{
  "url": "https://dantelabs.com/traits/bone-marrow-maturation-arrest",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "bone-marrow-maturation-arrest",
    "id": "HP:0033606",
    "name": "Bone marrow maturation arrest",
    "definition": "Interruption of the procecss of diffferentiation of hematopoietic cells in the bone marrow, manifested by an increased proportion of immature cells in the bone marrow.",
    "synonyms": [
      "Haematopoietic maturation arrest",
      "Hematopoietic maturation arrest"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-bone-marrow-cell-morphology",
        "name": "Bone marrow disease",
        "url": "https://dantelabs.com/traits/abnormal-bone-marrow-cell-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "bone-marrow-arrest-at-the-promyelocytic-stage",
        "name": "Bone marrow arrest at the promyelocytic stage",
        "genes": 3,
        "url": "https://dantelabs.com/traits/bone-marrow-arrest-at-the-promyelocytic-stage"
      },
      {
        "slug": "myeloid-maturation-arrest",
        "name": "Myeloid maturation arrest",
        "genes": 1,
        "url": "https://dantelabs.com/traits/myeloid-maturation-arrest"
      }
    ],
    "genes": [
      {
        "slug": "clpb",
        "symbol": "CLPB",
        "hgnc": "HGNC:30664",
        "name": "ClpB family mitochondrial disaggregase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clpb"
      },
      {
        "slug": "flna",
        "symbol": "FLNA",
        "hgnc": "HGNC:3754",
        "name": "filamin A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flna"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "hgnc": "HGNC:18276",
        "name": "SEC61 translocon subunit alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sec61a1"
      },
      {
        "slug": "smarcd2",
        "symbol": "SMARCD2",
        "hgnc": "HGNC:11107",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit D2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcd2"
      },
      {
        "slug": "was",
        "symbol": "WAS",
        "hgnc": "HGNC:12731",
        "name": "WASP actin nucleation promoting factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/was"
      },
      {
        "slug": "jagn1",
        "symbol": "JAGN1",
        "hgnc": "HGNC:26926",
        "name": "jagunal vesicle mediated transporter 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jagn1"
      }
    ]
  }
}