{
  "url": "https://dantelabs.com/traits/elevated-circulating-creatinine-concentration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "elevated-circulating-creatinine-concentration",
    "id": "HP:0003259",
    "name": "Elevated creatinine",
    "label": "Elevated circulating creatinine concentration",
    "definition": "An increased amount of creatinine in the blood.",
    "synonyms": [
      "High blood creatinine level",
      "Increased creatinine",
      "Increased serum creatinine",
      "Elevated serum creatinine"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-creatinine-concentration",
        "name": "Abnormal blood creatinine level",
        "url": "https://dantelabs.com/traits/abnormal-circulating-creatinine-concentration"
      },
      {
        "slug": "azotemia",
        "name": "Azotemia",
        "url": "https://dantelabs.com/traits/azotemia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "alg8",
        "symbol": "ALG8",
        "hgnc": "HGNC:23161",
        "name": "ALG8 alpha-1,3-glucosyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg8"
      },
      {
        "slug": "aprt",
        "symbol": "APRT",
        "hgnc": "HGNC:626",
        "name": "adenine phosphoribosyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aprt"
      },
      {
        "slug": "c1galt1c1",
        "symbol": "C1GALT1C1",
        "hgnc": "HGNC:24338",
        "name": "C1GALT1 specific chaperone 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c1galt1c1"
      },
      {
        "slug": "cc2d2a",
        "symbol": "CC2D2A",
        "hgnc": "HGNC:29253",
        "name": "coiled-coil and C2 domain containing 2A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cc2d2a"
      },
      {
        "slug": "cldn16",
        "symbol": "CLDN16",
        "hgnc": "HGNC:2037",
        "name": "claudin 16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cldn16"
      },
      {
        "slug": "cpt2",
        "symbol": "CPT2",
        "hgnc": "HGNC:2330",
        "name": "carnitine palmitoyltransferase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cpt2"
      },
      {
        "slug": "eefsec",
        "symbol": "EEFSEC",
        "hgnc": "HGNC:24614",
        "name": "eukaryotic elongation factor, selenocysteine-tRNA specific",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eefsec"
      },
      {
        "slug": "hoxa13",
        "symbol": "HOXA13",
        "hgnc": "HGNC:5102",
        "name": "homeobox A13",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxa13"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "mlip",
        "symbol": "MLIP",
        "hgnc": "HGNC:21355",
        "name": "muscular LMNA interacting protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlip"
      },
      {
        "slug": "pax2",
        "symbol": "PAX2",
        "hgnc": "HGNC:8616",
        "name": "paired box 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax2"
      },
      {
        "slug": "pld4",
        "symbol": "PLD4",
        "hgnc": "HGNC:23792",
        "name": "phospholipase D family member 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pld4"
      },
      {
        "slug": "pskh1",
        "symbol": "PSKH1",
        "hgnc": "HGNC:9529",
        "name": "protein serine kinase H1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pskh1"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "hgnc": "HGNC:18276",
        "name": "SEC61 translocon subunit alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec61a1"
      },
      {
        "slug": "slc41a1",
        "symbol": "SLC41A1",
        "hgnc": "HGNC:19429",
        "name": "solute carrier family 41 member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc41a1"
      },
      {
        "slug": "slc4a2",
        "symbol": "SLC4A2",
        "hgnc": "HGNC:11028",
        "name": "solute carrier family 4 member 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a2"
      },
      {
        "slug": "tmem260",
        "symbol": "TMEM260",
        "hgnc": "HGNC:20185",
        "name": "transmembrane protein 260",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem260"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "alg5",
        "symbol": "ALG5",
        "hgnc": "HGNC:20266",
        "name": "ALG5 dolichyl-phosphate beta-glucosyltransferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg5"
      },
      {
        "slug": "alg9",
        "symbol": "ALG9",
        "hgnc": "HGNC:15672",
        "name": "ALG9 alpha-1,2-mannosyltransferase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg9"
      },
      {
        "slug": "bicc1",
        "symbol": "BICC1",
        "hgnc": "HGNC:19351",
        "name": "BicC family RNA binding protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bicc1"
      },
      {
        "slug": "dnajb11",
        "symbol": "DNAJB11",
        "hgnc": "HGNC:14889",
        "name": "DnaJ heat shock protein family (Hsp40) member B11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb11"
      },
      {
        "slug": "ganab",
        "symbol": "GANAB",
        "hgnc": "HGNC:4138",
        "name": "glucosidase II alpha subunit",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ganab"
      },
      {
        "slug": "nek8",
        "symbol": "NEK8",
        "hgnc": "HGNC:13387",
        "name": "NIMA related kinase 8",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nek8"
      },
      {
        "slug": "pkd1",
        "symbol": "PKD1",
        "hgnc": "HGNC:9008",
        "name": "polycystin 1, transient receptor potential channel interacting",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pkd1"
      },
      {
        "slug": "pkd2",
