{
  "url": "https://dantelabs.com/traits/abnormal-hypothalamus-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-hypothalamus-morphology",
    "id": "HP:0012286",
    "name": "Abnormal shape of hypothalamus",
    "label": "Abnormal hypothalamus morphology",
    "definition": "Any structural anomaly of the hypothalamus.",
    "synonyms": [
      "Abnormality of hypothalamus morphology",
      "Abnormality of the hypothalamus"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-diencephalon-morphology",
        "name": "Abnormal diencephalon morphology",
        "url": "https://dantelabs.com/traits/abnormal-diencephalon-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "hypothalamic-hamartoma",
        "name": "Hypothalamic hamartoma",
        "genes": 17,
        "url": "https://dantelabs.com/traits/hypothalamic-hamartoma"
      },
      {
        "slug": "dysgenesis-of-the-hypothalamus",
        "name": "Dysgenesis of the hypothalamus",
        "genes": 1,
        "url": "https://dantelabs.com/traits/dysgenesis-of-the-hypothalamus"
      },
      {
        "slug": "hypothalamic-atrophy",
        "name": "Hypothalamic atrophy",
        "genes": 1,
        "url": "https://dantelabs.com/traits/hypothalamic-atrophy"
      },
      {
        "slug": "interhypothalamic-adhesion",
        "name": "Interhypothalamic adhesion",
        "genes": 1,
        "url": "https://dantelabs.com/traits/interhypothalamic-adhesion"
      }
    ],
    "genes": [
      {
        "slug": "braf",
        "symbol": "BRAF",
        "hgnc": "HGNC:1097",
        "name": "B-Raf proto-oncogene, serine/threonine kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/braf"
      },
      {
        "slug": "ctnnb1",
        "symbol": "CTNNB1",
        "hgnc": "HGNC:2514",
        "name": "catenin beta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctnnb1"
      },
      {
        "slug": "lepr",
        "symbol": "LEPR",
        "hgnc": "HGNC:6554",
        "name": "leptin receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lepr"
      }
    ]
  }
}