{
  "url": "https://dantelabs.com/traits/abnormal-scrotum-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-scrotum-morphology",
    "id": "HP:0000045",
    "name": "Abnormal scrotum morphology",
    "definition": "Any structural abnormality of the scrotum, i.e., the sac that contains the testes, epididymis, and the lower part of the spermatic cord.",
    "synonyms": [
      "Abnormality of the scrotum"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-male-external-genitalia-morphology",
        "name": "Abnormal male external genitalia morphology",
        "url": "https://dantelabs.com/traits/abnormal-male-external-genitalia-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "small-scrotum",
        "name": "Smaller than typical growth of scrotum",
        "genes": 72,
        "url": "https://dantelabs.com/traits/small-scrotum"
      },
      {
        "slug": "bifid-scrotum",
        "name": "Cleft of scrotum",
        "genes": 37,
        "url": "https://dantelabs.com/traits/bifid-scrotum"
      },
      {
        "slug": "shawl-scrotum",
        "name": "Scrotum surrounds penis",
        "genes": 27,
        "url": "https://dantelabs.com/traits/shawl-scrotum"
      },
      {
        "slug": "varicocele",
        "name": "Varicocele",
        "genes": 12,
        "url": "https://dantelabs.com/traits/varicocele"
      },
      {
        "slug": "abnormal-scrotal-rugation",
        "name": "Abnormal scrotal rugation",
        "genes": 4,
        "url": "https://dantelabs.com/traits/abnormal-scrotal-rugation"
      },
      {
        "slug": "scrotal-hyperpigmentation",
        "name": "Scrotal hyperpigmentation",
        "genes": 4,
        "url": "https://dantelabs.com/traits/scrotal-hyperpigmentation"
      },
      {
        "slug": "absent-scrotum",
        "name": "Absent scrotum",
        "genes": 2,
        "url": "https://dantelabs.com/traits/absent-scrotum"
      },
      {
        "slug": "prominent-scrotal-raphe",
        "name": "Prominent scrotal raphe",
        "genes": 1,
        "url": "https://dantelabs.com/traits/prominent-scrotal-raphe"
      },
      {
        "slug": "neoplasm-of-the-scrotum",
        "name": "Scrotum tumor",
        "genes": 1,
        "url": "https://dantelabs.com/traits/neoplasm-of-the-scrotum"
      }
    ],
    "genes": [
      {
        "slug": "dhx37",
        "symbol": "DHX37",
        "hgnc": "HGNC:17210",
        "name": "DEAH-box helicase 37",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhx37"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "hgnc": "HGNC:4173",
        "name": "GATA binding protein 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata4"
      },
      {
        "slug": "map3k1",
        "symbol": "MAP3K1",
        "hgnc": "HGNC:6848",
        "name": "mitogen-activated protein kinase kinase kinase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k1"
      },
      {
        "slug": "nr0b1",
        "symbol": "NR0B1",
        "hgnc": "HGNC:7960",
        "name": "nuclear receptor subfamily 0 group B member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr0b1"
      },
      {
        "slug": "nr5a1",
        "symbol": "NR5A1",
        "hgnc": "HGNC:7983",
        "name": "nuclear receptor subfamily 5 group A member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr5a1"
      },
      {
        "slug": "sox9",
        "symbol": "SOX9",
        "hgnc": "HGNC:11204",
        "name": "SRY-box transcription factor 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox9"
      },
      {
        "slug": "sry",
        "symbol": "SRY",
        "hgnc": "HGNC:11311",
        "name": "sex determining region Y",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sry"
      },
      {
        "slug": "vamp7",
        "symbol": "VAMP7",
        "hgnc": "HGNC:11486",
        "name": "vesicle associated membrane protein 7",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vamp7"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "wwox",
        "symbol": "WWOX",
        "hgnc": "HGNC:12799",
        "name": "WW domain containing oxidoreductase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wwox"
      },
      {
        "slug": "zfpm2",
        "symbol": "ZFPM2",
        "hgnc": "HGNC:16700",
        "name": "zinc finger protein, FOG family member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfpm2"
      },
      {
        "slug": "cdkn1c",
        "symbol": "CDKN1C",
        "hgnc": "HGNC:1786",
        "name": "cyclin dependent kinase inhibitor 1C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn1c"
      },
      {
        "slug": "hmga2",
        "symbol": "HMGA2",
        "hgnc": "HGNC:5009",
        "name": "high mobility group AT-hook 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmga2"
      },
      {
        "slug": "igf2",
        "symbol": "IGF2",
        "hgnc": "HGNC:5466",
        "name": "insulin like growth factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igf2"
      },
      {
        "slug": "plag1",
        "symbol": "PLAG1",
        "hgnc": "HGNC:9045",
        "name": "PLAG1 zinc finger",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plag1"
      },
      {
        "slug": "actb",
        "symbol": "ACTB",
        "hgnc": "HGNC:132",
        "name": "actin beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/actb"
      },
      {
        "slug": "mapre2",
        "symbol": "MAPRE2",
        "hgnc": "HGNC:6891",
        "name": "microtubule associated protein RP/EB family member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapre2"
      },
      {
        "slug": "tubb",
        "symbol": "TUBB",
        "hgnc": "HGNC:20778",
        "name": "tubulin beta class I",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tubb"
      }
    ]
  }
}