{
  "url": "https://dantelabs.com/traits/elevated-urinary-succinylacetone-level",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "elevated-urinary-succinylacetone-level",
    "id": "HP:6000598",
    "name": "Elevated urinary succinylacetone level",
    "definition": "Presence in the urine of succinylacetone, which is one of the toic block metabolites formed in tyrosinaemia type 1 because of a defect in the final enzyme of the pathway of the degradation of tyrosine, namely fumarylacetoacetase (FAH, EC 3.7.1.2).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-urine-metabolite-level",
        "name": "Abnormal urine metabolite level",
        "url": "https://dantelabs.com/traits/abnormal-urine-metabolite-level"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fah",
        "symbol": "FAH",
        "hgnc": "HGNC:3579",
        "name": "fumarylacetoacetate hydrolase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fah"
      },
      {
        "slug": "hpd",
        "symbol": "HPD",
        "hgnc": "HGNC:5147",
        "name": "4-hydroxyphenylpyruvate dioxygenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpd"
      }
    ]
  }
}