{
  "url": "https://dantelabs.com/traits/abnormal-memory-cd8-t-cell-proportion",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-memory-cd8-t-cell-proportion",
    "id": "HP:0410380",
    "name": "Abnormal memory CD8+ T cell proportion",
    "definition": "Abnormal increase or decrease of the memory CD8+ T cell subpopulation, commonly characterized as CD45RA-, CD45RO+, or CD27-, measured as percentage of total CD8+ T cells in the blood, compared to a reference range for a given sex and age-group.",
    "synonyms": [
      "Abnormal CD8+ memory T cell proportion",
      "Abnormal proportion of CD8-positive memory T cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-cd8-t-cell-subset-proportion",
        "name": "Abnormal CD8+ T cell subset proportion",
        "url": "https://dantelabs.com/traits/abnormal-cd8-t-cell-subset-proportion"
      },
      {
        "slug": "abnormal-memory-t-cell-proportion",
        "name": "Abnormal memory T cell proportion",
        "url": "https://dantelabs.com/traits/abnormal-memory-t-cell-proportion"
      }
    ],
    "narrower": [
      {
        "slug": "increased-memory-cd8-t-cell-proportion",
        "name": "Increased memory CD8+ T cell proportion",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-memory-cd8-t-cell-proportion"
      },
      {
        "slug": "abnormal-cd8-temra-t-cell-proportion",
        "name": "Abnormal CD8+ TEMRA T cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-cd8-temra-t-cell-proportion"
      },
      {
        "slug": "abnormal-central-memory-cd8-t-cell-proportion",
        "name": "Abnormal central memory CD8+ T cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-central-memory-cd8-t-cell-proportion"
      },
      {
        "slug": "abnormal-effector-memory-cd8-t-cell-proportion",
        "name": "Abnormal effector memory CD8+ T cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-effector-memory-cd8-t-cell-proportion"
      },
      {
        "slug": "decreased-memory-cd8-t-cell-proportion",
        "name": "Decreased memory CD8+ T cell proportion",
        "genes": 0,
        "url": "https://dantelabs.com/traits/decreased-memory-cd8-t-cell-proportion"
      }
    ],
    "genes": []
  }
}