{
  "url": "https://dantelabs.com/traits/extractable-nuclear-antigen-positivity",
  "trait": {
    "bundleId": "2026.10.21-777c9289",
    "release": "2026-09-01",
    "slug": "extractable-nuclear-antigen-positivity",
    "id": "HP:0033476",
    "name": "Extractable nuclear antigen positivity",
    "definition": "The presence of autoantibodies in the serum that react against extractable nuclear components that are referred to as extractable because they can be extracted from cell nuclei with saline solution.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "antinuclear-antibody-positivity",
        "name": "Antinuclear antibody positivity",
        "url": "https://dantelabs.com/traits/antinuclear-antibody-positivity"
      }
    ],
    "narrower": [
      {
        "slug": "anti-sm-antibody-positivity",
        "name": "Anti-Sm antibody positivity",
        "genes": 33,
        "url": "https://dantelabs.com/traits/anti-sm-antibody-positivity"
      },
      {
        "slug": "anti-la-ss-b-antibody-positivity",
        "name": "Anti-La/SS-B antibody positivity",
        "genes": 32,
        "url": "https://dantelabs.com/traits/anti-la-ss-b-antibody-positivity"
      },
      {
        "slug": "anti-u1-ribonucleoprotein-antibody-positivity",
        "name": "Anti-U1 ribonucleoprotein antibody positivity",
        "genes": 32,
        "url": "https://dantelabs.com/traits/anti-u1-ribonucleoprotein-antibody-positivity"
      },
      {
        "slug": "anti-ro-ss-a-antibody-positivity",
        "name": "Anti-Ro/SS-A antibody positivity",
        "genes": 1,
        "url": "https://dantelabs.com/traits/anti-ro-ss-a-antibody-positivity"
      }
    ],
    "genes": [
      {
        "slug": "c1qb",
        "symbol": "C1QB",
        "hgnc": "HGNC:1242",
        "name": "complement C1q B chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1qb"
      }
    ]
  }
}