{
  "url": "https://dantelabs.com/traits/advanced-tarsal-ossification",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "advanced-tarsal-ossification",
    "id": "HP:0008108",
    "name": "Accelerated ankle bone maturation",
    "label": "Advanced tarsal ossification",
    "definition": "Precocious (accelerated) maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.",
    "synonyms": [
      "Precociously ossified tarsal bones"
    ],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-tarsal-ossification",
        "name": "Abnormal maturation of ankle bones",
        "url": "https://dantelabs.com/traits/abnormal-tarsal-ossification"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "inppl1",
        "symbol": "INPPL1",
        "hgnc": "HGNC:6080",
        "name": "inositol polyphosphate phosphatase like 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inppl1"
      },
      {
        "slug": "slc35d1",
        "symbol": "SLC35D1",
        "hgnc": "HGNC:20800",
        "name": "solute carrier family 35 member D1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc35d1"
      },
      {
        "slug": "cant1",
        "symbol": "CANT1",
        "hgnc": "HGNC:19721",
        "name": "calcium activated nucleotidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cant1"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pth1r"
      }
    ]
  }
}