{
  "url": "https://dantelabs.com/traits/ciliary-dyskinesia",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "ciliary-dyskinesia",
    "id": "HP:0012265",
    "name": "Ciliary dyskinesia",
    "definition": "A deviation from the normally well coordinated pattern of intracellular and intercellular synchrony of motile cilia. Dyskinetic cilia usually beat out of synchrony relative to neighboring cilia.",
    "synonyms": [
      "Lack of coordinated beating of respiratory cilia"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-ciliary-motility",
        "name": "Abnormal ciliary motility",
        "url": "https://dantelabs.com/traits/abnormal-ciliary-motility"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cfap74",
        "symbol": "CFAP74",
        "hgnc": "HGNC:29368",
        "name": "cilia and flagella associated protein 74",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap74"
      },
      {
        "slug": "dnah11",
        "symbol": "DNAH11",
        "hgnc": "HGNC:2942",
        "name": "dynein axonemal heavy chain 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah11"
      },
      {
        "slug": "hydin",
        "symbol": "HYDIN",
        "hgnc": "HGNC:19368",
        "name": "HYDIN axonemal central pair apparatus protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hydin"
      },
      {
        "slug": "odad3",
        "symbol": "ODAD3",
        "hgnc": "HGNC:28303",
        "name": "outer dynein arm docking complex subunit 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad3"
      },
      {
        "slug": "stk36",
        "symbol": "STK36",
        "hgnc": "HGNC:17209",
        "name": "serine/threonine kinase 36",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk36"
      },
      {
        "slug": "ccdc39",
        "symbol": "CCDC39",
        "hgnc": "HGNC:25244",
        "name": "coiled-coil domain 39 molecular ruler complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc39"
      },
      {
        "slug": "ccdc40",
        "symbol": "CCDC40",
        "hgnc": "HGNC:26090",
        "name": "coiled-coil domain 40 molecular ruler complex subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc40"
      },
      {
        "slug": "ccno",
        "symbol": "CCNO",
        "hgnc": "HGNC:18576",
        "name": "cyclin O",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccno"
      },
      {
        "slug": "cfap298",
        "symbol": "CFAP298",
        "hgnc": "HGNC:1301",
        "name": "cilia and flagella associated protein 298",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap298"
      },
      {
        "slug": "dnaaf1",
        "symbol": "DNAAF1",
        "hgnc": "HGNC:30539",
        "name": "dynein axonemal assembly factor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf1"
      },
      {
        "slug": "dnaaf11",
        "symbol": "DNAAF11",
        "hgnc": "HGNC:16725",
        "name": "dynein axonemal assembly factor 11",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf11"
      },
      {
        "slug": "dnaaf19",
        "symbol": "DNAAF19",
        "hgnc": "HGNC:32700",
        "name": "dynein axonemal assembly factor 19",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf19"
      },
      {
        "slug": "dnaaf2",
        "symbol": "DNAAF2",
        "hgnc": "HGNC:20188",
        "name": "dynein axonemal assembly factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf2"
      },
      {
        "slug": "dnaaf3",
        "symbol": "DNAAF3",
        "hgnc": "HGNC:30492",
        "name": "dynein axonemal assembly factor 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf3"
      },
      {
        "slug": "dnaaf4",
        "symbol": "DNAAF4",
        "hgnc": "HGNC:21493",
        "name": "dynein axonemal assembly factor 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf4"
      },
      {
        "slug": "dnaaf5",
        "symbol": "DNAAF5",
        "hgnc": "HGNC:26013",
        "name": "dynein axonemal assembly factor 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnaaf5"
      },
      {
        "slug": "dnah5",
        "symbol": "DNAH5",
        "hgnc": "HGNC:2950",
        "name": "dynein axonemal heavy chain 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah5"
      },
      {
        "slug": "dnai1",
        "symbol": "DNAI1",
        "hgnc": "HGNC:2954",
        "name": "dynein axonemal intermediate chain 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnai1"
      },
      {
        "slug": "dnai2",
        "symbol": "DNAI2",
        "hgnc": "HGNC:18744",
        "name": "dynein axonemal intermediate chain 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnai2"
      },
      {
        "slug": "dnal1",
        "symbol": "DNAL1",
        "hgnc": "HGNC:23247",
        "name": "dynein axonemal light chain 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnal1"
      },
      {
        "slug": "drc1",
        "symbol": "DRC1",
        "hgnc": "HGNC:24245",
        "name": "dynein regulatory complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc1"
      },
      {
        "slug": "drc2",
        "symbol": "DRC2",
        "hgnc": "HGNC:29937",
        "name": "dynein regulatory complex subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc2"
      },
      {
        "slug": "drc4",
        "symbol": "DRC4",
        "hgnc": "HGNC:4166",
        "name": "dynein regulatory complex subunit 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drc4"
      },
      {
        "slug": "nme8",
        "symbol": "NME8",
        "hgnc": "HGNC:16473",
        "name": "NME/NM23 family member 8",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nme8"
      },
      {
        "slug": "odad1",
        "symbol": "ODAD1",
        "hgnc": "HGNC:26560",
        "name": "outer dynein arm docking complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad1"
      },
      {
        "slug": "odad2",
        "symbol": "ODAD2",
        "hgnc": "HGNC:25583",
        "name": "outer dynein arm docking complex subunit 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/odad2"
      },
      {
        "slug": "rsph1",
        "symbol": "RSPH1",
        "hgnc": "HGNC:12371",
        "name": "radial spoke head component 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph1"
      },
      {
        "slug": "rsph3",
        "symbol": "RSPH3",
        "hgnc": "HGNC:21054",
        "name": "radial spoke head 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph3"
      },
      {
        "slug": "rsph4a",
        "symbol": "RSPH4A",
        "hgnc": "HGNC:21558",
        "name": "radial spoke head component 4A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph4a"
      },
      {
        "slug": "rsph9",
        "symbol": "RSPH9",
        "hgnc": "HGNC:21057",
        "name": "radial spoke head component 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rsph9"
      },
      {
        "slug": "spag1",
        "symbol": "SPAG1",
        "hgnc": "HGNC:11212",
        "name": "sperm associated antigen 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spag1"
      },
      {
        "slug": "zmynd10",
        "symbol": "ZMYND10",
        "hgnc": "HGNC:19412",
        "name": "zinc finger MYND-type containing 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zmynd10"
      }
    ]
  }
}