{
  "url": "https://dantelabs.com/traits/abnormal-mast-cell-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-mast-cell-morphology",
    "id": "HP:0100494",
    "name": "Abnormal mast cell morphology",
    "definition": "Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation.",
    "synonyms": [
      "Abnormality of mast cells",
      "Abnormality of mastocytes"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-granulocyte-morphology",
        "name": "Abnormal granulocyte morphology",
        "url": "https://dantelabs.com/traits/abnormal-granulocyte-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "increased-cd25-mast-cell-proportion",
        "name": "Increased CD25+ mast cell proportion",
        "genes": 6,
        "url": "https://dantelabs.com/traits/increased-cd25-mast-cell-proportion"
      },
      {
        "slug": "mastocytosis",
        "name": "Mastocytosis",
        "genes": 0,
        "url": "https://dantelabs.com/traits/mastocytosis"
      }
    ],
    "genes": [
      {
        "slug": "asxl1",
        "symbol": "ASXL1",
        "hgnc": "HGNC:18318",
        "name": "ASXL transcriptional regulator 1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/asxl1"
      },
      {
        "slug": "cbl",
        "symbol": "CBL",
        "hgnc": "HGNC:1541",
        "name": "Cbl proto-oncogene",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbl"
      },
      {
        "slug": "kit",
        "symbol": "KIT",
        "hgnc": "HGNC:6342",
        "name": "KIT proto-oncogene, receptor tyrosine kinase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kit"
      },
      {
        "slug": "runx1",
        "symbol": "RUNX1",
        "hgnc": "HGNC:10471",
        "name": "RUNX family transcription factor 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx1"
      },
      {
        "slug": "srsf2",
        "symbol": "SRSF2",
        "hgnc": "HGNC:10783",
        "name": "serine and arginine rich splicing factor 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/srsf2"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "cyp26c1",
        "symbol": "CYP26C1",
        "hgnc": "HGNC:20577",
        "name": "cytochrome P450 family 26 subfamily C member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp26c1"
      }
    ]
  }
}