{
  "url": "https://dantelabs.com/traits/diaphragmatic-weakness",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "diaphragmatic-weakness",
    "id": "HP:0009113",
    "name": "Weak diaphragm",
    "label": "Diaphragmatic weakness",
    "definition": "A decrease in the strength of the diaphragm.",
    "synonyms": [
      "Diaphragmatic paraparesis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      }
    ],
    "narrower": [
      {
        "slug": "diaphragmatic-paralysis",
        "name": "Diaphragmatic paralysis",
        "genes": 7,
        "url": "https://dantelabs.com/traits/diaphragmatic-paralysis"
      }
    ],
    "genes": [
      {
        "slug": "dnajb4",
        "symbol": "DNAJB4",
        "hgnc": "HGNC:14886",
        "name": "DnaJ heat shock protein family (Hsp40) member B4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnajb4"
      },
      {
        "slug": "chrna1",
        "symbol": "CHRNA1",
        "hgnc": "HGNC:1955",
        "name": "cholinergic receptor nicotinic alpha 1 subunit",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chrna1"
      },
      {
        "slug": "col12a1",
        "symbol": "COL12A1",
        "hgnc": "HGNC:2188",
        "name": "collagen type XII alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col12a1"
      },
      {
        "slug": "col6a1",
        "symbol": "COL6A1",
        "hgnc": "HGNC:2211",
        "name": "collagen type VI alpha 1 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col6a1"
      },
      {
        "slug": "col6a2",
        "symbol": "COL6A2",
        "hgnc": "HGNC:2212",
        "name": "collagen type VI alpha 2 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col6a2"
      },
      {
        "slug": "col6a3",
        "symbol": "COL6A3",
        "hgnc": "HGNC:2213",
        "name": "collagen type VI alpha 3 chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col6a3"
      },
      {
        "slug": "rfc4",
        "symbol": "RFC4",
        "hgnc": "HGNC:9972",
        "name": "replication factor C subunit 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfc4"
      },
      {
        "slug": "pmp22",
        "symbol": "PMP22",
        "hgnc": "HGNC:9118",
        "name": "peripheral myelin protein 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pmp22"
      },
      {
        "slug": "ighmbp2",
        "symbol": "IGHMBP2",
        "hgnc": "HGNC:5542",
        "name": "immunoglobulin mu DNA binding protein 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ighmbp2"
      },
      {
        "slug": "megf10",
        "symbol": "MEGF10",
        "hgnc": "HGNC:29634",
        "name": "multiple EGF like domains 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/megf10"
      },
      {
        "slug": "slc52a3",
        "symbol": "SLC52A3",
        "hgnc": "HGNC:16187",
        "name": "solute carrier family 52 member 3",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc52a3"
      },
      {
        "slug": "trpv4",
        "symbol": "TRPV4",
        "hgnc": "HGNC:18083",
        "name": "transient receptor potential cation channel subfamily V member 4",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/trpv4"
      },
      {
        "slug": "ttn",
        "symbol": "TTN",
        "hgnc": "HGNC:12403",
        "name": "titin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttn"
      }
    ]
  }
}