{
  "url": "https://dantelabs.com/traits/dicarboxylic-acidemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "dicarboxylic-acidemia",
    "id": "HP:0040145",
    "name": "Dicarboxylic acidemia",
    "definition": "The concentration of dicarboxylic acid in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Elevated dicarboxylic acid concentration",
      "Elevated dicarboxylic acid level",
      "Elevated dicarboxylic acid level in blood",
      "Increased dicarboxylic acid concentration",
      "Increased dicarboxylic acid level",
      "Increased dicarboxylic acid level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-dicarboxylic-acid-concentration",
        "name": "Abnormal circulating dicarboxylic acid concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-dicarboxylic-acid-concentration"
      },
      {
        "slug": "acidemia",
        "name": "Acidemia",
        "url": "https://dantelabs.com/traits/acidemia"
      }
    ],
    "narrower": [
      {
        "slug": "methylmalonic-acidemia",
        "name": "Methylmalonic acidemia",
        "genes": 15,
        "url": "https://dantelabs.com/traits/methylmalonic-acidemia"
      },
      {
        "slug": "d-2-hydroxyglutaric-acidemia",
        "name": "D-2-hydroxyglutaric acidemia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/d-2-hydroxyglutaric-acidemia"
      },
      {
        "slug": "l-2-hydroxyglutaric-acidemia",
        "name": "L-2-hydroxyglutaric acidemia",
        "genes": 1,
        "url": "https://dantelabs.com/traits/l-2-hydroxyglutaric-acidemia"
      }
    ],
    "genes": [
      {
        "slug": "acsf3",
        "symbol": "ACSF3",
        "hgnc": "HGNC:27288",
        "name": "acyl-CoA synthetase family member 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acsf3"
      }
    ]
  }
}