{
  "url": "https://dantelabs.com/traits/lisch-nodules",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "lisch-nodules",
    "id": "HP:0009737",
    "name": "Lisch nodules",
    "definition": "The presence of pigmented, oval and dome-shaped raised hamartomatous nevi of the iris..",
    "synonyms": [
      "Iris hamartomas"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      },
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "hamartoma-of-the-eye",
        "name": "Hamartoma of the eye",
        "url": "https://dantelabs.com/traits/hamartoma-of-the-eye"
      },
      {
        "slug": "iris-nodule",
        "name": "Iris nodule",
        "url": "https://dantelabs.com/traits/iris-nodule"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "msh6",
        "symbol": "MSH6",
        "hgnc": "HGNC:7329",
        "name": "mutS homolog 6",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh6"
      },
      {
        "slug": "nf1",
        "symbol": "NF1",
        "hgnc": "HGNC:7765",
        "name": "neurofibromin 1",
        "frequency": "frequent",
        "diseases": 5,
        "url": "https://dantelabs.com/genes/nf1"
      },
      {
        "slug": "nf2",
        "symbol": "NF2",
        "hgnc": "HGNC:7773",
        "name": "NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nf2"
      },
      {
        "slug": "spred1",
        "symbol": "SPRED1",
        "hgnc": "HGNC:20249",
        "name": "sprouty related EVH1 domain containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spred1"
      }
    ]
  }
}