        "symbol": "PKD2",
        "hgnc": "HGNC:9009",
        "name": "polycystin 2, transient receptor potential cation channel",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pkd2"
      },
      {
        "slug": "umod",
        "symbol": "UMOD",
        "hgnc": "HGNC:12559",
        "name": "uromodulin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/umod"
      },
      {
        "slug": "ccnd1",
        "symbol": "CCND1",
        "hgnc": "HGNC:1582",
        "name": "cyclin D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnd1"
      },
      {
        "slug": "dbh",
        "symbol": "DBH",
        "hgnc": "HGNC:2689",
        "name": "dopamine beta-hydroxylase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dbh"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "hgnc": "HGNC:11630",
        "name": "HNF1 homeobox B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1b"
      },
      {
        "slug": "ift56",
        "symbol": "IFT56",
        "hgnc": "HGNC:21882",
        "name": "intraflagellar transport 56",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift56"
      },
      {
        "slug": "mrps7",
        "symbol": "MRPS7",
        "hgnc": "HGNC:14499",
        "name": "mitochondrial ribosomal protein S7",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps7"
      },
      {
        "slug": "slc22a12",
        "symbol": "SLC22A12",
        "hgnc": "HGNC:17989",
        "name": "solute carrier family 22 member 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc22a12"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "ctns",
        "symbol": "CTNS",
        "hgnc": "HGNC:2518",
        "name": "cystinosin, lysosomal cystine transporter",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctns"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "hprt1",
        "symbol": "HPRT1",
        "hgnc": "HGNC:5157",
        "name": "hypoxanthine phosphoribosyltransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hprt1"
      },
      {
        "slug": "nphp1",
        "symbol": "NPHP1",
        "hgnc": "HGNC:7905",
        "name": "nephrocystin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nphp1"
      },
      {
        "slug": "slc4a1",
        "symbol": "SLC4A1",
        "hgnc": "HGNC:11027",
        "name": "solute carrier family 4 member 1 (Diego blood group)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc4a1"
      },
      {
        "slug": "corin",
        "symbol": "CORIN",
        "hgnc": "HGNC:19012",
        "name": "corin, serine peptidase",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/corin"
      },
      {
        "slug": "flt1",
        "symbol": "FLT1",
        "hgnc": "HGNC:3763",
        "name": "fms related receptor tyrosine kinase 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flt1"
      },
      {
        "slug": "stox1",
        "symbol": "STOX1",
        "hgnc": "HGNC:23508",
        "name": "storkhead box 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stox1"
      },
      {
        "slug": "adamts13",
        "symbol": "ADAMTS13",
        "hgnc": "HGNC:1366",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts13"
      },
      {
        "slug": "c3",
        "symbol": "C3",
        "hgnc": "HGNC:1318",
        "name": "complement C3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/c3"
      },
      {
        "slug": "cd46",
        "symbol": "CD46",
        "hgnc": "HGNC:6953",
        "name": "CD46 molecule",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd46"
      },
      {
        "slug": "cfb",
        "symbol": "CFB",
        "hgnc": "HGNC:1037",
        "name": "complement factor B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfb"
      },
      {
        "slug": "cfh",
        "symbol": "CFH",
        "hgnc": "HGNC:4883",
        "name": "complement factor H",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfh"
      },
      {
        "slug": "cfhr1",
        "symbol": "CFHR1",
        "hgnc": "HGNC:4888",
        "name": "complement factor H related 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfhr1"
      },
      {
        "slug": "cfhr3",
        "symbol": "CFHR3",
        "hgnc": "HGNC:16980",
        "name": "complement factor H related 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfhr3"
      },
      {
        "slug": "cfi",
        "symbol": "CFI",
        "hgnc": "HGNC:5394",
        "name": "complement factor I",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfi"
      },
      {
        "slug": "coq7",
        "symbol": "COQ7",
        "hgnc": "HGNC:2244",
        "name": "coenzyme Q7, hydroxylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/coq7"
      },
      {
        "slug": "elp1",
        "symbol": "ELP1",
        "hgnc": "HGNC:5959",
        "name": "elongator acetyltransferase complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elp1"
      },
      {
        "slug": "fan1",
        "symbol": "FAN1",
        "hgnc": "HGNC:29170",
        "name": "FANCD2 and FANCI associated nuclease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fan1"
      },
      {
        "slug": "invs",
        "symbol": "INVS",
        "hgnc": "HGNC:17870",
        "name": "inversin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/invs"
      },
      {
        "slug": "muc1",
        "symbol": "MUC1",
        "hgnc": "HGNC:7508",
        "name": "mucin 1, cell surface associated",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/muc1"
      },
      {
        "slug": "thbd",
        "symbol": "THBD",
        "hgnc": "HGNC:11784",
        "name": "thrombomodulin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/thbd"
      }
    ]
  }
}