{
  "url": "https://dantelabs.com/traits/erythematous-plaque",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "erythematous-plaque",
    "id": "HP:0025474",
    "name": "Erythematous plaque",
    "definition": "A plaque (a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter) with a red or reddish color often associated with inflammation or irritation.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "skin-plaque",
        "name": "Skin plaque",
        "url": "https://dantelabs.com/traits/skin-plaque"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ap1s3",
        "symbol": "AP1S3",
        "hgnc": "HGNC:18971",
        "name": "adaptor related protein complex 1 subunit sigma 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ap1s3"
      },
      {
        "slug": "il36rn",
        "symbol": "IL36RN",
        "hgnc": "HGNC:15561",
        "name": "interleukin 36 receptor antagonist",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il36rn"
      },
      {
        "slug": "spink5",
        "symbol": "SPINK5",
        "hgnc": "HGNC:15464",
        "name": "serine peptidase inhibitor Kazal type 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink5"
      },
      {
        "slug": "trpm4",
        "symbol": "TRPM4",
        "hgnc": "HGNC:17993",
        "name": "transient receptor potential cation channel subfamily M member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trpm4"
      },
      {
        "slug": "c1r",
        "symbol": "C1R",
        "hgnc": "HGNC:1246",
        "name": "complement C1r",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1r"
      },
      {
        "slug": "c1s",
        "symbol": "C1S",
        "hgnc": "HGNC:1247",
        "name": "complement C1s",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1s"
      },
      {
        "slug": "mefv",
        "symbol": "MEFV",
        "hgnc": "HGNC:6998",
        "name": "MEFV innate immunity regulator, pyrin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mefv"
      },
      {
        "slug": "ptpn6",
        "symbol": "PTPN6",
        "hgnc": "HGNC:9658",
        "name": "protein tyrosine phosphatase non-receptor type 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptpn6"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "ebp",
        "symbol": "EBP",
        "hgnc": "HGNC:3133",
        "name": "EBP cholestenol delta-isomerase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ebp"
      },
      {
        "slug": "gna14",
        "symbol": "GNA14",
        "hgnc": "HGNC:4382",
        "name": "G protein subunit alpha 14",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gna14"
      },
      {
        "slug": "havcr2",
        "symbol": "HAVCR2",
        "hgnc": "HGNC:18437",
        "name": "hepatitis A virus cellular receptor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/havcr2"
      },
      {
        "slug": "krt10",
        "symbol": "KRT10",
        "hgnc": "HGNC:6413",
        "name": "keratin 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt10"
      },
      {
        "slug": "ldha",
        "symbol": "LDHA",
        "hgnc": "HGNC:6535",
        "name": "lactate dehydrogenase A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ldha"
      },
      {
        "slug": "rasa1",
        "symbol": "RASA1",
        "hgnc": "HGNC:9871",
        "name": "RAS p21 protein activator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasa1"
      },
      {
        "slug": "sdhd",
        "symbol": "SDHD",
        "hgnc": "HGNC:10683",
        "name": "succinate dehydrogenase complex subunit D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sdhd"
      },
      {
        "slug": "col2a1",
        "symbol": "COL2A1",
        "hgnc": "HGNC:2200",
        "name": "collagen type II alpha 1 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col2a1"
      },
      {
        "slug": "mpdu1",
        "symbol": "MPDU1",
        "hgnc": "HGNC:7207",
        "name": "mannose-P-dolichol utilization defect 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpdu1"
      },
      {
        "slug": "card14",
        "symbol": "CARD14",
        "hgnc": "HGNC:16446",
        "name": "caspase recruitment domain family member 14",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/card14"
      }
    ]
  }
}