{
  "url": "https://dantelabs.com/traits/elevated-circulating-thyroglobulin-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "elevated-circulating-thyroglobulin-concentration",
    "id": "HP:0025484",
    "name": "Elevated circulating thyroglobulin concentration",
    "definition": "The concentration of thyroglobulin in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Elevated thyroglobulin concentration",
      "Elevated thyroglobulin level",
      "Elevated thyroglobulin level in blood",
      "Increased circulating thyroglobulin level",
      "Increased thyroglobulin concentration",
      "Increased thyroglobulin level",
      "Increased thyroglobulin level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-thyroglobulin-concentration",
        "name": "Abnormal circulating thyroglobulin concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-thyroglobulin-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "glis3",
        "symbol": "GLIS3",
        "hgnc": "HGNC:28510",
        "name": "GLIS family zinc finger 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glis3"
      },
      {
        "slug": "thrb",
        "symbol": "THRB",
        "hgnc": "HGNC:11799",
        "name": "thyroid hormone receptor beta",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/thrb"
      },
      {
        "slug": "tshr",
        "symbol": "TSHR",
        "hgnc": "HGNC:12373",
        "name": "thyroid stimulating hormone receptor",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tshr"
      },
      {
        "slug": "duox2",
        "symbol": "DUOX2",
        "hgnc": "HGNC:13273",
        "name": "dual oxidase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/duox2"
      },
      {
        "slug": "foxi1",
        "symbol": "FOXI1",
        "hgnc": "HGNC:3815",
        "name": "forkhead box I1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/foxi1"
      },
      {
        "slug": "kcnj10",
        "symbol": "KCNJ10",
        "hgnc": "HGNC:6256",
        "name": "potassium inwardly rectifying channel subfamily J member 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj10"
      },
      {
        "slug": "pax8",
        "symbol": "PAX8",
        "hgnc": "HGNC:8622",
        "name": "paired box 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax8"
      },
      {
        "slug": "slc26a4",
        "symbol": "SLC26A4",
        "hgnc": "HGNC:8818",
        "name": "solute carrier family 26 member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a4"
      },
      {
        "slug": "slc35a2",
        "symbol": "SLC35A2",
        "hgnc": "HGNC:11022",
        "name": "solute carrier family 35 member A2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc35a2"
      }
    ]
  }
}