{
  "url": "https://dantelabs.com/traits/defective-b-cell-activation",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "defective-b-cell-activation",
    "id": "HP:0005384",
    "name": "Defective B cell activation",
    "definition": "A reduced ability of a B cell to become activated, i.e., the change in morphology and behavior of",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-b-cell-physiology",
        "name": "Abnormality of B cell physiology",
        "url": "https://dantelabs.com/traits/abnormal-b-cell-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "defective-b-cell-differentiation",
        "name": "Defective B cell differentiation",
        "genes": 2,
        "url": "https://dantelabs.com/traits/defective-b-cell-differentiation"
      }
    ],
    "genes": [
      {
        "slug": "casp8",
        "symbol": "CASP8",
        "hgnc": "HGNC:1509",
        "name": "caspase 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/casp8"
      }
    ]
  }
}