{
  "url": "https://dantelabs.com/traits/abnormal-respiratory-system-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-respiratory-system-morphology",
    "id": "HP:0012252",
    "name": "Abnormal respiratory system morphology",
    "definition": "A structural anomaly of the respiratory system.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-respiratory-system",
        "name": "Abnormality of the respiratory system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-respiratory-system"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-sputum",
        "name": "Abnormal sputum",
        "genes": 53,
        "url": "https://dantelabs.com/traits/abnormal-sputum"
      },
      {
        "slug": "abnormal-lung-morphology",
        "name": "Abnormality of lung structure",
        "genes": 9,
        "url": "https://dantelabs.com/traits/abnormal-lung-morphology"
      },
      {
        "slug": "abnormality-of-the-upper-respiratory-tract",
        "name": "Abnormality of the upper respiratory tract",
        "genes": 4,
        "url": "https://dantelabs.com/traits/abnormality-of-the-upper-respiratory-tract"
      },
      {
        "slug": "abnormal-tracheobronchial-morphology",
        "name": "Abnormal tracheobronchial morphology",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-tracheobronchial-morphology"
      },
      {
        "slug": "abnormal-pulmonary-thoracic-imaging-finding",
        "name": "Abnormal pulmonary thoracic imaging finding",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-pulmonary-thoracic-imaging-finding"
      },
      {
        "slug": "abnormal-respiratory-epithelium-morphology",
        "name": "Abnormal respiratory epithelium morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-respiratory-epithelium-morphology"
      }
    ],
    "genes": [
      {
        "slug": "serping1",
        "symbol": "SERPING1",
        "hgnc": "HGNC:1228",
        "name": "serpin family G member 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serping1"
      },
      {
        "slug": "col4a5",
        "symbol": "COL4A5",
        "hgnc": "HGNC:2207",
        "name": "collagen type IV alpha 5 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a5"
      },
      {
        "slug": "col4a6",
        "symbol": "COL4A6",
        "hgnc": "HGNC:2208",
        "name": "collagen type IV alpha 6 chain",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col4a6"
      },
      {
        "slug": "frem1",
        "symbol": "FREM1",
        "hgnc": "HGNC:23399",
        "name": "FRAS1 related extracellular matrix 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/frem1"
      },
      {
        "slug": "col17a1",
        "symbol": "COL17A1",
        "hgnc": "HGNC:2194",
        "name": "collagen type XVII alpha 1 chain",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/col17a1"
      },
      {
        "slug": "col7a1",
        "symbol": "COL7A1",
        "hgnc": "HGNC:2214",
        "name": "collagen type VII alpha 1 chain",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/col7a1"
      },
      {
        "slug": "mmp1",
        "symbol": "MMP1",
        "hgnc": "HGNC:7155",
        "name": "matrix metallopeptidase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mmp1"
      }
    ]
  }
}