{
  "url": "https://dantelabs.com/traits/elevated-circulating-iron-concentration",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "elevated-circulating-iron-concentration",
    "id": "HP:0003452",
    "name": "Elevated circulating iron concentration",
    "definition": "The concentration of iron cation in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Elevated iron cation concentration",
      "Elevated iron cation level",
      "Elevated iron cation level in blood",
      "Increased circulating iron concentration",
      "Increased iron cation concentration",
      "Increased iron cation level",
      "Increased iron cation level in blood",
      "Increased serum iron"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-iron-concentration",
        "name": "Abnormal circulating iron concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-iron-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "fth1",
        "symbol": "FTH1",
        "hgnc": "HGNC:3976",
        "name": "ferritin heavy chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fth1"
      },
      {
        "slug": "hjv",
        "symbol": "HJV",
        "hgnc": "HGNC:4887",
        "name": "hemojuvelin BMP co-receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hjv"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "slc11a2",
        "symbol": "SLC11A2",
        "hgnc": "HGNC:10908",
        "name": "solute carrier family 11 member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc11a2"
      },
      {
        "slug": "kif23",
        "symbol": "KIF23",
        "hgnc": "HGNC:6392",
        "name": "kinesin family member 23",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif23"
      },
      {
        "slug": "pklr",
        "symbol": "PKLR",
        "hgnc": "HGNC:9020",
        "name": "pyruvate kinase L/R",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pklr"
      },
      {
        "slug": "racgap1",
        "symbol": "RACGAP1",
        "hgnc": "HGNC:9804",
        "name": "Rac GTPase activating protein 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/racgap1"
      },
      {
        "slug": "steap3",
        "symbol": "STEAP3",
        "hgnc": "HGNC:24592",
        "name": "STEAP3 metalloreductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/steap3"
      },
      {
        "slug": "tfr2",
        "symbol": "TFR2",
        "hgnc": "HGNC:11762",
        "name": "transferrin receptor 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tfr2"
      },
      {
        "slug": "bcs1l",
        "symbol": "BCS1L",
        "hgnc": "HGNC:1020",
        "name": "BCS1 ubiquinol-cytochrome c reductase complex chaperone",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcs1l"
      },
      {
        "slug": "bmp2",
        "symbol": "BMP2",
        "hgnc": "HGNC:1069",
        "name": "bone morphogenetic protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmp2"
      },
      {
        "slug": "hamp",
        "symbol": "HAMP",
        "hgnc": "HGNC:15598",
        "name": "hepcidin antimicrobial peptide",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hamp"
      },
      {
        "slug": "hfe",
        "symbol": "HFE",
        "hgnc": "HGNC:4886",
        "name": "homeostatic iron regulator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hfe"
      },
      {
        "slug": "skic3",
        "symbol": "SKIC3",
        "hgnc": "HGNC:23639",
        "name": "SKI3 subunit of superkiller complex",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/skic3"
      }
    ]
  }
}