{
  "url": "https://dantelabs.com/traits/cardiomyocyte-hypertrophy",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "cardiomyocyte-hypertrophy",
    "id": "HP:0031319",
    "name": "Cardiomyocyte hypertrophy",
    "definition": "An increase in cell size, enhanced protein synthesis, and heightened organization of the sarcomere within cardiac myocytes.",
    "synonyms": [
      "Myocyte cellular hypertrophy"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cardiomyocyte-morphology",
        "name": "Abnormal cardiomyocyte morphology",
        "url": "https://dantelabs.com/traits/abnormal-cardiomyocyte-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "actc1",
        "symbol": "ACTC1",
        "hgnc": "HGNC:143",
        "name": "actin alpha cardiac muscle 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actc1"
      },
      {
        "slug": "actn2",
        "symbol": "ACTN2",
        "hgnc": "HGNC:164",
        "name": "actinin alpha 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actn2"
      },
      {
        "slug": "alpk3",
        "symbol": "ALPK3",
        "hgnc": "HGNC:17574",
        "name": "alpha kinase 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alpk3"
      },
      {
        "slug": "emd",
        "symbol": "EMD",
        "hgnc": "HGNC:3331",
        "name": "emerin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/emd"
      },
      {
        "slug": "gyg1",
        "symbol": "GYG1",
        "hgnc": "HGNC:4699",
        "name": "glycogenin 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gyg1"
      },
      {
        "slug": "gys1",
        "symbol": "GYS1",
        "hgnc": "HGNC:4706",
        "name": "glycogen synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gys1"
      },
      {
        "slug": "klhl24",
        "symbol": "KLHL24",
        "hgnc": "HGNC:25947",
        "name": "kelch like family member 24",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klhl24"
      },
      {
        "slug": "tnni3",
        "symbol": "TNNI3",
        "hgnc": "HGNC:11947",
        "name": "troponin I3, cardiac type",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnni3"
      },
      {
        "slug": "vcl",
        "symbol": "VCL",
        "hgnc": "HGNC:12665",
        "name": "vinculin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vcl"
      },
      {
        "slug": "dolk",
        "symbol": "DOLK",
        "hgnc": "HGNC:23406",
        "name": "dolichol kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dolk"
      },
      {
        "slug": "dsp",
        "symbol": "DSP",
        "hgnc": "HGNC:3052",
        "name": "desmoplakin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dsp"
      }
    ]
  }
}