{
  "url": "https://dantelabs.com/traits/anhydramnios",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "anhydramnios",
    "id": "HP:0025700",
    "name": "Anhydramnios",
    "definition": "A complete or near-complete lack of amniotic fluid surrounding a fetus. This finding can be observed sonographically in the third trimesters if the deepest pocket of amniotic fluid is less than or equal to 2 cm.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-prenatal-development-or-birth",
        "name": "Abnormality of prenatal development or birth",
        "url": "https://dantelabs.com/traits/abnormality-of-prenatal-development-or-birth"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-amniotic-fluid",
        "name": "Abnormality of the amniotic fluid",
        "url": "https://dantelabs.com/traits/abnormality-of-the-amniotic-fluid"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "exoc3l2",
        "symbol": "EXOC3L2",
        "hgnc": "HGNC:30162",
        "name": "exocyst complex component 3 like 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/exoc3l2"
      },
      {
        "slug": "fgf20",
        "symbol": "FGF20",
        "hgnc": "HGNC:3677",
        "name": "fibroblast growth factor 20",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf20"
      },
      {
        "slug": "gfra1",
        "symbol": "GFRA1",
        "hgnc": "HGNC:4243",
        "name": "GDNF family receptor alpha 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfra1"
      },
      {
        "slug": "itga8",
        "symbol": "ITGA8",
        "hgnc": "HGNC:6144",
        "name": "integrin subunit alpha 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga8"
      },
      {
        "slug": "ubap2l",
        "symbol": "UBAP2L",
        "hgnc": "HGNC:29877",
        "name": "ubiquitin associated protein 2 like",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ubap2l"
      },
      {
        "slug": "robo1",
        "symbol": "ROBO1",
        "hgnc": "HGNC:10249",
        "name": "roundabout guidance receptor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/robo1"
      },
      {
        "slug": "tctn2",
        "symbol": "TCTN2",
        "hgnc": "HGNC:25774",
        "name": "tectonic family member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tctn2"
      }
    ]
  }
}