{
  "url": "https://dantelabs.com/traits/lower-limb-undergrowth",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "lower-limb-undergrowth",
    "id": "HP:0009816",
    "name": "Lower limb undergrowth",
    "definition": "Leg shortening because of underdevelopment of one or more bones of the lower extremity.",
    "synonyms": [
      "Underdeveloped lower limb bones",
      "Hypoplasia involving bones of the lower limbs",
      "Hypoplasia of the lower limbs"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "aplasia-hypoplasia-involving-bones-of-the-lower-limbs",
        "name": "Absent/small lower limb bones",
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-involving-bones-of-the-lower-limbs"
      },
      {
        "slug": "limb-undergrowth",
        "name": "Limb undergrowth",
        "url": "https://dantelabs.com/traits/limb-undergrowth"
      }
    ],
    "narrower": [
      {
        "slug": "short-lower-limbs",
        "name": "Short lower limbs",
        "genes": 14,
        "url": "https://dantelabs.com/traits/short-lower-limbs"
      }
    ],
    "genes": [
      {
        "slug": "chuk",
        "symbol": "CHUK",
        "hgnc": "HGNC:1974",
        "name": "component of inhibitor of nuclear factor kappa B kinase complex",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chuk"
      },
      {
        "slug": "shox",
        "symbol": "SHOX",
        "hgnc": "HGNC:10853",
        "name": "SHOX homeobox",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shox"
      },
      {
        "slug": "nog",
        "symbol": "NOG",
        "hgnc": "HGNC:7866",
        "name": "noggin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nog"
      },
      {
        "slug": "papss2",
        "symbol": "PAPSS2",
        "hgnc": "HGNC:8604",
        "name": "3'-phosphoadenosine 5'-phosphosulfate synthase 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/papss2"
      }
    ]
  }
}