{
  "url": "https://dantelabs.com/traits/ketotic-hypoglycemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "ketotic-hypoglycemia",
    "id": "HP:0012734",
    "name": "Ketotic hypoglycemia",
    "definition": "Low blood glucose is accompanied by elevated levels of ketone bodies in the body.",
    "synonyms": [
      "Ketotic low blood sugar"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "hypoglycemia",
        "name": "Low blood sugar",
        "url": "https://dantelabs.com/traits/hypoglycemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mc2r",
        "symbol": "MC2R",
        "hgnc": "HGNC:6930",
        "name": "melanocortin 2 receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mc2r"
      },
      {
        "slug": "mrap",
        "symbol": "MRAP",
        "hgnc": "HGNC:1304",
        "name": "melanocortin 2 receptor accessory protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrap"
      },
      {
        "slug": "nnt",
        "symbol": "NNT",
        "hgnc": "HGNC:7863",
        "name": "nicotinamide nucleotide transhydrogenase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nnt"
      },
      {
        "slug": "star",
        "symbol": "STAR",
        "hgnc": "HGNC:11359",
        "name": "steroidogenic acute regulatory protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/star"
      },
      {
        "slug": "txnrd2",
        "symbol": "TXNRD2",
        "hgnc": "HGNC:18155",
        "name": "thioredoxin reductase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/txnrd2"
      },
      {
        "slug": "gys2",
        "symbol": "GYS2",
        "hgnc": "HGNC:4707",
        "name": "glycogen synthase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gys2"
      },
      {
        "slug": "mrpl39",
        "symbol": "MRPL39",
        "hgnc": "HGNC:14027",
        "name": "mitochondrial ribosomal protein L39",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrpl39"
      },
      {
        "slug": "acad8",
        "symbol": "ACAD8",
        "hgnc": "HGNC:87",
        "name": "acyl-CoA dehydrogenase family member 8",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acad8"
      },
      {
        "slug": "acads",
        "symbol": "ACADS",
        "hgnc": "HGNC:90",
        "name": "acyl-CoA dehydrogenase short chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acads"
      },
      {
        "slug": "hnf1a",
        "symbol": "HNF1A",
        "hgnc": "HGNC:11621",
        "name": "HNF1 homeobox A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1a"
      },
      {
        "slug": "phkb",
        "symbol": "PHKB",
        "hgnc": "HGNC:8927",
        "name": "phosphorylase kinase regulatory subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phkb"
      },
      {
        "slug": "slc16a1",
        "symbol": "SLC16A1",
        "hgnc": "HGNC:10922",
        "name": "solute carrier family 16 member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc16a1"
      }
    ]
  }
}