{
  "url": "https://dantelabs.com/traits/abnormal-esophagus-physiology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-esophagus-physiology",
    "id": "HP:0025270",
    "name": "Abnormal esophagus physiology",
    "definition": "Any physiological abnormality of the esophagus.",
    "synonyms": [
      "Abnormality of esophagus physiology",
      "Abnormality of oesophagus physiology",
      "Functional abnormality of the esophagus",
      "Functional abnormality of the oesophagus"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      }
    ],
    "broader": [
      {
        "slug": "functional-abnormality-of-the-gastrointestinal-tract",
        "name": "Functional abnormality of the gastrointestinal tract",
        "url": "https://dantelabs.com/traits/functional-abnormality-of-the-gastrointestinal-tract"
      }
    ],
    "narrower": [
      {
        "slug": "dysphagia",
        "name": "Poor swallowing",
        "genes": 569,
        "url": "https://dantelabs.com/traits/dysphagia"
      },
      {
        "slug": "gastroesophageal-reflux",
        "name": "Acid reflux",
        "genes": 540,
        "url": "https://dantelabs.com/traits/gastroesophageal-reflux"
      },
      {
        "slug": "ineffective-esophageal-peristalsis",
        "name": "Ineffective esophageal peristalsis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/ineffective-esophageal-peristalsis"
      },
      {
        "slug": "esophageal-spasms",
        "name": "Esophageal spasms",
        "genes": 1,
        "url": "https://dantelabs.com/traits/esophageal-spasms"
      }
    ],
    "genes": [
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "hgnc": "HGNC:869",
        "name": "ATPase copper transporting alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp7a"
      },
      {
        "slug": "rhbdf2",
        "symbol": "RHBDF2",
        "hgnc": "HGNC:20788",
        "name": "rhomboid 5 homolog 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhbdf2"
      }
    ]
  }
}