{
  "url": "https://dantelabs.com/traits/anisocytosis",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "anisocytosis",
    "id": "HP:0011273",
    "name": "Unequal size of red blood cells",
    "label": "Anisocytosis",
    "definition": "Abnormally increased variability in the size of erythrocytes.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-erythrocyte-morphology",
        "name": "Abnormal erythrocyte morphology",
        "url": "https://dantelabs.com/traits/abnormal-erythrocyte-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "abcb7",
        "symbol": "ABCB7",
        "hgnc": "HGNC:48",
        "name": "ATP binding cassette subfamily B member 7",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcb7"
      },
      {
        "slug": "atpaf2",
        "symbol": "ATPAF2",
        "hgnc": "HGNC:18802",
        "name": "ATP synthase mitochondrial F1 complex assembly factor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atpaf2"
      },
      {
        "slug": "dock11",
        "symbol": "DOCK11",
        "hgnc": "HGNC:23483",
        "name": "dedicator of cytokinesis 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dock11"
      },
      {
        "slug": "flt3lg",
        "symbol": "FLT3LG",
        "hgnc": "HGNC:3766",
        "name": "fms related receptor tyrosine kinase 3 ligand",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flt3lg"
      },
      {
        "slug": "gata1",
        "symbol": "GATA1",
        "hgnc": "HGNC:4170",
        "name": "GATA binding protein 1",
        "frequency": "obligate",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/gata1"
      },
      {
        "slug": "klf1",
        "symbol": "KLF1",
        "hgnc": "HGNC:6345",
        "name": "KLF transcription factor 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/klf1"
      },
      {
        "slug": "kif23",
        "symbol": "KIF23",
        "hgnc": "HGNC:6392",
        "name": "kinesin family member 23",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif23"
      },
      {
        "slug": "racgap1",
        "symbol": "RACGAP1",
        "hgnc": "HGNC:9804",
        "name": "Rac GTPase activating protein 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/racgap1"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "trnt1",
        "symbol": "TRNT1",
        "hgnc": "HGNC:17341",
        "name": "tRNA nucleotidyl transferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trnt1"
      },
      {
        "slug": "pklr",
        "symbol": "PKLR",
        "hgnc": "HGNC:9020",
        "name": "pyruvate kinase L/R",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pklr"
      },
      {
        "slug": "rhag",
        "symbol": "RHAG",
        "hgnc": "HGNC:10006",
        "name": "Rh associated glycoprotein",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rhag"
      },
      {
        "slug": "rhce",
        "symbol": "RHCE",
        "hgnc": "HGNC:10008",
        "name": "Rh blood group CcEe antigens",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rhce"
      },
      {
        "slug": "rhd",
        "symbol": "RHD",
        "hgnc": "HGNC:10009",
        "name": "Rh blood group D antigen",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhd"
      },
      {
        "slug": "rps14",
        "symbol": "RPS14",
        "hgnc": "HGNC:10387",
        "name": "ribosomal protein S14",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps14"
      },
      {
        "slug": "uros",
        "symbol": "UROS",
        "hgnc": "HGNC:12592",
        "name": "uroporphyrinogen III synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/uros"
      },
      {
        "slug": "cask",
        "symbol": "CASK",
        "hgnc": "HGNC:1497",
        "name": "calcium/calmodulin dependent serine protein kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cask"
      },
      {
        "slug": "cdan1",
        "symbol": "CDAN1",
        "hgnc": "HGNC:1713",
        "name": "codanin 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdan1"
      },
      {
        "slug": "cdin1",
        "symbol": "CDIN1",
        "hgnc": "HGNC:26929",
        "name": "CDAN1 interacting nuclease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdin1"
      },
      {
        "slug": "g6pd",
        "symbol": "G6PD",
        "hgnc": "HGNC:4057",
        "name": "glucose-6-phosphate dehydrogenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/g6pd"
      },
      {
        "slug": "glrx5",
        "symbol": "GLRX5",
        "hgnc": "HGNC:20134",
        "name": "glutaredoxin 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glrx5"
      },
      {
        "slug": "tmprss6",
        "symbol": "TMPRSS6",
        "hgnc": "HGNC:16517",
        "name": "transmembrane serine protease 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmprss6"
      },
      {
        "slug": "umps",
        "symbol": "UMPS",
        "hgnc": "HGNC:12563",
        "name": "uridine monophosphate synthetase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/umps"
      }
    ]
  }
}