{
  "url": "https://dantelabs.com/traits/intracranial-calcification",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "intracranial-calcification",
    "id": "HP:0430048",
    "name": "Intracranial calcification",
    "definition": "Intracranial calcifications refer to calcifications within the brain parenchyma or vasculature. The five major components of the brain comprise the cerebrum, cerebellum, brain stem, pituitary gland, and hypothalamus.",
    "synonyms": [
      "Intracranial calcifications"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "ectopic-calcification",
        "name": "Ectopic calcification",
        "url": "https://dantelabs.com/traits/ectopic-calcification"
      }
    ],
    "narrower": [
      {
        "slug": "cerebral-calcification",
        "name": "Abnormal deposits of calcium in the brain",
        "genes": 113,
        "url": "https://dantelabs.com/traits/cerebral-calcification"
      },
      {
        "slug": "choroid-plexus-calcification",
        "name": "Choroid plexus calcification",
        "genes": 2,
        "url": "https://dantelabs.com/traits/choroid-plexus-calcification"
      },
      {
        "slug": "meningeal-calcification",
        "name": "Meningeal calcification",
        "genes": 1,
        "url": "https://dantelabs.com/traits/meningeal-calcification"
      }
    ],
    "genes": [
      {
        "slug": "col4a2",
        "symbol": "COL4A2",
        "hgnc": "HGNC:2203",
        "name": "collagen type IV alpha 2 chain",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a2"
      },
      {
        "slug": "tinf2",
        "symbol": "TINF2",
        "hgnc": "HGNC:11824",
        "name": "TERF1 interacting nuclear factor 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tinf2"
      }
    ]
  }
}