serine active site containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serac1"
      },
      {
        "slug": "zrsr2",
        "symbol": "ZRSR2",
        "hgnc": "HGNC:23019",
        "name": "zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zrsr2"
      },
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "hgnc": "HGNC:59",
        "name": "ATP binding cassette subfamily C member 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcc8"
      },
      {
        "slug": "appl1",
        "symbol": "APPL1",
        "hgnc": "HGNC:24035",
        "name": "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/appl1"
      },
      {
        "slug": "blk",
        "symbol": "BLK",
        "hgnc": "HGNC:1057",
        "name": "BLK proto-oncogene, Src family tyrosine kinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blk"
      },
      {
        "slug": "cel",
        "symbol": "CEL",
        "hgnc": "HGNC:1848",
        "name": "carboxyl ester lipase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cel"
      },
      {
        "slug": "cic",
        "symbol": "CIC",
        "hgnc": "HGNC:14214",
        "name": "capicua transcriptional repressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cic"
      },
      {
        "slug": "clpb",
        "symbol": "CLPB",
        "hgnc": "HGNC:30664",
        "name": "ClpB family mitochondrial disaggregase",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/clpb"
      },
      {
        "slug": "dbh",
        "symbol": "DBH",
        "hgnc": "HGNC:2689",
        "name": "dopamine beta-hydroxylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dbh"
      },
      {
        "slug": "dnajc19",
        "symbol": "DNAJC19",
        "hgnc": "HGNC:30528",
        "name": "DnaJ heat shock protein family (Hsp40) member C19",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajc19"
      },
      {
        "slug": "dot1l",
        "symbol": "DOT1L",
        "hgnc": "HGNC:24948",
        "name": "DOT1 like histone lysine methyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dot1l"
      },
      {
        "slug": "ebp",
        "symbol": "EBP",
        "hgnc": "HGNC:3133",
        "name": "EBP cholestenol delta-isomerase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebp"
      },
      {
        "slug": "fbp1",
        "symbol": "FBP1",
        "hgnc": "HGNC:3606",
        "name": "fructose-bisphosphatase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbp1"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "hgnc": "HGNC:4195",
        "name": "glucokinase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gck"
      },
      {
        "slug": "gfm2",
        "symbol": "GFM2",
        "hgnc": "HGNC:29682",
        "name": "GTP dependent ribosome recycling factor mitochondrial 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfm2"
      },
      {
        "slug": "h19",
        "symbol": "H19",
        "hgnc": "HGNC:4713",
        "name": "H19 imprinted maternally expressed transcript",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h19"
      },
      {
        "slug": "herc1",
        "symbol": "HERC1",
        "hgnc": "HGNC:4867",
        "name": "HECT and RLD domain containing E3 ubiquitin protein ligase family member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/herc1"
      },
      {
        "slug": "htra2",
        "symbol": "HTRA2",
        "hgnc": "HGNC:14348",
        "name": "HtrA serine peptidase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/htra2"
      },
      {
        "slug": "igf2",
        "symbol": "IGF2",
        "hgnc": "HGNC:5466",
        "name": "insulin like growth factor 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/igf2"
      },
      {
        "slug": "ins",
        "symbol": "INS",
        "hgnc": "HGNC:6081",
        "name": "insulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ins"
      },
      {
        "slug": "kcnj11",
        "symbol": "KCNJ11",
        "hgnc": "HGNC:6257",
        "name": "potassium inwardly rectifying channel subfamily J member 11",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj11"
      },
      {
        "slug": "klf11",
        "symbol": "KLF11",
        "hgnc": "HGNC:11811",
        "name": "KLF transcription factor 11",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf11"
      },
      {
        "slug": "myt1l",
        "symbol": "MYT1L",
        "hgnc": "HGNC:7623",
        "name": "myelin transcription factor 1 like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myt1l"
      },
      {
        "slug": "neurod1",
        "symbol": "NEUROD1",
        "hgnc": "HGNC:7762",
        "name": "neuronal differentiation 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neurod1"
      },
      {
        "slug": "pax4",
        "symbol": "PAX4",
        "hgnc": "HGNC:8618",
        "name": "paired box 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax4"
      },
      {
        "slug": "pck1",
        "symbol": "PCK1",
        "hgnc": "HGNC:8724",
        "name": "phosphoenolpyruvate carboxykinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck1"
      },
      {
        "slug": "pck2",
        "symbol": "PCK2",
        "hgnc": "HGNC:8725",
        "name": "phosphoenolpyruvate carboxykinase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pck2"
      },
      {
        "slug": "pdx1",
        "symbol": "PDX1",
        "hgnc": "HGNC:6107",
        "name": "pancreatic and duodenal homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdx1"
      },
      {
        "slug": "pet100",
        "symbol": "PET100",
        "hgnc": "HGNC:40038",
        "name": "PET100 cytochrome c oxidase chaperone",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pet100"
      },
      {
        "slug": "polr1a",
        "symbol": "POLR1A",
        "hgnc": "HGNC:17264",
        "name": "RNA polymerase I subunit A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/polr1a"
      },
      {
        "slug": "wars2",
        "symbol": "WARS2",
        "hgnc": "HGNC:12730",
        "name": "tryptophanyl tRNA synthetase 2, mitochondrial",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wars2"
      },
      {
        "slug": "apc2",
        "symbol": "APC2",
        "hgnc": "HGNC:24036",
        "name": "APC regulator of Wnt signaling pathway 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/apc2"
      },
      {
        "slug": "mtor",
        "symbol": "MTOR",
        "hgnc": "HGNC:3942",
        "name": "mechanistic target of rapamycin kinase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtor"
      },
      {
        "slug": "cdkn1c",
        "symbol": "CDKN1C",
        "hgnc": "HGNC:1786",
        "name": "cyclin dependent kinase inhibitor 1C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1c"
      },
      {
        "slug": "gys2",
        "symbol": "GYS2",
        "hgnc": "HGNC:4707",
        "name": "glycogen synthase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gys2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "hgnc": "HGNC:6294",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq1"
      },
      {
        "slug": "kcnq1ot1",
        "symbol": "KCNQ1OT1",
        "hgnc": "HGNC:6295",
        "name": "KCNQ1 opposite strand/antisense transcript 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnq1ot1"
      },
      {
        "slug": "prkag2",
        "symbol": "PRKAG2",
        "hgnc": "HGNC:9386",
        "name": "protein kinase AMP-activated non-catalytic subunit gamma 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkag2"
      },
      {
        "slug": "prop1",
        "symbol": "PROP1",
        "hgnc": "HGNC:9455",
        "name": "PROP paired-like homeobox 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prop1"
      }
    ]
  }
}