{
  "url": "https://dantelabs.com/traits/intestinal-atresia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "intestinal-atresia",
    "id": "HP:0011100",
    "name": "Intestinal atresia",
    "definition": "An abnormal closure, or atresia of the tubular structure of the intestine.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-intestine-morphology",
        "name": "Abnormality of the intestine",
        "url": "https://dantelabs.com/traits/abnormal-intestine-morphology"
      },
      {
        "slug": "gastrointestinal-atresia",
        "name": "Gastrointestinal atresia",
        "url": "https://dantelabs.com/traits/gastrointestinal-atresia"
      }
    ],
    "narrower": [
      {
        "slug": "duodenal-atresia",
        "name": "Absence or narrowing of first part of small bowel",
        "genes": 47,
        "url": "https://dantelabs.com/traits/duodenal-atresia"
      },
      {
        "slug": "jejunal-atresia",
        "name": "Jejunal atresia",
        "genes": 10,
        "url": "https://dantelabs.com/traits/jejunal-atresia"
      },
      {
        "slug": "colonic-atresia",
        "name": "Colonic atresia",
        "genes": 4,
        "url": "https://dantelabs.com/traits/colonic-atresia"
      },
      {
        "slug": "ileal-atresia",
        "name": "Ileal atresia",
        "genes": 4,
        "url": "https://dantelabs.com/traits/ileal-atresia"
      },
      {
        "slug": "rectal-atresia",
        "name": "Rectal atresia",
        "genes": 4,
        "url": "https://dantelabs.com/traits/rectal-atresia"
      }
    ],
    "genes": [
      {
        "slug": "clmp",
        "symbol": "CLMP",
        "hgnc": "HGNC:24039",
        "name": "CXADR like cell adhesion molecule",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clmp"
      },
      {
        "slug": "son",
        "symbol": "SON",
        "hgnc": "HGNC:11183",
        "name": "SON DNA and RNA binding protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/son"
      },
      {
        "slug": "itga6",
        "symbol": "ITGA6",
        "hgnc": "HGNC:6142",
        "name": "integrin subunit alpha 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga6"
      },
      {
        "slug": "itgb4",
        "symbol": "ITGB4",
        "hgnc": "HGNC:6158",
        "name": "integrin subunit beta 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itgb4"
      },
      {
        "slug": "pi4ka",
        "symbol": "PI4KA",
        "hgnc": "HGNC:8983",
        "name": "phosphatidylinositol 4-kinase alpha",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pi4ka"
      },
      {
        "slug": "ttc7a",
        "symbol": "TTC7A",
        "hgnc": "HGNC:19750",
        "name": "tetratricopeptide repeat domain 7A",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ttc7a"
      },
      {
        "slug": "znf699",
        "symbol": "ZNF699",
        "hgnc": "HGNC:24750",
        "name": "zinc finger protein 699",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf699"
      },
      {
        "slug": "chrm3",
        "symbol": "CHRM3",
        "hgnc": "HGNC:1952",
        "name": "cholinergic receptor muscarinic 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrm3"
      },
      {
        "slug": "sin3a",
        "symbol": "SIN3A",
        "hgnc": "HGNC:19353",
        "name": "SIN3 transcription regulator family member A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sin3a"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      }
    ]
  }
}