{
  "url": "https://dantelabs.com/traits/increased-exhausted-t-cell-proportion",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "increased-exhausted-t-cell-proportion",
    "id": "HP:0031514",
    "name": "Increased exhausted T cell proportion",
    "definition": "An abnormally elevated proportion of exhausted T cells (Tex) among circulating T cells. T cell exhaustion is a distinct differentiation state that can be distinguished from naive, effector, and memory T cells. Compared to effector (TE) and memory (TMEM) T cells, exhausted T cells (TEX) display impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity). TEX have limited proliferative potential, especially compared to some subsets of TMEM and naive T cells.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-exhausted-t-cell-proportion",
        "name": "Abnormal exhausted T cell proportion",
        "url": "https://dantelabs.com/traits/abnormal-exhausted-t-cell-proportion"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "rhoh",
        "symbol": "RHOH",
        "hgnc": "HGNC:686",
        "name": "ras homolog family member H",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhoh"
      }
    ]
  }
}