{
  "url": "https://dantelabs.com/traits/foot-joint-contracture",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "foot-joint-contracture",
    "id": "HP:0008366",
    "name": "Contractures of the foot joints",
    "label": "Foot joint contracture",
    "definition": "Contractures of one or more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue.",
    "synonyms": [
      "Contractures involving the joints of the feet",
      "Joint contractures involving the joints of the feet"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-foot-morphology",
        "name": "Abnormal feet structure",
        "url": "https://dantelabs.com/traits/abnormal-foot-morphology"
      },
      {
        "slug": "lower-limb-joint-contracture",
        "name": "Lower-limb joint contracture",
        "url": "https://dantelabs.com/traits/lower-limb-joint-contracture"
      }
    ],
    "narrower": [
      {
        "slug": "achilles-tendon-contracture",
        "name": "Shortening of the achilles tendon",
        "genes": 56,
        "url": "https://dantelabs.com/traits/achilles-tendon-contracture"
      },
      {
        "slug": "flexion-contracture-of-toe",
        "name": "Flexion contracture of toe",
        "genes": 17,
        "url": "https://dantelabs.com/traits/flexion-contracture-of-toe"
      },
      {
        "slug": "ankle-contracture",
        "name": "Ankle contracture",
        "genes": 12,
        "url": "https://dantelabs.com/traits/ankle-contracture"
      }
    ],
    "genes": [
      {
        "slug": "ercc4",
        "symbol": "ERCC4",
        "hgnc": "HGNC:3436",
        "name": "ERCC excision repair 4, endonuclease catalytic subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc4"
      },
      {
        "slug": "ercc6",
        "symbol": "ERCC6",
        "hgnc": "HGNC:3438",
        "name": "ERCC excision repair 6, chromatin remodeling factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc6"
      },
      {
        "slug": "ercc8",
        "symbol": "ERCC8",
        "hgnc": "HGNC:3439",
        "name": "ERCC excision repair 8, CSA ubiquitin ligase complex subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ercc8"
      },
      {
        "slug": "mybpc1",
        "symbol": "MYBPC1",
        "hgnc": "HGNC:7549",
        "name": "myosin binding protein C1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mybpc1"
      },
      {
        "slug": "ddhd2",
        "symbol": "DDHD2",
        "hgnc": "HGNC:29106",
        "name": "DDHD domain containing 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ddhd2"
      },
      {
        "slug": "bcas3",
        "symbol": "BCAS3",
        "hgnc": "HGNC:14347",
        "name": "BCAS3 microtubule associated cell migration factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcas3"
      },
      {
        "slug": "brf1",
        "symbol": "BRF1",
        "hgnc": "HGNC:11551",
        "name": "BRF1 general transcription factor IIIB subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brf1"
      },
      {
        "slug": "cav1",
        "symbol": "CAV1",
        "hgnc": "HGNC:1527",
        "name": "caveolin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cav1"
      },
      {
        "slug": "ccn2",
        "symbol": "CCN2",
        "hgnc": "HGNC:2500",
        "name": "cellular communication network factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccn2"
      },
      {
        "slug": "ccr6",
        "symbol": "CCR6",
        "hgnc": "HGNC:1607",
        "name": "C-C motif chemokine receptor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccr6"
      },
      {
        "slug": "col12a1",
        "symbol": "COL12A1",
        "hgnc": "HGNC:2188",
        "name": "collagen type XII alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col12a1"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "hla-drb1",
        "symbol": "HLA-DRB1",
        "hgnc": "HGNC:4948",
        "name": "major histocompatibility complex, class II, DR beta 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hla-drb1"
      },
      {
        "slug": "irf5",
        "symbol": "IRF5",
        "hgnc": "HGNC:6120",
        "name": "interferon regulatory factor 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf5"
      },
      {
        "slug": "kcnk9",
        "symbol": "KCNK9",
        "hgnc": "HGNC:6283",
        "name": "potassium two pore domain channel subfamily K member 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnk9"
      },
      {
        "slug": "kiaa0319l",
        "symbol": "KIAA0319L",
        "hgnc": "HGNC:30071",
        "name": "KIAA0319 like",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0319l"
      },
      {
        "slug": "mmp1",
        "symbol": "MMP1",
        "hgnc": "HGNC:7155",
        "name": "matrix metallopeptidase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp1"
      },
      {
        "slug": "ptrh2",
        "symbol": "PTRH2",
        "hgnc": "HGNC:24265",
        "name": "peptidyl-tRNA hydrolase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptrh2"
      }
    ]
  }
}