{
  "url": "https://dantelabs.com/traits/cystathioninemia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "cystathioninemia",
    "id": "HP:0003286",
    "name": "High blood cystathionine levels",
    "label": "Cystathioninemia",
    "definition": "The concentration of cystathionine in the blood circulation is above the upper limit of normal.",
    "synonyms": [
      "Elevated cystathionine concentration",
      "Elevated cystathionine level",
      "Elevated cystathionine level in blood",
      "Increased cystathionine concentration",
      "Increased cystathionine level",
      "Increased cystathionine level in blood"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-proteinogenic-amino-acid-derivative-concentration",
        "name": "Abnormal circulating proteinogenic amino acid derivative concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-proteinogenic-amino-acid-derivative-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mthfr",
        "symbol": "MTHFR",
        "hgnc": "HGNC:7436",
        "name": "methylenetetrahydrofolate reductase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfr"
      },
      {
        "slug": "cth",
        "symbol": "CTH",
        "hgnc": "HGNC:2501",
        "name": "cystathionine gamma-lyase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cth"
      },
      {
        "slug": "lmbrd1",
        "symbol": "LMBRD1",
        "hgnc": "HGNC:23038",
        "name": "LMBR1 domain containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmbrd1"
      },
      {
        "slug": "mmachc",
        "symbol": "MMACHC",
        "hgnc": "HGNC:24525",
        "name": "metabolism of cobalamin associated C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmachc"
      },
      {
        "slug": "prdx1",
        "symbol": "PRDX1",
        "hgnc": "HGNC:9352",
        "name": "peroxiredoxin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdx1"
      }
    ]
  }
}