{
  "url": "https://dantelabs.com/traits/elevated-circulating-scd25-concentration",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "elevated-circulating-scd25-concentration",
    "id": "HP:0033833",
    "name": "Elevated circulating sCD25 concentration",
    "definition": "The concentration of sCD25 (= soluble CD25, = soluble interleukin-2 receptor alpha-chain, = soluble IL-2 receptor alpha) in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Elevated circulating interleukin-2 receptor alpha-chain"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-protein-concentration",
        "name": "Blood protein disease",
        "url": "https://dantelabs.com/traits/abnormal-circulating-protein-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "ak2",
        "symbol": "AK2",
        "hgnc": "HGNC:362",
        "name": "adenylate kinase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ak2"
      },
      {
        "slug": "psmb9",
        "symbol": "PSMB9",
        "hgnc": "HGNC:9546",
        "name": "proteasome 20S subunit beta 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psmb9"
      },
      {
        "slug": "rc3h1",
        "symbol": "RC3H1",
        "hgnc": "HGNC:29434",
        "name": "ring finger and CCCH-type domains 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rc3h1"
      }
    ]
  }
}