{
  "url": "https://dantelabs.com/traits/alpha-aminoadipic-aciduria",
  "trait": {
    "bundleId": "2026.10.18-8b139e39",
    "release": "2026-09-01",
    "slug": "alpha-aminoadipic-aciduria",
    "id": "HP:0410309",
    "name": "Alpha-aminoadipic aciduria",
    "definition": "The concentration of alpha-aminoadipic acid in the urine, normalized for urine concentration, is above the upper limit of normal.",
    "synonyms": [
      "2-aminoadipic aciduria"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "elevated-urinary-dicarboxylic-acid-level",
        "name": "Elevated urinary dicarboxylic acid level",
        "url": "https://dantelabs.com/traits/elevated-urinary-dicarboxylic-acid-level"
      },
      {
        "slug": "increased-urinary-non-proteinogenic-amino-acid-level",
        "name": "Increased urinary non-proteinogenic amino acid level",
        "url": "https://dantelabs.com/traits/increased-urinary-non-proteinogenic-amino-acid-level"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "dhtkd1",
        "symbol": "DHTKD1",
        "hgnc": "HGNC:23537",
        "name": "dehydrogenase E1 and transketolase domain containing 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dhtkd1"
      },
      {
        "slug": "nfu1",
        "symbol": "NFU1",
        "hgnc": "HGNC:16287",
        "name": "NFU1 iron-sulfur cluster scaffold",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfu1"
      },
      {
        "slug": "letm1",
        "symbol": "LETM1",
        "hgnc": "HGNC:6556",
        "name": "leucine zipper and EF-hand containing transmembrane protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/letm1"
      }
    ]
  }
}